2023 Q1 Form 10-K Financial Statement

#000095017023010428 Filed on March 29, 2023

View on sec.gov

Income Statement

Concept 2023 Q1 2022 Q4 2022
Revenue $174.0K $106.0K $1.180M
YoY Change -28.69% -82.09% -32.73%
Cost Of Revenue
YoY Change
Gross Profit
YoY Change
Gross Profit Margin
Selling, General & Admin $3.967M $3.770M $16.56M
YoY Change -7.12% -2.43% 7.56%
% of Gross Profit
Research & Development $12.45M $13.64M $52.04M
YoY Change 6.07% 14.87% 10.43%
% of Gross Profit
Depreciation & Amortization $576.0K $613.0K $2.500M
YoY Change -4.16% 0.33% 4.17%
% of Gross Profit
Operating Expenses $16.42M $17.41M $68.60M
YoY Change 39.86% 10.62% 9.73%
Operating Profit -$16.24M -$67.42M
YoY Change 3.03% 10.95%
Interest Expense $1.000K $610.0K $2.000K
YoY Change -98.48% 933.9% 0.0%
% of Operating Profit
Other Income/Expense, Net $621.0K -$3.000K $1.272M
YoY Change 813.24% 0.0% -31900.0%
Pretax Income -$15.62M -$16.70M -$66.15M
YoY Change -0.48% 10.65% 9.22%
Income Tax $0.00
% Of Pretax Income
Net Earnings -$15.62M -$16.70M -$66.15M
YoY Change -0.48% 10.65% 9.22%
Net Earnings / Revenue -8978.16% -15750.94% -5605.68%
Basic Earnings Per Share -$0.23 -$0.92
Diluted Earnings Per Share -$0.23 -$0.24 -$0.92
COMMON SHARES
Basic Shares Outstanding 67.73M 70.52M 71.73M
Diluted Shares Outstanding 69.07M 71.73M

Balance Sheet

Concept 2023 Q1 2022 Q4 2022
SHORT-TERM ASSETS
Cash & Short-Term Investments $57.37M $77.63M $77.63M
YoY Change -52.4% -39.63% -39.63%
Cash & Equivalents $25.54M $15.86M $15.86M
Short-Term Investments $31.83M $61.77M $61.77M
Other Short-Term Assets $4.991M $175.0K $2.153M
YoY Change 27.97% -96.29% -54.4%
Inventory
Prepaid Expenses
Receivables
Other Receivables
Total Short-Term Assets $62.36M $79.78M $79.78M
YoY Change -49.88% -40.15% -40.15%
LONG-TERM ASSETS
Property, Plant & Equipment $6.885M $7.323M $21.68M
YoY Change -71.28% -19.42% -5.65%
Goodwill
YoY Change
Intangibles
YoY Change
Long-Term Investments $0.00 $0.00
YoY Change -100.0% -100.0%
Other Assets $22.00K $7.000K $9.404M
YoY Change -99.8% 133.33% -9.66%
Total Long-Term Assets $31.08M $31.08M $31.08M
YoY Change -10.91% -24.97% -24.97%
TOTAL ASSETS
Total Short-Term Assets $62.36M $79.78M $79.78M
Total Long-Term Assets $31.08M $31.08M $31.08M
Total Assets $93.44M $110.9M $110.9M
YoY Change -41.34% -36.55% -36.55%
SHORT-TERM LIABILITIES
YoY Change
Accounts Payable $2.316M $1.785M $1.785M
YoY Change -3.86% -8.18% -8.18%
Accrued Expenses $2.421M $5.290M $9.442M
YoY Change -65.06% 20.17% 24.35%
Deferred Revenue $692.0K $882.0K
YoY Change 66.1%
Short-Term Debt $0.00 $0.00 $0.00
YoY Change
Long-Term Debt Due $14.00K $13.00K $13.00K
YoY Change 16.67% 8.33% 8.33%
Total Short-Term Liabilities $9.737M $12.12M $12.12M
YoY Change 0.76% 20.26% 20.26%
LONG-TERM LIABILITIES
Long-Term Debt $1.000K $4.000K $4.000K
YoY Change -93.33% -77.78% -77.78%
Other Long-Term Liabilities $14.99M $16.13M $16.13M
YoY Change -13.52% -7.16% -7.16%
Total Long-Term Liabilities $14.99M $16.13M $16.13M
YoY Change -13.58% -7.23% -7.23%
TOTAL LIABILITIES
Total Short-Term Liabilities $9.737M $12.12M $12.12M
Total Long-Term Liabilities $14.99M $16.13M $16.13M
Total Liabilities $24.73M $28.26M $28.26M
YoY Change -8.45% 2.86% 2.86%
SHAREHOLDERS EQUITY
Retained Earnings -$372.6M -$357.0M
YoY Change 21.53% 22.73%
Common Stock $443.9M $442.3M
YoY Change 0.94%
Preferred Stock
YoY Change
Treasury Stock (at cost) $2.518M $2.518M
YoY Change
Treasury Stock Shares $4.197M $4.197M
Shareholders Equity $68.71M $82.61M $82.61M
YoY Change
Total Liabilities & Shareholders Equity $93.44M $110.9M $110.9M
YoY Change -41.34% -36.55% -36.55%

Cashflow Statement

Concept 2023 Q1 2022 Q4 2022
OPERATING ACTIVITIES
Net Income -$15.62M -$16.70M -$66.15M
YoY Change -0.48% 10.65% 9.22%
Depreciation, Depletion And Amortization $576.0K $613.0K $2.500M
YoY Change -4.16% 0.33% 4.17%
Cash From Operating Activities -$21.51M -$12.39M -$56.89M
YoY Change 38.95% -5.11% 8.99%
INVESTING ACTIVITIES
Capital Expenditures $143.0K $43.00K $728.0K
YoY Change -70.02% -125.0% 7.22%
Acquisitions
YoY Change
Other Investing Activities $30.41M $14.90M $59.08M
YoY Change 50.3% -144.98% -212.37%
Cash From Investing Activities $30.27M $14.86M $58.35M
YoY Change 53.2% -144.62% -209.57%
FINANCING ACTIVITIES
Cash Dividend Paid
YoY Change
Common Stock Issuance & Retirement, Net $0.00
YoY Change -100.0%
Debt Paid & Issued, Net
YoY Change
Cash From Financing Activities 913.0K -2.229M -2.040M
YoY Change 591.67% 1757.5% -102.28%
NET CHANGE
Cash From Operating Activities -21.51M -12.39M -56.89M
Cash From Investing Activities 30.27M 14.86M 58.35M
Cash From Financing Activities 913.0K -2.229M -2.040M
Net Change In Cash 9.678M 239.0K -577.0K
YoY Change 119.31% -100.51% -96.41%
FREE CASH FLOW
Cash From Operating Activities -$21.51M -$12.39M -$56.89M
Capital Expenditures $143.0K $43.00K $728.0K
Free Cash Flow -$21.65M -$12.44M -$57.62M
YoY Change 35.69% -3.51% 8.96%

Facts In Submission

Frame Concept Type Concept / XBRL Key Value Unit
CY2022 us-gaap Revenue Practical Expedient Incremental Cost Of Obtaining Contract
RevenuePracticalExpedientIncrementalCostOfObtainingContract
true
CY2021Q4 us-gaap Commitments And Contingencies
CommitmentsAndContingencies
CY2022 dei Amendment Flag
AmendmentFlag
false
CY2017Q3 us-gaap Lessee Operating Lease Existence Of Option To Extend
LesseeOperatingLeaseExistenceOfOptionToExtend
true
CY2022 dei Entity Central Index Key
EntityCentralIndexKey
0001527599
CY2017Q3 us-gaap Lessee Operating Lease Existence Of Option To Terminate
LesseeOperatingLeaseExistenceOfOptionToTerminate
true
CY2022 us-gaap Lessee Operating Lease Existence Of Option To Extend
LesseeOperatingLeaseExistenceOfOptionToExtend
true
CY2022 dei Current Fiscal Year End Date
CurrentFiscalYearEndDate
--12-31
CY2021 us-gaap Income Tax Examination Likelihood Of Unfavorable Settlement
IncomeTaxExaminationLikelihoodOfUnfavorableSettlement
greater than 50%
CY2022 dei Document Fiscal Period Focus
DocumentFiscalPeriodFocus
FY
CY2021Q4 us-gaap Treasury Stock Value
TreasuryStockValue
CY2022Q4 us-gaap Commitments And Contingencies
CommitmentsAndContingencies
CY2022Q4 us-gaap Available For Sale Securities Debt Securities Noncurrent
AvailableForSaleSecuritiesDebtSecuritiesNoncurrent
CY2022 dei Document Type
DocumentType
10-K
CY2022 dei Document Annual Report
DocumentAnnualReport
true
CY2022 dei Document Period End Date
DocumentPeriodEndDate
2022-12-31
CY2022 dei Document Fiscal Year Focus
DocumentFiscalYearFocus
2022
CY2022 dei Document Transition Report
DocumentTransitionReport
false
CY2022 dei Entity File Number
EntityFileNumber
001-37566
CY2022 dei Entity Registrant Name
EntityRegistrantName
SYNLOGIC, INC.
CY2022 dei Entity Incorporation State Country Code
EntityIncorporationStateCountryCode
DE
CY2022 dei Entity Tax Identification Number
EntityTaxIdentificationNumber
26-1824804
CY2022 dei Entity Address Address Line1
EntityAddressAddressLine1
301 Binney St
CY2022 dei Entity Address Address Line2
EntityAddressAddressLine2
Suite 402
CY2022 dei Entity Address City Or Town
EntityAddressCityOrTown
Cambridge
CY2022 dei Entity Address State Or Province
EntityAddressStateOrProvince
MA
CY2022 dei Entity Address Postal Zip Code
EntityAddressPostalZipCode
02142
CY2022 dei City Area Code
CityAreaCode
617
CY2022 dei Local Phone Number
LocalPhoneNumber
401-9975
CY2022 dei Security12b Title
Security12bTitle
Common Stock, par value $0.001 per share
CY2022 dei Trading Symbol
TradingSymbol
SYBX
CY2022 dei Security Exchange Name
SecurityExchangeName
NASDAQ
CY2022 dei Entity Well Known Seasoned Issuer
EntityWellKnownSeasonedIssuer
No
CY2022 dei Entity Voluntary Filers
EntityVoluntaryFilers
No
CY2022 dei Entity Current Reporting Status
EntityCurrentReportingStatus
Yes
CY2022 dei Entity Interactive Data Current
EntityInteractiveDataCurrent
Yes
CY2022 dei Entity Filer Category
EntityFilerCategory
Non-accelerated Filer
CY2022 dei Entity Small Business
EntitySmallBusiness
true
CY2022 dei Entity Emerging Growth Company
EntityEmergingGrowthCompany
false
CY2022 dei Icfr Auditor Attestation Flag
IcfrAuditorAttestationFlag
false
CY2022 dei Entity Shell Company
EntityShellCompany
false
CY2022Q2 dei Entity Public Float
EntityPublicFloat
41500000
CY2023Q1 dei Entity Common Stock Shares Outstanding
EntityCommonStockSharesOutstanding
67728025
CY2022 dei Auditor Firm
AuditorFirmId
185
CY2022 dei Auditor Name
AuditorName
KPMG LLP
CY2022 dei Auditor Location
AuditorLocation
Boston, Massachusetts, U.S.
CY2022Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
15861000
CY2021Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
16438000
CY2022Q4 us-gaap Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
61768000
CY2021Q4 us-gaap Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
112150000
CY2022Q4 us-gaap Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
2153000
CY2021Q4 us-gaap Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
4721000
CY2022Q4 us-gaap Assets Current
AssetsCurrent
79782000
CY2021Q4 us-gaap Assets Current
AssetsCurrent
133309000
CY2021Q4 us-gaap Available For Sale Securities Debt Securities Noncurrent
AvailableForSaleSecuritiesDebtSecuritiesNoncurrent
8041000
CY2022Q4 us-gaap Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
7323000
CY2021Q4 us-gaap Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
9088000
CY2022Q4 us-gaap Operating Lease Right Of Use Asset
OperatingLeaseRightOfUseAsset
14356000
CY2021Q4 us-gaap Operating Lease Right Of Use Asset
OperatingLeaseRightOfUseAsset
13889000
CY2022Q4 us-gaap Restricted Cash Noncurrent
RestrictedCashNoncurrent
1097000
CY2021Q4 us-gaap Restricted Cash Noncurrent
RestrictedCashNoncurrent
1097000
CY2022Q4 sybx Prepaid Research And Development Noncurrent
PrepaidResearchAndDevelopmentNoncurrent
8300000
CY2021Q4 sybx Prepaid Research And Development Noncurrent
PrepaidResearchAndDevelopmentNoncurrent
9309000
CY2022Q4 us-gaap Other Assets Noncurrent
OtherAssetsNoncurrent
7000
CY2021Q4 us-gaap Other Assets Noncurrent
OtherAssetsNoncurrent
3000
CY2022Q4 us-gaap Assets
Assets
110865000
CY2021Q4 us-gaap Assets
Assets
174736000
CY2022Q4 us-gaap Accounts Payable Current
AccountsPayableCurrent
1785000
CY2021Q4 us-gaap Accounts Payable Current
AccountsPayableCurrent
1944000
CY2022Q4 us-gaap Accrued Liabilities Current
AccruedLiabilitiesCurrent
5290000
CY2021Q4 us-gaap Accrued Liabilities Current
AccruedLiabilitiesCurrent
4402000
CY2022Q4 us-gaap Contract With Customer Liability Current
ContractWithCustomerLiabilityCurrent
882000
CY2021Q4 us-gaap Contract With Customer Liability Current
ContractWithCustomerLiabilityCurrent
531000
CY2022Q4 us-gaap Operating Lease Liability Current
OperatingLeaseLiabilityCurrent
4152000
CY2021Q4 us-gaap Operating Lease Liability Current
OperatingLeaseLiabilityCurrent
3191000
CY2022Q4 us-gaap Finance Lease Liability Current
FinanceLeaseLiabilityCurrent
13000
CY2021Q4 us-gaap Finance Lease Liability Current
FinanceLeaseLiabilityCurrent
12000
CY2022Q4 us-gaap Liabilities Current
LiabilitiesCurrent
12122000
CY2021Q4 us-gaap Liabilities Current
LiabilitiesCurrent
10080000
CY2022Q4 us-gaap Operating Lease Liability Noncurrent
OperatingLeaseLiabilityNoncurrent
16129000
CY2021Q4 us-gaap Operating Lease Liability Noncurrent
OperatingLeaseLiabilityNoncurrent
17372000
CY2022Q4 us-gaap Finance Lease Liability Noncurrent
FinanceLeaseLiabilityNoncurrent
4000
CY2021Q4 us-gaap Finance Lease Liability Noncurrent
FinanceLeaseLiabilityNoncurrent
18000
CY2022Q4 us-gaap Liabilities Noncurrent
LiabilitiesNoncurrent
16133000
CY2021Q4 us-gaap Liabilities Noncurrent
LiabilitiesNoncurrent
17390000
CY2022Q4 us-gaap Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
0.001
CY2021Q4 us-gaap Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
0.001
CY2022Q4 us-gaap Common Stock Shares Authorized
CommonStockSharesAuthorized
250000000
CY2021Q4 us-gaap Common Stock Shares Authorized
CommonStockSharesAuthorized
250000000
CY2022Q4 us-gaap Common Stock Shares Issued
CommonStockSharesIssued
70933140
CY2022Q4 us-gaap Common Stock Shares Outstanding
CommonStockSharesOutstanding
66736251
CY2021Q4 us-gaap Common Stock Shares Issued
CommonStockSharesIssued
69698844
CY2021Q4 us-gaap Common Stock Shares Outstanding
CommonStockSharesOutstanding
69698844
CY2022Q4 us-gaap Common Stock Value
CommonStockValue
71000
CY2021Q4 us-gaap Common Stock Value
CommonStockValue
70000
CY2022Q4 us-gaap Additional Paid In Capital Common Stock
AdditionalPaidInCapitalCommonStock
442237000
CY2021Q4 us-gaap Additional Paid In Capital Common Stock
AdditionalPaidInCapitalCommonStock
438113000
CY2022Q4 us-gaap Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
-161000
CY2021Q4 us-gaap Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
-45000
CY2022Q4 us-gaap Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
-357019000
CY2021Q4 us-gaap Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
-290872000
CY2022Q4 us-gaap Treasury Stock Shares
TreasuryStockShares
4196889
CY2021Q4 us-gaap Treasury Stock Shares
TreasuryStockShares
0
CY2022Q4 us-gaap Treasury Stock Value
TreasuryStockValue
2518000
CY2022Q4 us-gaap Stockholders Equity
StockholdersEquity
82610000
CY2021Q4 us-gaap Stockholders Equity
StockholdersEquity
147266000
CY2022Q4 us-gaap Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
110865000
CY2021Q4 us-gaap Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
174736000
CY2022 us-gaap Revenues
Revenues
1180000
CY2021 us-gaap Revenues
Revenues
1754000
CY2022 us-gaap Research And Development Expense
ResearchAndDevelopmentExpense
52044000
CY2021 us-gaap Research And Development Expense
ResearchAndDevelopmentExpense
47127000
CY2022 us-gaap General And Administrative Expense
GeneralAndAdministrativeExpense
16555000
CY2021 us-gaap General And Administrative Expense
GeneralAndAdministrativeExpense
15392000
CY2022 us-gaap Operating Expenses
OperatingExpenses
68599000
CY2021 us-gaap Operating Expenses
OperatingExpenses
62519000
CY2022 us-gaap Operating Income Loss
OperatingIncomeLoss
-67419000
CY2021 us-gaap Operating Income Loss
OperatingIncomeLoss
-60765000
CY2022 us-gaap Investment Income Nonoperating
InvestmentIncomeNonoperating
1267000
CY2021 us-gaap Investment Income Nonoperating
InvestmentIncomeNonoperating
210000
CY2022 us-gaap Interest Expense
InterestExpense
2000
CY2021 us-gaap Interest Expense
InterestExpense
2000
CY2022 us-gaap Other Nonoperating Income Expense
OtherNonoperatingIncomeExpense
7000
CY2021 us-gaap Other Nonoperating Income Expense
OtherNonoperatingIncomeExpense
-4000
CY2022 us-gaap Nonoperating Income Expense
NonoperatingIncomeExpense
1272000
CY2021 us-gaap Nonoperating Income Expense
NonoperatingIncomeExpense
204000
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-66147000
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-60561000
CY2022 us-gaap Earnings Per Share Basic
EarningsPerShareBasic
-0.92
CY2022 us-gaap Earnings Per Share Diluted
EarningsPerShareDiluted
-0.92
CY2021 us-gaap Earnings Per Share Basic
EarningsPerShareBasic
-1.09
CY2021 us-gaap Earnings Per Share Diluted
EarningsPerShareDiluted
-1.09
CY2022 us-gaap Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
71725479
CY2022 us-gaap Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
71725479
CY2021 us-gaap Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
55329711
CY2021 us-gaap Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
55329711
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-66147000
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-60561000
CY2022 us-gaap Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
-116000
CY2021 us-gaap Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
-59000
CY2022 us-gaap Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
-66263000
CY2021 us-gaap Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
-60620000
CY2020Q4 us-gaap Stockholders Equity
StockholdersEquity
115135000
CY2021 us-gaap Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
81039000
CY2021 us-gaap Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
280000
CY2021 us-gaap Stock Issued During Period Value Employee Stock Purchase Plan
StockIssuedDuringPeriodValueEmployeeStockPurchasePlan
94000
CY2021 sybx Stock Issued During Period Value Shares Withholding
StockIssuedDuringPeriodValueSharesWithholding
73000
CY2021 us-gaap Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
3361000
CY2021 us-gaap Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
-59000
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-60561000
CY2021Q4 us-gaap Stockholders Equity
StockholdersEquity
147266000
CY2022 us-gaap Stock Repurchased During Period Value
StockRepurchasedDuringPeriodValue
2518000
CY2022 us-gaap Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
61000
CY2022 us-gaap Stock Issued During Period Value Restricted Stock Award Gross
StockIssuedDuringPeriodValueRestrictedStockAwardGross
1000
CY2022 us-gaap Stock Issued During Period Value Employee Stock Purchase Plan
StockIssuedDuringPeriodValueEmployeeStockPurchasePlan
137000
CY2022 us-gaap Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
3639000
CY2022 us-gaap Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
-116000
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-66147000
CY2022Q4 us-gaap Stockholders Equity
StockholdersEquity
82610000
CY2022 us-gaap Profit Loss
ProfitLoss
-66147000
CY2021 us-gaap Profit Loss
ProfitLoss
-60561000
CY2022 us-gaap Depreciation
Depreciation
2520000
CY2021 us-gaap Depreciation
Depreciation
2443000
CY2022 us-gaap Share Based Compensation
ShareBasedCompensation
3639000
CY2021 us-gaap Share Based Compensation
ShareBasedCompensation
3361000
CY2022 us-gaap Accretion Amortization Of Discounts And Premiums Investments
AccretionAmortizationOfDiscountsAndPremiumsInvestments
772000
CY2021 us-gaap Accretion Amortization Of Discounts And Premiums Investments
AccretionAmortizationOfDiscountsAndPremiumsInvestments
-261000
CY2022 sybx Reduction In Carrying Amount Of Operating Lease Right Of Use Asset
ReductionInCarryingAmountOfOperatingLeaseRightOfUseAsset
3149000
CY2021 sybx Reduction In Carrying Amount Of Operating Lease Right Of Use Asset
ReductionInCarryingAmountOfOperatingLeaseRightOfUseAsset
2098000
CY2022 us-gaap Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
-2568000
CY2021 us-gaap Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
-1681000
CY2022 sybx Increase Decrease In Prepaid Research And Development Net Of Current Portion
IncreaseDecreaseInPrepaidResearchAndDevelopmentNetOfCurrentPortion
1009000
CY2021 sybx Increase Decrease In Prepaid Research And Development Net Of Current Portion
IncreaseDecreaseInPrepaidResearchAndDevelopmentNetOfCurrentPortion
281000
CY2022 us-gaap Increase Decrease In Other Operating Assets
IncreaseDecreaseInOtherOperatingAssets
4000
CY2021 us-gaap Increase Decrease In Other Operating Assets
IncreaseDecreaseInOtherOperatingAssets
-1000
CY2022 us-gaap Increase Decrease In Accounts Payable And Accrued Liabilities
IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
697000
CY2021 us-gaap Increase Decrease In Accounts Payable And Accrued Liabilities
IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
538000
CY2022 us-gaap Increase Decrease In Contract With Customer Liability
IncreaseDecreaseInContractWithCustomerLiability
351000
CY2021 us-gaap Increase Decrease In Contract With Customer Liability
IncreaseDecreaseInContractWithCustomerLiability
531000
CY2022 us-gaap Increase Decrease In Operating Lease Liability
IncreaseDecreaseInOperatingLeaseLiability
-3898000
CY2021 us-gaap Increase Decrease In Operating Lease Liability
IncreaseDecreaseInOperatingLeaseLiability
-2701000
CY2022 us-gaap Increase Decrease In Other Noncurrent Liabilities
IncreaseDecreaseInOtherNoncurrentLiabilities
0
CY2021 us-gaap Increase Decrease In Other Noncurrent Liabilities
IncreaseDecreaseInOtherNoncurrentLiabilities
-131000
CY2022 us-gaap Net Cash Provided By Used In Operating Activities
NetCashProvidedByUsedInOperatingActivities
-56888000
CY2021 us-gaap Net Cash Provided By Used In Operating Activities
NetCashProvidedByUsedInOperatingActivities
-52198000
CY2022 us-gaap Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
82787000
CY2021 us-gaap Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
167866000
CY2022 us-gaap Proceeds From Sale And Maturity Of Marketable Securities
ProceedsFromSaleAndMaturityOfMarketableSecurities
141866000
CY2021 us-gaap Proceeds From Sale And Maturity Of Marketable Securities
ProceedsFromSaleAndMaturityOfMarketableSecurities
114022000
CY2022 us-gaap Proceeds From Maturities Prepayments And Calls Of Available For Sale Securities
ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities
0
CY2021 us-gaap Proceeds From Maturities Prepayments And Calls Of Available For Sale Securities
ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities
1270000
CY2022 us-gaap Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
728000
CY2021 us-gaap Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
679000
CY2022 us-gaap Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInInvestingActivities
58351000
CY2021 us-gaap Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInInvestingActivities
-53253000
CY2022 us-gaap Finance Lease Principal Payments
FinanceLeasePrincipalPayments
13000
CY2021 us-gaap Finance Lease Principal Payments
FinanceLeasePrincipalPayments
8000
CY2022 us-gaap Payments Related To Tax Withholding For Share Based Compensation
PaymentsRelatedToTaxWithholdingForShareBasedCompensation
0
CY2021 us-gaap Payments Related To Tax Withholding For Share Based Compensation
PaymentsRelatedToTaxWithholdingForShareBasedCompensation
73000
CY2022 sybx Proceeds From Employee Stock Purchases And Exercise Of Stock Options
ProceedsFromEmployeeStockPurchasesAndExerciseOfStockOptions
198000
CY2021 sybx Proceeds From Employee Stock Purchases And Exercise Of Stock Options
ProceedsFromEmployeeStockPurchasesAndExerciseOfStockOptions
374000
CY2022 us-gaap Proceeds From Issuance Of Common Stock
ProceedsFromIssuanceOfCommonStock
0
CY2021 us-gaap Proceeds From Issuance Of Common Stock
ProceedsFromIssuanceOfCommonStock
81042000
CY2022 us-gaap Payments For Repurchase Of Equity
PaymentsForRepurchaseOfEquity
2518000
CY2021 us-gaap Payments For Repurchase Of Equity
PaymentsForRepurchaseOfEquity
0
CY2022 us-gaap Net Cash Provided By Used In Financing Activities
NetCashProvidedByUsedInFinancingActivities
-2040000
CY2021 us-gaap Net Cash Provided By Used In Financing Activities
NetCashProvidedByUsedInFinancingActivities
89382000
CY2022 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
-577000
CY2021 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
-16069000
CY2021Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
17535000
CY2020Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
33604000
CY2022Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
16958000
CY2021Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
17535000
CY2022 sybx Noncash Purchase Of Property Plant And Equipment In Accounts Payable And Accrued Liabilities Adjustments
NoncashPurchaseOfPropertyPlantAndEquipmentInAccountsPayableAndAccruedLiabilitiesAdjustments
27000
CY2021 sybx Noncash Purchase Of Property Plant And Equipment In Accounts Payable And Accrued Liabilities Adjustments
NoncashPurchaseOfPropertyPlantAndEquipmentInAccountsPayableAndAccruedLiabilitiesAdjustments
40000
CY2022 sybx Assets Acquired Under Operating Lease Obligation
AssetsAcquiredUnderOperatingLeaseObligation
3616000
CY2021 sybx Assets Acquired Under Operating Lease Obligation
AssetsAcquiredUnderOperatingLeaseObligation
460000
CY2022 us-gaap Capital Lease Obligations Incurred
CapitalLeaseObligationsIncurred
0
CY2021 us-gaap Capital Lease Obligations Incurred
CapitalLeaseObligationsIncurred
36000
CY2022 sybx Issuance Costs Included In Accounts Payable And Accrued Expenses
IssuanceCostsIncludedInAccountsPayableAndAccruedExpenses
6000
CY2021 sybx Issuance Costs Included In Accounts Payable And Accrued Expenses
IssuanceCostsIncludedInAccountsPayableAndAccruedExpenses
0
CY2022 us-gaap Interest Paid Net
InterestPaidNet
2000
CY2021 us-gaap Interest Paid Net
InterestPaidNet
2000
CY2022Q4 us-gaap Cash Cash Equivalents And Short Term Investments
CashCashEquivalentsAndShortTermInvestments
77600000
CY2022Q4 us-gaap Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
-357000000.0
CY2022 us-gaap Use Of Estimates
UseOfEstimates
<p style="text-indent:0.0%;font-size:10.0pt;margin-top:18.0pt;font-family:Times New Roman;margin-bottom:0.0pt;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:bold;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;font-style:italic;min-width:fit-content;">Use of Estimates</span></p><p style="text-indent:4.533%;font-size:10.0pt;margin-top:6.0pt;font-family:Times New Roman;margin-bottom:0.0pt;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;min-width:fit-content;">The preparation of financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. On an on-going basis, the Company’s management evaluates its estimates, including those related to research and development accruals and prepaids, accrued expenses, contingencies, and investments. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results could differ from those estimates. Changes in estimates are reflected in reported results in the period in which they become known.</span></p>
CY2022 us-gaap Additional Cash And Cash Equivalent Related Text
AdditionalCashAndCashEquivalentRelatedText
three months or less
CY2022Q4 us-gaap Cash Equivalents At Carrying Value
CashEquivalentsAtCarryingValue
15900000
CY2021Q4 us-gaap Cash Equivalents At Carrying Value
CashEquivalentsAtCarryingValue
16400000
CY2022 us-gaap Concentration Risk Credit Risk
ConcentrationRiskCreditRisk
<p style="text-indent:0.0%;font-size:10.0pt;margin-top:18.0pt;font-family:Times New Roman;margin-bottom:0.0pt;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:bold;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;font-style:italic;min-width:fit-content;">Concentration of Credit Risk</span></p><p style="text-indent:4.533%;font-size:10.0pt;margin-top:6.0pt;font-family:Times New Roman;margin-bottom:0.0pt;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;min-width:fit-content;">Financial instruments that potentially subject the Company to concentrations of credit risk include amounts held as cash, cash equivalents, marketable securities and restricted cash. The Company uses high quality, accredited financial institutions to maintain its balances, and accordingly, such funds are subject to minimal credit risk. The Company has not experienced any losses in such accounts and management believes that the Company is not exposed to significant credit risk due to the financial position of the depository institutions in which those deposits are held. The Company has no financial instruments with off-balance sheet risk of loss.</span></p>
CY2022 us-gaap Revenue Practical Expedient Remaining Performance Obligation Description
RevenuePracticalExpedientRemainingPerformanceObligationDescription
The Company recognizes as an asset the incremental costs of obtaining a contract with a customer if the costs are expected to be recovered. As a practical expedient, the Company recognizes the incremental costs of obtaining a contract as an expense when incurred if the amortization period of the asset that we otherwise would have recognized is one year or less. To date, the Company has not incurred any incremental costs of obtaining a contract with a customer
CY2021Q4 us-gaap Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
4721000
CY2022Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
15861000
CY2021Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
16438000
CY2022Q4 us-gaap Restricted Cash
RestrictedCash
1097000
CY2021Q4 us-gaap Restricted Cash
RestrictedCash
1097000
CY2022Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
16958000
CY2021Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
17535000
CY2022 sybx Fair Value Asset Liability Transfers Between Level1 Level2 And Level3 Amount
FairValueAssetLiabilityTransfersBetweenLevel1Level2AndLevel3Amount
0
CY2021 sybx Fair Value Asset Liability Transfers Between Level1 Level2 And Level3 Amount
FairValueAssetLiabilityTransfersBetweenLevel1Level2AndLevel3Amount
0
CY2022 us-gaap Property Plant And Equipment Impairment
PropertyPlantAndEquipmentImpairment
<p style="text-indent:0.0%;font-size:10.0pt;margin-top:8.0pt;font-family:Times New Roman;margin-bottom:0.0pt;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:bold;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;font-style:italic;min-width:fit-content;">Impairment of Long‑Lived Assets</span></p><p style="text-indent:4.533%;font-size:10.0pt;margin-top:6.0pt;font-family:Times New Roman;margin-bottom:0.0pt;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;min-width:fit-content;">Long‑lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the asset may not be recoverable. When such events occur, the Company compares the carrying amounts of the assets to their undiscounted expected future cash flows. If this comparison indicates that there is impairment, the amount of impairment is calculated as the difference between the carrying value and fair value of the asset. To date, </span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;min-width:fit-content;">no</span><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:&quot;Times New Roman&quot;, serif;min-width:fit-content;"> such impairments have been recognized.</span></p>
CY2022 us-gaap Tangible Asset Impairment Charges
TangibleAssetImpairmentCharges
0
CY2022 us-gaap Lessee Operating Lease Option To Extend
LesseeOperatingLeaseOptionToExtend
options to extend the lease when it is reasonably certain that option will be exercised
CY2022Q4 us-gaap Lessee Operating Lease Term Of Contract
LesseeOperatingLeaseTermOfContract
P12M
CY2022 us-gaap Income Tax Examination Likelihood Of Unfavorable Settlement
IncomeTaxExaminationLikelihoodOfUnfavorableSettlement
greater than 50%
CY2022 us-gaap Number Of Operating Segments
NumberOfOperatingSegments
1
CY2022Q4 sybx Prepaid Research And Development Current
PrepaidResearchAndDevelopmentCurrent
320000
CY2021Q4 sybx Prepaid Research And Development Current
PrepaidResearchAndDevelopmentCurrent
2721000
CY2022Q4 us-gaap Other Prepaid Expense Current
OtherPrepaidExpenseCurrent
771000
CY2021Q4 us-gaap Other Prepaid Expense Current
OtherPrepaidExpenseCurrent
710000
CY2022Q4 us-gaap Other Assets Current
OtherAssetsCurrent
175000
CY2021Q4 us-gaap Other Assets Current
OtherAssetsCurrent
311000
CY2022Q4 us-gaap Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
2153000
CY2022Q4 us-gaap Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
61929000
CY2022Q4 us-gaap Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
8000
CY2022Q4 us-gaap Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
169000
CY2022Q4 us-gaap Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
61768000
CY2021Q4 us-gaap Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
120236000
CY2021Q4 us-gaap Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
8000
CY2021Q4 us-gaap Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
53000
CY2021Q4 us-gaap Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
120191000
CY2022Q4 us-gaap Debt Securities Available For Sale Unrealized Loss Position
DebtSecuritiesAvailableForSaleUnrealizedLossPosition
36600000
CY2021Q4 us-gaap Debt Securities Available For Sale Unrealized Loss Position
DebtSecuritiesAvailableForSaleUnrealizedLossPosition
72200000
CY2022Q4 sybx Other Than Temporary Impairment Losses Investments Number Debt Securities Available For Sale
OtherThanTemporaryImpairmentLossesInvestmentsNumberDebtSecuritiesAvailableForSale
0
CY2022Q4 us-gaap Prepaid Insurance
PrepaidInsurance
887000
CY2021Q4 us-gaap Prepaid Insurance
PrepaidInsurance
979000
CY2022Q4 us-gaap Property Plant And Equipment Gross
PropertyPlantAndEquipmentGross
20463000
CY2021Q4 us-gaap Property Plant And Equipment Gross
PropertyPlantAndEquipmentGross
19714000
CY2022Q4 us-gaap Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
13140000
CY2021Q4 us-gaap Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
10626000
CY2022Q4 us-gaap Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
7323000
CY2021Q4 us-gaap Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
9088000
CY2022 us-gaap Depreciation
Depreciation
2500000
CY2021 us-gaap Depreciation
Depreciation
2400000
CY2022Q4 us-gaap Employee Related Liabilities Current
EmployeeRelatedLiabilitiesCurrent
3401000
CY2021Q4 us-gaap Employee Related Liabilities Current
EmployeeRelatedLiabilitiesCurrent
3495000
CY2022Q4 us-gaap Accrued Professional Fees Current
AccruedProfessionalFeesCurrent
152000
CY2021Q4 us-gaap Accrued Professional Fees Current
AccruedProfessionalFeesCurrent
298000
CY2022Q4 sybx Accrued Research And Development Current
AccruedResearchAndDevelopmentCurrent
1624000
CY2021Q4 sybx Accrued Research And Development Current
AccruedResearchAndDevelopmentCurrent
336000
CY2022Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
113000
CY2021Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
273000
CY2022Q4 us-gaap Accrued Liabilities Current
AccruedLiabilitiesCurrent
5290000
CY2021Q4 us-gaap Accrued Liabilities Current
AccruedLiabilitiesCurrent
4402000
CY2022 sybx Number Of Votes Entitled To Each Share Of Common Stock
NumberOfVotesEntitledToEachShareOfCommonStock
1
us-gaap Dividends Common Stock Cash
DividendsCommonStockCash
0
CY2021 us-gaap Income Tax Expense Benefit
IncomeTaxExpenseBenefit
0
CY2022Q4 us-gaap Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
81803000
CY2021Q4 us-gaap Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
76802000
CY2022Q4 us-gaap Common Stock Capital Shares Reserved For Future Issuance
CommonStockCapitalSharesReservedForFutureIssuance
5928776
CY2022Q4 sybx Share Based Compensation By Share Based Arrangement Award Options Available For Aggregate Intrinsic Value
ShareBasedCompensationByShareBasedArrangementAwardOptionsAvailableForAggregateIntrinsicValue
185500
CY2021Q4 sybx Share Based Compensation By Share Based Arrangement Award Options Available For Aggregate Intrinsic Value
ShareBasedCompensationByShareBasedArrangementAwardOptionsAvailableForAggregateIntrinsicValue
1210026
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
1.16
CY2021 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
2.42
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue
3200000
CY2021 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue
2800000
CY2022Q4 us-gaap Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
4900000
CY2022 us-gaap Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1
P2Y7M6D
CY2022 us-gaap Share Based Compensation
ShareBasedCompensation
3600000
CY2021 us-gaap Share Based Compensation
ShareBasedCompensation
3400000
CY2022 us-gaap Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
3639000
CY2021 us-gaap Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
3361000
CY2022Q4 us-gaap Deferred Tax Assets Tax Credit Carryforwards
DeferredTaxAssetsTaxCreditCarryforwards
9118000
CY2021Q4 us-gaap Deferred Tax Assets Tax Credit Carryforwards
DeferredTaxAssetsTaxCreditCarryforwards
7248000
CY2022Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities
DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities
127000
CY2021Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities
DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities
181000
CY2022Q4 us-gaap Deferred Tax Assets Property Plant And Equipment
DeferredTaxAssetsPropertyPlantAndEquipment
888000
CY2022 us-gaap Share Based Compensation
ShareBasedCompensation
3639000
CY2021 us-gaap Share Based Compensation
ShareBasedCompensation
3361000
CY2022 sybx Anticipated Completion Of Research And Development Projects Period
AnticipatedCompletionOfResearchAndDevelopmentProjectsPeriod
P2Y
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-66147000
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-60561000
CY2022 us-gaap Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
71725479
CY2022 us-gaap Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
71725479
CY2021 us-gaap Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
55329711
CY2021 us-gaap Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
55329711
CY2022 us-gaap Earnings Per Share Basic
EarningsPerShareBasic
-0.92
CY2022 us-gaap Earnings Per Share Diluted
EarningsPerShareDiluted
-0.92
CY2021 us-gaap Earnings Per Share Basic
EarningsPerShareBasic
-1.09
CY2021 us-gaap Earnings Per Share Diluted
EarningsPerShareDiluted
-1.09
CY2022 us-gaap Income Tax Expense Benefit
IncomeTaxExpenseBenefit
0
CY2021Q4 us-gaap Deferred Tax Assets Property Plant And Equipment
DeferredTaxAssetsPropertyPlantAndEquipment
591000
CY2022Q4 sybx Deferred Tax Assets Lease Liabilities
DeferredTaxAssetsLeaseLiabilities
5541000
CY2021Q4 sybx Deferred Tax Assets Lease Liabilities
DeferredTaxAssetsLeaseLiabilities
5618000
CY2022Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost
2516000
CY2021Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost
2396000
CY2022Q4 us-gaap Deferred Tax Assets Goodwill And Intangible Assets
DeferredTaxAssetsGoodwillAndIntangibleAssets
1165000
CY2021Q4 us-gaap Deferred Tax Assets Goodwill And Intangible Assets
DeferredTaxAssetsGoodwillAndIntangibleAssets
1197000
CY2022Q4 sybx Deferred Tax Assets Amortizable Research Expenditures
DeferredTaxAssetsAmortizableResearchExpenditures
12000000
CY2021Q4 sybx Deferred Tax Assets Amortizable Research Expenditures
DeferredTaxAssetsAmortizableResearchExpenditures
0
CY2022Q4 us-gaap Deferred Tax Assets Other
DeferredTaxAssetsOther
363000
CY2021Q4 us-gaap Deferred Tax Assets Other
DeferredTaxAssetsOther
238000
CY2022Q4 us-gaap Deferred Tax Assets Gross
DeferredTaxAssetsGross
113521000
CY2021Q4 us-gaap Deferred Tax Assets Gross
DeferredTaxAssetsGross
94271000
CY2022Q4 sybx Deferred Tax Liabilities Right Of Use Assets
DeferredTaxLiabilitiesRightOfUseAssets
3922000
CY2021Q4 sybx Deferred Tax Liabilities Right Of Use Assets
DeferredTaxLiabilitiesRightOfUseAssets
3794000
CY2022Q4 us-gaap Deferred Income Tax Liabilities
DeferredIncomeTaxLiabilities
3922000
CY2021Q4 us-gaap Deferred Income Tax Liabilities
DeferredIncomeTaxLiabilities
3794000
CY2022Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
109599000
CY2021Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
90477000
CY2022Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
109600000
CY2021Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
90500000
CY2022 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.21
CY2021 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.21
CY2022 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
0.06
CY2021 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
0.06
CY2022 us-gaap Effective Income Tax Rate Reconciliation Nondeductible Expense Other
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther
-0.01
CY2021 us-gaap Effective Income Tax Rate Reconciliation Nondeductible Expense Other
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther
0
CY2022 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
0.03
CY2021 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
0.02
CY2022 us-gaap Effective Income Tax Rate Reconciliation Other Adjustments
EffectiveIncomeTaxRateReconciliationOtherAdjustments
0
CY2021 us-gaap Effective Income Tax Rate Reconciliation Other Adjustments
EffectiveIncomeTaxRateReconciliationOtherAdjustments
0
CY2022 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
-0.29
CY2021 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
-0.29
CY2021Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
90477000
CY2020Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
72791000
CY2022 us-gaap Valuation Allowance Deferred Tax Asset Change In Amount
ValuationAllowanceDeferredTaxAssetChangeInAmount
-19122000
CY2021 us-gaap Valuation Allowance Deferred Tax Asset Change In Amount
ValuationAllowanceDeferredTaxAssetChangeInAmount
-17686000
CY2022Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
109599000
CY2021Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
90477000
CY2022Q4 us-gaap Operating Loss Carryforwards
OperatingLossCarryforwards
302500000
CY2022Q3 sybx Corporate Minimum Tax Effect Percentage
CorporateMinimumTaxEffectPercentage
0.15
CY2022Q4 sybx Excise Tax Percentage
ExciseTaxPercentage
0.01
CY2022Q4 us-gaap Unrecognized Tax Benefits
UnrecognizedTaxBenefits
0
CY2022Q4 us-gaap Income Tax Examination Penalties And Interest Accrued
IncomeTaxExaminationPenaltiesAndInterestAccrued
0
CY2021Q4 us-gaap Income Tax Examination Penalties And Interest Accrued
IncomeTaxExaminationPenaltiesAndInterestAccrued
0
CY2022 us-gaap Income Tax Examination Description
IncomeTaxExaminationDescription
In the normal course of business, the Company is subject to examination by federal and state jurisdictions, where applicable. There are currently no pending tax examinations. Tax years from 2019 to the present are open to examination under the statute.
CY2022Q4 sybx Repurchase Of Common Stock
RepurchaseOfCommonStock
4196889
CY2022Q4 sybx Aggregate Purchase
AggregatePurchase
2500000
CY2022Q4 sybx Aggregate Purchase Per Share
AggregatePurchasePerShare
0.60
CY2017Q3 sybx Rentable Space Under Lease Agreement
RentableSpaceUnderLeaseAgreement
41346
CY2017Q3 sybx Operating Leases Rent Expense Annual Rental Payments
OperatingLeasesRentExpenseAnnualRentalPayments
3400000
CY2017Q3 us-gaap Lessee Operating Lease Term Of Contract
LesseeOperatingLeaseTermOfContract
P10Y
CY2017Q3 sybx Tenant Improvement Investment Obligation
TenantImprovementInvestmentObligation
2900000
CY2017Q3 us-gaap Line Of Credit Facility Maximum Borrowing Capacity
LineOfCreditFacilityMaximumBorrowingCapacity
1000000.0
CY2017Q3 us-gaap Lessee Operating Lease Renewal Term
LesseeOperatingLeaseRenewalTerm
P5Y
CY2018 sybx Agreement Expiration Date
AgreementExpirationDate
2022-12-31
CY2022 us-gaap Operating Lease Payments
OperatingLeasePayments
5500000
CY2021 us-gaap Operating Lease Payments
OperatingLeasePayments
4400000
CY2022 us-gaap Operating Lease Cost
OperatingLeaseCost
4812000
CY2021 us-gaap Operating Lease Cost
OperatingLeaseCost
3824000
CY2022 us-gaap Variable Lease Cost
VariableLeaseCost
1409000
CY2021 us-gaap Variable Lease Cost
VariableLeaseCost
1500000
CY2022 sybx Operating And Variable Lease Cost
OperatingAndVariableLeaseCost
6221000
CY2021 sybx Operating And Variable Lease Cost
OperatingAndVariableLeaseCost
5324000
CY2022Q4 us-gaap Operating Lease Weighted Average Discount Rate Percent
OperatingLeaseWeightedAverageDiscountRatePercent
0.083
CY2021Q4 us-gaap Operating Lease Weighted Average Discount Rate Percent
OperatingLeaseWeightedAverageDiscountRatePercent
0.080
CY2022Q4 us-gaap Operating Lease Weighted Average Remaining Lease Term1
OperatingLeaseWeightedAverageRemainingLeaseTerm1
P5Y1M6D
CY2021Q4 us-gaap Operating Lease Weighted Average Remaining Lease Term1
OperatingLeaseWeightedAverageRemainingLeaseTerm1
P6Y3M18D
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due Next Twelve Months
LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
5626000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Two
LesseeOperatingLeaseLiabilityPaymentsDueYearTwo
4749000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Three
LesseeOperatingLeaseLiabilityPaymentsDueYearThree
3792000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Four
LesseeOperatingLeaseLiabilityPaymentsDueYearFour
3905000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Five
LesseeOperatingLeaseLiabilityPaymentsDueYearFive
4022000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due After Year Five
LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive
2667000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due
LesseeOperatingLeaseLiabilityPaymentsDue
24761000
CY2022Q4 us-gaap Lessee Operating Lease Liability Undiscounted Excess Amount
LesseeOperatingLeaseLiabilityUndiscountedExcessAmount
4480000
CY2022Q4 us-gaap Operating Lease Liability
OperatingLeaseLiability
20281000
CY2022Q4 us-gaap Operating Lease Liability Current
OperatingLeaseLiabilityCurrent
4152000
CY2022Q4 us-gaap Operating Lease Liability Noncurrent
OperatingLeaseLiabilityNoncurrent
16129000
CY2020 us-gaap Defined Contribution Plan Employer Matching Contribution Percent Of Match
DefinedContributionPlanEmployerMatchingContributionPercentOfMatch
0.50
CY2020 us-gaap Defined Contribution Plan Maximum Annual Contributions Per Employee Percent
DefinedContributionPlanMaximumAnnualContributionsPerEmployeePercent
0.04
CY2020 us-gaap Defined Contribution Plan Employer Matching Contribution Percent
DefinedContributionPlanEmployerMatchingContributionPercent
0.02
CY2021 us-gaap Defined Contribution Plan Employer Matching Contribution Percent Of Match
DefinedContributionPlanEmployerMatchingContributionPercentOfMatch
0.50
CY2021 us-gaap Defined Contribution Plan Maximum Annual Contributions Per Employee Percent
DefinedContributionPlanMaximumAnnualContributionsPerEmployeePercent
0.06
CY2021 us-gaap Defined Contribution Plan Employer Matching Contribution Percent
DefinedContributionPlanEmployerMatchingContributionPercent
0.03
CY2022 us-gaap Defined Contribution Plan Employer Discretionary Contribution Amount
DefinedContributionPlanEmployerDiscretionaryContributionAmount
500000
CY2021 us-gaap Defined Contribution Plan Employer Discretionary Contribution Amount
DefinedContributionPlanEmployerDiscretionaryContributionAmount
300000

Files In Submission

Name View Source Status
0000950170-23-010428-index-headers.html Edgar Link pending
0000950170-23-010428-index.html Edgar Link pending
0000950170-23-010428.txt Edgar Link pending
0000950170-23-010428-xbrl.zip Edgar Link pending
Financial_Report.xlsx Edgar Link pending
img119790510_0.jpg Edgar Link pending
img119790510_1.jpg Edgar Link pending
img119790510_10.jpg Edgar Link pending
img119790510_2.jpg Edgar Link pending
img119790510_3.jpg Edgar Link pending
img119790510_4.jpg Edgar Link pending
img119790510_5.jpg Edgar Link pending
img119790510_6.jpg Edgar Link pending
img119790510_7.jpg Edgar Link pending
img119790510_8.jpg Edgar Link pending
img119790510_9.jpg Edgar Link pending
img51355790_0.jpg Edgar Link pending
img51355790_1.jpg Edgar Link pending
MetaLinks.json Edgar Link pending
R1.htm Edgar Link pending
R10.htm Edgar Link pending
R11.htm Edgar Link pending
R12.htm Edgar Link pending
R13.htm Edgar Link pending
R14.htm Edgar Link pending
R15.htm Edgar Link pending
R16.htm Edgar Link pending
R17.htm Edgar Link pending
R18.htm Edgar Link pending
R19.htm Edgar Link pending
R2.htm Edgar Link pending
R20.htm Edgar Link pending
R21.htm Edgar Link pending
FilingSummary.xml Edgar Link unprocessable
R22.htm Edgar Link pending
R23.htm Edgar Link pending
R24.htm Edgar Link pending
R25.htm Edgar Link pending
R26.htm Edgar Link pending
R27.htm Edgar Link pending
R28.htm Edgar Link pending
R29.htm Edgar Link pending
R3.htm Edgar Link pending
R30.htm Edgar Link pending
R31.htm Edgar Link pending
R32.htm Edgar Link pending
R33.htm Edgar Link pending
R34.htm Edgar Link pending
R35.htm Edgar Link pending
R36.htm Edgar Link pending
R37.htm Edgar Link pending
R38.htm Edgar Link pending
R39.htm Edgar Link pending
R4.htm Edgar Link pending
R40.htm Edgar Link pending
R41.htm Edgar Link pending
R42.htm Edgar Link pending
R43.htm Edgar Link pending
R44.htm Edgar Link pending
R45.htm Edgar Link pending
R46.htm Edgar Link pending
R47.htm Edgar Link pending
R48.htm Edgar Link pending
R49.htm Edgar Link pending
R5.htm Edgar Link pending
R50.htm Edgar Link pending
R51.htm Edgar Link pending
R52.htm Edgar Link pending
R53.htm Edgar Link pending
R54.htm Edgar Link pending
R55.htm Edgar Link pending
R56.htm Edgar Link pending
R57.htm Edgar Link pending
R58.htm Edgar Link pending
R59.htm Edgar Link pending
R6.htm Edgar Link pending
R60.htm Edgar Link pending
R61.htm Edgar Link pending
R62.htm Edgar Link pending
R63.htm Edgar Link pending
R64.htm Edgar Link pending
R65.htm Edgar Link pending
R66.htm Edgar Link pending
R67.htm Edgar Link pending
R68.htm Edgar Link pending
R69.htm Edgar Link pending
R7.htm Edgar Link pending
R8.htm Edgar Link pending
R9.htm Edgar Link pending
report.css Edgar Link pending
Show.js Edgar Link pending
sybx-20221231.htm Edgar Link pending
sybx-20221231.xsd Edgar Link pending
sybx-ex10_32.htm Edgar Link pending
sybx-ex21_1.htm Edgar Link pending
sybx-ex23_1.htm Edgar Link pending
sybx-ex31_1.htm Edgar Link pending
sybx-ex31_2.htm Edgar Link pending
sybx-ex32_1.htm Edgar Link pending
sybx-ex32_2.htm Edgar Link pending
sybx-20221231_cal.xml Edgar Link unprocessable
sybx-20221231_lab.xml Edgar Link unprocessable
sybx-20221231_def.xml Edgar Link unprocessable
sybx-20221231_pre.xml Edgar Link unprocessable
sybx-20221231_htm.xml Edgar Link completed