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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net (Loss) income | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation expense | |||||
| Stock‑based compensation expense | |||||
| Net amortization of premium (accretion of discount) on marketable securities | |||||
| Changes in operating assets and liabilities: | |||||
| Collaboration receivable | |||||
| Prepaid expenses and other current assets | |||||
| Right-of-use assets, operating leases | |||||
| Other non-current assets | |||||
| Accounts payable | |||||
| Accrued expenses and other current liabilities | |||||
| Income taxes payable | |||||
| Deferred revenue | |||||
| Operating lease liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property and equipment | |||||
| Purchases of marketable securities | |||||
| Maturities of marketable securities | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from issuance of common stock in connection with the Vertex Agreement | |||||
| Proceeds from issuance of common stock and pre-funded warrants in registered direct offering, net of issuance costs paid | |||||
| Registered Direct Offering | |||||
| Vertex Agreement | |||||
| Proceeds from exercise of stock options | |||||
| Proceeds from issuance of common stock under the employee stock purchase plan | |||||
| Net cash provided by financing activities | |||||
| Net (decrease) increase in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of year | |||||
| Cash, cash equivalents and restricted cash at end of year | |||||
| Supplemental cash flow disclosures: | |||||
| Purchases of property and equipment included in accounts payable and accrued expenses | |||||
| Right-of-use assets obtained in exchange for operating lease liabilities | |||||
| Right-of-use assets surrendered as part of lease modification | |||||
| Recognition of right-of-use assets upon adoption of ASC 842 | |||||
| Transfer of deposits for equipment from operating to investing cash flows | |||||
| Vesting of options early exercised subject to repurchase | |||||
| Cash paid for income taxes | |||||
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