Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.
Reported portfolio value by quarter (47 quarters reported)
$208M in Q4 2014 → $8.17B now. Hover for any quarter.
As reported for the quarter ended June 30, 2026. Activity is the change in share count since the prior quarter's filing.
| Holding | % of portfolio | Activity | Shares | Value |
|---|---|---|---|---|
| SS State Str SPDR S&P 500 ETF T Put | 29.2% | Added 52% | 3,200,000 | $2.39B |
| IT Ishares Tr Put | 21.3% | Added 66% | 5,800,000 | $1.74B |
| Madrigal Pharmaceuticals Inc | 1.9% | Added 8.9% | 288,000 | $155M |
| Cytokinetics Inc Call | 1.6% | Trimmed 10% | 1,530,000 | $130M |
| Supernus Pharmaceuticals | 1.5% | Added 40% | 2,646,201 | $123M |
| Agios Pharmaceuticals Inc Call | 1.3% | Trimmed 12% | 2,810,000 | $104M |
| Cytokinetics Inc | 1.3% | Added 57% | 1,201,342 | $102M |
| Incyte Corp | 1.2% | Added 37% | 900,005 | $102M |
| Neurocrine Biosciences Inc | 1.1% | Trimmed 26% | 535,838 | $90.3M |
| Travere Therapeutics Inc | 1.1% | Trimmed 68% | 1,572,539 | $89.3M |
| Agios Pharmaceuticals Inc | 1.1% | Trimmed 12% | 2,400,000 | $89.1M |
| Ptc Therapeutics Inc | 1.1% | Trimmed 48% | 1,071,395 | $87.4M |
| Unitedhealth Group Inc | 0.9% | Added 24% | 183,000 | $76.1M |
| Freshpet Inc | 0.9% | Added 15% | 1,260,702 | $74.5M |
| Dyne Therapeutics Inc | 0.8% | Trimmed 2.8% | 3,087,226 | $68.6M |
| Amazon Com Inc | 0.8% | Added 8.6% | 284,562 | $67.8M |
| Immunovant Inc | 0.8% | Trimmed 51% | 1,736,000 | $66.9M |
| Rigel Pharmaceuticals Inc | 0.8% | Added 31% | 1,672,000 | $65.4M |
| Thermo Fisher Scientific Inc | 0.8% | Added 34% | 122,480 | $61.4M |
| Ironwood Pharmaceuticals Inc | 0.7% | Trimmed 7.3% | 13,932,000 | $58.7M |
| HB Harmony Biosciences Hldgs In | 0.7% | Trimmed 3.7% | 1,564,000 | $56.9M |
| Regeneron Pharmaceuticals | 0.7% | Added 149% | 89,809 | $56M |
| Ptc Therapeutics Inc Call | 0.7% | Added 69% | 660,000 | $53.8M |
| Nektar Therapeutics | 0.6% | Added 25% | 724,000 | $50.5M |
| Mineralys Therapeutics Inc | 0.6% | Added 48% | 1,736,000 | $46.8M |
| Immunovant Inc Call | 0.6% | Trimmed 37% | 1,200,000 | $46.2M |
| Sanofi Sa | 0.6% | Added 255% | 1,064,000 | $45.4M |
| IH Immunocore Hldgs PLC | 0.6% | Added 20% | 1,428,000 | $45.3M |
| Alphabet Inc | 0.6% | Added 6.7% | 126,494 | $45.2M |
| Solid Biosciences Inc | 0.5% | Added 34% | 4,278,000 | $42.7M |
| Mongodb Inc | 0.5% | Added 17% | 125,172 | $42M |
| Kura Oncology Inc | 0.5% | Trimmed 1.6% | 3,678,000 | $40.3M |
| Dentsply Sirona Inc | 0.5% | Added 22% | 3,672,000 | $39M |
| Uber Technologies Inc | 0.4% | Trimmed 4.0% | 497,908 | $35.9M |
| Axogen Inc | 0.4% | Trimmed 17% | 775,000 | $35.8M |
| Disc Medicine Inc | 0.4% | Trimmed 14% | 460,000 | $33.6M |
| Gitlab Inc | 0.4% | Added 4.4% | 1,074,141 | $32.8M |
| Five9 Inc | 0.4% | Trimmed 3.5% | 1,536,000 | $32.7M |
| Hubspot Inc | 0.4% | Added 38% | 178,047 | $32.5M |
| Align Technology Inc | 0.4% | Added 14% | 180,286 | $30.4M |
| Microsoft Corp | 0.4% | Added 65% | 80,581 | $30.1M |
| OM Orthofix Med Inc | 0.4% | Added 21% | 3,264,000 | $29.8M |
| Humana Inc | 0.4% | Trimmed 49% | 72,527 | $28.8M |
| Angiodynamics Inc | 0.3% | Added 18% | 2,198,000 | $28.6M |
| Travere Therapeutics Inc Call | 0.3% | New | 500,000 | $28.4M |
| Waters Corp | 0.3% | New | 75,004 | $28.1M |
| Mineralys Therapeutics Inc Call | 0.3% | New | 1,040,000 | $28.1M |
| Sentinelone Inc Call | 0.3% | Trimmed 3.0% | 1,600,000 | $27.2M |
| Verastem Inc | 0.3% | Added 53% | 7,024,000 | $26.8M |
| 4M 4d Molecular Therapeutics In | 0.3% | Unchanged | 2,000,000 | $26.6M |
| Intellia Therapeutics Inc | 0.3% | Added 346% | 1,500,000 | $25.4M |
| Wynn Resorts Ltd | 0.3% | Added 50% | 261,065 | $25.3M |
| TM Treace Med Concepts Inc | 0.3% | Unchanged | 6,364,000 | $25.3M |
| Autolus Therapeutics Ltd | 0.3% | Trimmed 5.1% | 15,000,000 | $24M |
| Arvinas Inc | 0.3% | Added 41% | 2,796,000 | $23.2M |
| Macrogenics Inc | 0.3% | Trimmed 17% | 5,006,752 | $23.1M |
| Alto Neuroscience Inc | 0.3% | Trimmed 5.3% | 864,000 | $22.8M |
| Toast Inc | 0.3% | Added 40% | 810,830 | $22.6M |
| Uipath Inc | 0.3% | Added 56% | 2,000,000 | $21.7M |
| GS Grifols S A | 0.3% | Trimmed 1.7% | 2,936,000 | $20.8M |
Showing top 60 of 333 positions.
What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.
quarter ended June 30, 2026 · filed August 14, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| SS State Str SPDR S&P 500 ETF T | Added | +1,100,000 | +$821M | 29.2% |
| IT Ishares Tr | Added | +2,300,000 | +$691M | 21.3% |
| Travere Therapeutics Inc | Trimmed | −3,324,878 | −$189M | 1.1% |
| Ptc Therapeutics Inc | Trimmed | −1,003,054 | −$81.8M | 1.1% |
| Immunovant Inc | Trimmed | −1,828,916 | −$70.5M | 0.8% |
| Datadog Inc | Trimmed | −170,885 | −$44.5M | 0.1% |
| Cytokinetics Inc | Added | +436,804 | +$37.2M | 1.3% |
| Supernus Pharmaceuticals | Added | +750,854 | +$34.9M | 1.5% |
| Regeneron Pharmaceuticals | Added | +53,683 | +$33.5M | 0.7% |
| Sanofi Sa | Added | +764,000 | +$32.6M | 0.6% |
Showing the 10 largest of 413 changes.
quarter ended March 31, 2026 · filed May 15, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| IT Ishares Tr | Trimmed | −4,600,000 | −$1.14B | 15.4% |
| SS State Str SPDR S&P 500 ETF T | Trimmed | −900,000 | −$585M | 24.3% |
| Kenvue Inc | Trimmed | −3,962,592 | −$68.3M | — |
| Immunovant Inc | Trimmed | −2,182,239 | −$54.2M | 1.6% |
| Dentsply Sirona Inc | Trimmed | −4,298,000 | −$49.9M | 0.6% |
| Ptc Therapeutics Inc | Trimmed | −727,420 | −$49.6M | 2.5% |
| Argenx Se | Exited | −58,000 | −$48.8M | — |
| GH Ge Healthcare Technologies I | Trimmed | −673,711 | −$48M | 0.1% |
| Starbucks Corp | Exited | −549,805 | −$46.3M | — |
| Supernus Pharmaceuticals | Trimmed | −868,653 | −$44.9M | 1.7% |
Showing the 10 largest of 452 changes.
quarter ended December 31, 2025 · filed February 17, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| SS SPDR S&P 500 ETF Tr | Added | +500,000 | +$341M | 24.3% |
| IT Ishares Tr | Added | +1,100,000 | +$271M | 23.7% |
| Travere Therapeutics Inc | Trimmed | −2,960,109 | −$113M | 1.7% |
| Madrigal Pharmaceuticals Inc | Added | +145,723 | +$84.9M | 1.8% |
| Kenvue Inc | New | +3,992,196 | +$68.9M | 0.8% |
| Agios Pharmaceuticals Inc | Added | +2,272,000 | +$61.8M | 1.0% |
| MJ Mdgl Jan6 400.0c | Exited | −130,000 | −$59.6M | — |
| Agios Pharmaceuticals Inc | Added | +2,100,000 | +$57.2M | 1.0% |
| ES Exact Sciences Ord | Exited | −1,030,465 | −$56.4M | — |
| Gsk PLC | New | +1,000,000 | +$49M | 0.6% |
Showing the 10 largest of 493 changes.
quarter ended September 30, 2025 · filed November 17, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| SP Supernus Pharmaceuticals Ord | Trimmed | −1,976,000 | −$94.4M | 2.0% |
| PT Ptc Therapeutics Ord | Trimmed | −1,458,192 | −$89.5M | 3.0% |
| DS Dentsply Sirona Ord | Added | +5,234,587 | +$66.4M | 1.1% |
| TT Travere Therapeutics Ord | Trimmed | −2,152,000 | −$51.4M | 2.4% |
| GA Grifols ADR Rep One Non Vtg Cl B Ord | Trimmed | −5,062,000 | −$50.4M | 0.3% |
| Staar Surgical Co | Exited | −2,812,000 | −$47.2M | — |
| NN Novo Nordisk ADR Repsg 1 Ord | New | +736,000 | +$40.8M | 0.6% |
| FO Freshpet Ord | Added | +669,399 | +$36.9M | 1.0% |
| MO Mcdonald's Ord | Trimmed | −119,810 | −$36.4M | 0.1% |
| AF Agio Feb6 40.0 C | New | +900,000 | +$36.1M | 0.5% |
Showing the 10 largest of 376 changes.
quarter ended June 30, 2025 · filed August 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| IT Ishares Tr | Added | +300,000 | +$64.7M | 26.1% |
| Exact Sciences Corp | Trimmed | −1,030,413 | −$54.8M | 0.7% |
| SB Spectrum Brands Hldgs Inc Ne | Exited | −691,000 | −$49.4M | — |
| Simply Good Foods Co | Exited | −1,351,593 | −$46.6M | — |
| Cytokinetics Inc | Trimmed | −1,360,000 | −$44.9M | 0.8% |
| Sensient Technologies Corp | Trimmed | −446,022 | −$43.9M | 0.2% |
| Dominos Pizza Inc | Exited | −90,068 | −$41.4M | — |
| Neurocrine Biosciences Inc | Trimmed | −324,166 | −$40.7M | 1.5% |
| Dentsply Sirona Inc | Trimmed | −2,498,735 | −$39.7M | 0.1% |
| Madrigal Pharmaceuticals Inc | Trimmed | −130,000 | −$39.3M | 0.9% |
Showing the 10 largest of 262 changes.
quarter ended March 31, 2025 · filed May 15, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Madrigal Pharmaceuticals Inc | New | +300,000 | +$99.4M | 1.5% |
| Vertex Pharmaceuticals Inc | Trimmed | −174,016 | −$84.4M | 0.4% |
| Cytokinetics Inc | Added | +2,090,000 | +$84M | 1.6% |
| IM Inari Med Inc | Exited | −1,565,577 | −$79.9M | — |
| Gsk PLC | Trimmed | −2,000,000 | −$77.5M | 0.2% |
| AB Anheuser Busch Inbev Sa/nv | Exited | −1,359,000 | −$68M | — |
| Humana Inc | Trimmed | −255,977 | −$67.7M | 0.2% |
| Freshpet Inc | New | +716,960 | +$59.6M | 0.9% |
| Icon PLC | Trimmed | −318,060 | −$55.7M | 0.3% |
| Regeneron Pharmaceuticals | Added | +86,028 | +$54.6M | 1.1% |
Showing the 10 largest of 275 changes.
quarter ended December 31, 2024 · filed February 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| IT Ishares Tr | Added | +1,600,000 | +$354M | 20.5% |
| SS SPDR S&P 500 ETF Tr | Added | +500,000 | +$293M | 20.0% |
| Neurocrine Biosciences Inc | Added | +710,619 | +$97M | 1.7% |
| Exact Sciences Corp | New | +1,617,000 | +$90.9M | 1.2% |
| Icon PLC | New | +418,112 | +$87.7M | 1.2% |
| Cytokinetics Inc | Trimmed | −1,590,000 | −$74.8M | 0.4% |
| Vertex Pharmaceuticals Inc | Added | +177,887 | +$71.6M | 1.2% |
| Gsk PLC | Added | +1,854,000 | +$62.7M | 1.1% |
| Alkermes PLC | Exited | −1,448,654 | −$40.5M | — |
| Ptc Therapeutics Inc | Trimmed | −856,898 | −$38.7M | 3.9% |
Showing the 10 largest of 294 changes.
quarter ended September 30, 2024 · filed November 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| SS SPDR S&P 500 ETF Tr | Trimmed | −1,900,000 | −$1.09B | 18.4% |
| IT Ishares Tr | Trimmed | −4,400,000 | −$972M | 18.4% |
| Neurocrine Biosciences Inc | Trimmed | −797,107 | −$91.8M | 0.3% |
| Cytokinetics Inc | Added | +1,200,000 | +$63.4M | 1.9% |
| Exact Sciences Corp | Exited | −1,400,086 | −$59.2M | — |
| Sanofi | Trimmed | −920,000 | −$53M | 0.5% |
| Keurig Dr Pepper Inc | Exited | −1,486,063 | −$49.6M | — |
| Gsk PLC | Trimmed | −976,000 | −$39.9M | 0.3% |
| CS Campbell Soup Co | Trimmed | −732,441 | −$35.8M | 0.3% |
| Alkermes PLC | Trimmed | −1,250,525 | −$35M | 0.6% |
Showing the 10 largest of 306 changes.
Loading...
