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Super Investors New Leaf Venture Partners, L.L.C.
NL

New Leaf Venture Partners, L.L.C.

Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.

Portfolio value
$43M
Positions
7
Quarter ended
September 30, 2025
Filed
November 14, 2025

Reported portfolio value by quarter (44 quarters reported)

$550M $43M
Q4 14 Q1 17 Q2 19 Q3 21 Q4 23 Q3 25

$206M in Q4 2014 → $43M now. Hover for any quarter.

Holdings

As reported for the quarter ended September 30, 2025. Activity is the change in share count since the prior quarter's filing.

Holding % of portfolio Activity Shares Value
E Ewtx 38.8% Unchanged 1,030,161 $16.7M
A Arvn 31.4% Unchanged 1,585,721 $13.5M
C Crnx 13.6% Unchanged 141,000 $5.87M
C Cogt 8.4% Unchanged 250,765 $3.6M
R Rlyb 3.8% Unchanged 3,301,603 $1.65M
A Alec 2.3% Unchanged 339,569 $1.01M
P Pasg 1.6% Trimmed 97% 87,426 $702K

Timeline of changes

What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.

Q3 2025

quarter ended September 30, 2025 · filed November 14, 2025

Company Action Shares changed Value of change % of portfolio
P Pasg Trimmed −2,410,496 −$19.4M 1.6%
Iterum Therapeutics PLC Exited −345,020 −$343K —

Q2 2025

quarter ended June 30, 2025 · filed August 13, 2025

Company Action Shares changed Value of change % of portfolio
Rocket Pharmaceuticals Inc Exited −150,706 −$1.01M —

Q1 2025

quarter ended March 31, 2025 · filed May 13, 2025

No position changes this quarter.

Q4 2024

quarter ended December 31, 2024 · filed February 13, 2025

Company Action Shares changed Value of change % of portfolio
Edgewise Therapeutics Inc Trimmed −523,500 −$14M 36.8%
Arvinas Inc Added +151,000 +$2.89M 40.6%
X4 Pharmaceuticals Inc Exited −335,000 −$224K —

Q3 2024

quarter ended September 30, 2024 · filed November 13, 2024

Company Action Shares changed Value of change % of portfolio
Arvinas Inc Added +145,200 +$3.58M 36.3%
Iterum Therapeutics PLC Added +247,934 +$270K 0.4%

Q2 2024

quarter ended June 30, 2024 · filed August 14, 2024

Company Action Shares changed Value of change % of portfolio
Deciphera Pharmaceuticals Inc Exited −576,975 −$9.08M —
Rocket Pharmaceuticals Inc Added +32,464 +$699K 3.9%
Iterum Therapeutics PLC Added +2 +$2 0.1%

Q1 2024

quarter ended March 31, 2024 · filed May 14, 2024

Company Action Shares changed Value of change % of portfolio
Harpoon Therapeutics Inc Exited −1,859,168 −$21.1M —

Q4 2023

quarter ended December 31, 2023 · filed February 14, 2024

Company Action Shares changed Value of change % of portfolio
Harpoon Therapeutics Inc Added +1,543,500 +$17.5M 17.0%
Deciphera Pharmaceuticals Inc Trimmed −632,596 −$10.2M 7.5%
Cogent Biosciences Inc. Trimmed −250,765 −$1.47M 1.2%

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