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Sierra Oncology, Inc.

No Longer Reporting

The company has not filed an annual or quarterly report since its Q1 FY2022 10-Q, filed May 6, 2022. Its latest SEC filing is a SC 13G/A from Feb 14, 2023.

The sections below describe the company as of the FY2021 annual report.

What Did They Do?

Develops targeted drug candidates for rare cancers, with momelotinib in development for people with myelofibrosis.

How Did They Make Money?

The company receives upfront license fees under a collaboration agreement with Carna Biosciences.

FY2020 revenue

Who Were Their Customers?

The company planned to market momelotinib directly to hematologists and oncologists in North America, while exploring partners for commercialization in certain global regions.

Did Revenues Turn Into Profits?

No. It lost $80.9M in FY2020.

Operating income, FY2020
−21647% of revenue
Net income, FY2020
−26967% of revenue
Free cash flow, FY2020
−17460% of revenue

How Were They Changing?

Since the FY2021 annual report
Latest quarter: Q1 FY2022, the three months to Mar 31, 2022
Net income
▲ +40% (Loss)
vs −$19.9M in Q1 FY2021
  • Jul 1, 2022 GSK completed its acquisition of Sierra Oncology Sierra became a wholly owned subsidiary of GSK.
  • Apr 13, 2022 Sierra agreed to be acquired by GSK The agreement would make Sierra a wholly owned subsidiary of GSK.

A new licensed drug candidate The newer report adds a licensed cancer drug candidate to the portfolio; the earlier report discussed momelotinib and a checkpoint kinase inhibitor.

Momelotinib advances toward filing The earlier report anticipated another study to support momelotinib registration; the latest says its pivotal trial produced positive results and that Sierra planned an FDA application.

Who Did They Compete With?

Competes with Incyte, Novartis, Celgene, Bristol Meyers Squibb, CTI Biopharma, Morphosys, AbbVie, Kartos, Geron, Zelgen Biopharmaceuticals, Plexxicon, Zenith Epigenetics, Esperas Pharma, and Acrivon Therapeutics

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