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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Share-based compensation | |||||
| Non-cash royalty revenue | |||||
| Non-cash interest expense | |||||
| Loss (gain) on sale or disposal of assets, net | |||||
| Gain from deconsolidation of MiNK Therapeutics, Inc. | |||||
| Loss on impairment of assets | |||||
| Gain on forgiveness of liability | |||||
| Gain on lease terminations | |||||
| Unrealized loss on long-term investments | |||||
| Fair value adjustments | |||||
| Other, net | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Prepaid expenses | |||||
| Accounts payable | |||||
| Deferred revenue | |||||
| Accrued liabilities and other current liabilities | |||||
| Other operating assets and liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Proceeds from sale of property, plant and equipment | |||||
| Purchases of property, plant and equipment | |||||
| Purchases of available-for-sale securities | |||||
| Proceeds from sale of available-for-sale securities | |||||
| Purchase of long-term investment | |||||
| Proceeds from sale of long-term investment | |||||
| Net cash provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Net proceeds from sale of equity | |||||
| Net proceeds from sale of subsidiary shares in private placement | |||||
| Proceeds from employee stock purchases and option exercises | |||||
| Purchase of treasury shares to satisfy tax withholdings | |||||
| Purchase of subsidiary shares | |||||
| Proceeds from Ligand Purchase Agreement, net of expenses | |||||
| Proceeds from the issuance of long-term debt, net | |||||
| Impact to cash resulting from deconsolidation certain subsidiaries | |||||
| Payment of long-term debt | |||||
| Payment of finance lease obligations | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash | |||||
| Net decrease in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash, beginning of period | |||||
| Cash, cash equivalents and restricted cash, end of period | |||||
| Supplemental cash flow information: | |||||
| Cash paid for interest | |||||
| Supplemental disclosures - non-cash activities: | |||||
| Issuance of stock options for payment of certain employee bonuses | |||||
| Issuance of common stock | |||||
| Employee Bonus | |||||
| Payment for Services | |||||
| Long-Term Debt | |||||
| Issuance of subsidiary stock options for payment of certain employee bonuses | |||||
| Issuance of subsidiary shares for employee bonus | |||||
| Insurance financing agreements | |||||
| Lease right-of-use assets obtained in exchange for new operating lease liabilities | |||||
| Lease right-of-use assets obtained in exchange for new finance lease liabilities | |||||
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