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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating Activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation | |||||
| Amortization of intangible asset | |||||
| Interest expense related to sale of future royalties (non-cash) | |||||
| Bad debt expense | |||||
| Change in fair value of warrant liability | |||||
| Non-cash royalty revenue related to sale of future royalties | |||||
| Collaboration revenue in connection with the termination of the Otsuka Agreement (non-cash) | |||||
| Non-cash research and development expense | |||||
| Non-cash interest expense | |||||
| Non-cash operating lease expense | |||||
| Non-cash loss on extinguishment of debt | |||||
| Provision of inventories | |||||
| Non-cash write-off on termination of lease | |||||
| Charge for purchase of IPR&D asset | |||||
| Write-down of inventory | |||||
| Change in firm purchase commitments | |||||
| Change in excess inventory purchase commitments | |||||
| Stock-based compensation expense | |||||
| Deferred income taxes | |||||
| Gain on the sale of property and equipment | |||||
| Change in fair value of embedded debt derivative | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Inventory | |||||
| Prepaid expenses and other current assets | |||||
| Other long-term assets | |||||
| Accounts payable | |||||
| Accrued expense and other current liabilities | |||||
| Operating lease liabilities | |||||
| Deferred revenue | |||||
| Other long-term liabilities | |||||
| Net cash provided by (used in) operating activities | |||||
| Investing Activities: | |||||
| Purchase of equipment | |||||
| Proceeds from the sale of property and equipment | |||||
| Purchase of IPR&D asset, including transaction costs | |||||
| Net cash used in investing activities | |||||
| Financing Activities: | |||||
| Proceeds from refund liability to customer | |||||
| Proceeds from the issuance of debt | |||||
| Payments of issuance costs related to BlackRock Credit Agreement | |||||
| Proceeds from the issuance of common stock, net of issuance costs | |||||
| Proceeds from the sale of stock under employee stock purchase plan | |||||
| Proceeds from the exercise of common stock options | |||||
| Principal payments on debt | |||||
| Repayment of WCF liability | |||||
| Repayment of liability related to settlement royalties | |||||
| Repayment of term debt | |||||
| Net cash provided by (used in) financing activities | |||||
| Increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of the period | |||||
| Cash, cash equivalents and restricted cash at end of the period | |||||
| Supplemental cash flow information | |||||
| Issuance of warrants in connection with BlackRock Credit Agreement | |||||
| Cashless exercise of warrants in connection with BlackRock Credit Agreement | |||||
| Purchase of IPR&D asset included in accrued expenses and other current liabilities | |||||
| Cash paid for interest | |||||
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