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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Stock-based compensation | |||||
| Amortization of premiums and accretion of discounts on marketable securities | |||||
| Amortization of right-of-use assets | |||||
| Amortization of debt discount and debt issuance costs | |||||
| Impairment loss of right-of-use assets and leasehold improvements | |||||
| Loss from disposal of fixed assets | |||||
| Changes in operating assets and liabilities: | |||||
| Receivable from collaboration partner | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued liabilities and accrued clinical supply costs | |||||
| Payable to collaboration partner | |||||
| Deferred revenue | |||||
| Refund liability to collaboration partner | |||||
| Lease liabilities | |||||
| Other long-term liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchase of property and equipment | |||||
| Purchase of marketable securities | |||||
| Maturities of marketable securities | |||||
| Sale of marketable securities | |||||
| Net cash provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from the exercise of options to purchase common stock | |||||
| Proceeds from issuance of stock from employee stock purchase plan | |||||
| Proceeds from issuance of common stock, net of issuance costs | |||||
| Proceeds from issuance of common stock upon public offering, net of issuance costs | |||||
| Proceeds from debt financing, net of discount and issuance costs | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash, cash equivalents, and restricted cash | |||||
| Cash, cash equivalents, and restricted cash at beginning of period | |||||
| Cash, cash equivalents, and restricted cash at end of period | |||||
| Non-cash investing and financing activities: | |||||
| Property and equipment purchases included in accounts payable and accrued liabilities | |||||
| Interest paid | |||||
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