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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net income (loss) | |||||
| Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: | |||||
| Depreciation and amortization | |||||
| Amortization and interest accretion related to operating leases | |||||
| Non-cash interest expense on liabilities related to the sale of future royalties and development funding | |||||
| Stock-based compensation expense | |||||
| Realized and unrealized loss on marketable equity securities | |||||
| Loss related to convertible debt | |||||
| Change in fair value of development derivative liability | |||||
| Deferred income taxes | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable, net | |||||
| Inventory | |||||
| Prepaid expenses and other assets | |||||
| Accounts payable, accrued expenses and other liabilities | |||||
| Operating lease liability | |||||
| Deferred revenue | |||||
| Net cash provided by (used in) operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property, plant and equipment | |||||
| Purchases of marketable securities | |||||
| Sales and maturities of marketable securities | |||||
| Proceeds from maturity of restricted investments | |||||
| Purchases of restricted investments | |||||
| Other investing activities | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from issuance of 0.00% Convertible Senior Notes due 2028, net | |||||
| Purchases of capped calls related to convertible debt | |||||
| Proceeds from the sale of future royalties | |||||
| Purchases of capped calls related to 0.00% Convertible Senior Notes due 2028 | |||||
| Repayment of 1.00% Convertible Senior Notes due 2027 | |||||
| Payment of issuance costs for revolving credit agreement | |||||
| Proceeds from exercise of stock options and other types of equity, net | |||||
| Proceeds from liabilities related to the sale of future royalties and development funding | |||||
| Repayment of liabilities related to the sale of future royalties and development funding | |||||
| (Repayment of) proceeds from development derivative liability, net | |||||
| Repayment of term loan facility | |||||
| Other financing activities | |||||
| Net cash (used in) provided by financing activities | |||||
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash, beginning of period | |||||
| Cash, cash equivalents and restricted cash, end of period | |||||
| Supplemental disclosure of cash flows: | |||||
| Cash paid for interest | |||||
| Cash paid for income taxes | |||||
| Operating lease right-of-use assets obtained in exchange for new operating lease liabilities | |||||
| Supplemental disclosure of noncash investing activities: | |||||
| Capital expenditures included in accounts payable and accrued expenses | |||||
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