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About Denali Therapeutics Inc.
Denali Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of a portfolio of product candidates for neurodegenerative diseases. The company is headquartered in South San Francisco, California and currently employs 390 full-time employees. The company went IPO on 2017-12-08. The firm is focused on developing a portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases and lysosomal storage disease. The firm has a portfolio of both small molecule and biotherapeutic medicines, comprising seven product candidates in clinical development across seven indications as well as preclinical therapeutic candidates. Its three late-stage development programs include tividenofusp alfa (DNL310) for mucopolysaccharidosis II (MPS II); BIIB122/DNL151 (LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (eIF2B activator) for amyotrophic lateral sclerosis (ALS). SAR443820/DNL788 (RIPK1 inhibitor) is being evaluated in a Phase II study for multiple sclerosis (MS). In addition, it has a Phase I/II study of TAK-594/DNL593 for frontotemporal dementia-granulin (FTD-GRN) and a Phase I/II study of DNL126 for MPS IIIA (Sanfilippo syndrome).
Industry: Biological Products, (No Diagnostic Substances) Peers: ACADIA PHARMACEUTICALS INC AMICUS THERAPEUTICS, INC. ARROWHEAD PHARMACEUTICALS, INC. Beam Therapeutics Inc. Blueprint Medicines Corp ChemoCentryx, Inc. Mirati Therapeutics, Inc. PTC THERAPEUTICS, INC. Ultragenyx Pharmaceutical Inc.
