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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Stock-based compensation expense | |||||
| In process research and development expenses | |||||
| Amortization of operating lease right-of-use assets | |||||
| Amortization of long-term debt discount and issuance costs | |||||
| Amortization of premium on investments, net of accretion of discounts | |||||
| Net realized gain on investments | |||||
| Loss on disposal of property and equipment | |||||
| Changes in operating assets and liabilities: | |||||
| Receivable from contracts with collaborators | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Operating lease liabilities | |||||
| Accounts payable | |||||
| Accrued expenses | |||||
| Accrued research and development expenses | |||||
| Accrued compensation and benefits | |||||
| Contract liabilities | |||||
| Accrued interest expense | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities | |||||
| Research and development asset acquisitions, net of cash acquired | |||||
| Purchase of marketable securities | |||||
| Maturities of marketable securities | |||||
| Sales of marketable securities | |||||
| Purchase of property and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities | |||||
| Proceeds from issuance of common stock under Employee Stock Purchase Plan | |||||
| Proceeds from the exercise of stock options | |||||
| Proceeds from the exercise of warrants | |||||
| Proceeds from issuance of equity option pursuant to stock purchase agreement | |||||
| Principal repayments of long-term debt | |||||
| Net cash provided by (used in) financing activities | |||||
| Effect of exchange rate changes on cash and cash equivalents | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents, at the beginning of the period | |||||
| Cash and cash equivalents, at the end of the period | |||||
| Supplemental disclosure of cash flow information: | |||||
| Cash paid for interest | |||||
| Supplemental disclosure of noncash investing and financing activities: | |||||
| Right-of-use assets obtained in exchange for lease liabilities | |||||
| Derecognition ROU lease assets obtained in exchange for operating lease liabilities | |||||
| Change in unrealized gain (loss) on marketable securities, net | |||||
| Purchases of property and equipment included in accounts payable and accrued expenses and other current liabilities | |||||
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