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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation | |||||
| Depreciation and amortization | |||||
| Non-cash interest expense | |||||
| Stock-based compensation expense | |||||
| Non-cash operating lease expense | |||||
| Accretion/amortization of premium/discount of available-for-sale securities | |||||
| Amortization of marketable securities | |||||
| Amortization of right of use-assets | |||||
| Gain on early extinguishment of lease liability | |||||
| Loss on disposal of property and equipment | |||||
| Impairment of right of use asset | |||||
| Impairment of assets held for sale | |||||
| Non-cash research and development expenses for the common stock issuable pursuant to Hutchmed Agreement | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other current assets | |||||
| Deposits and other assets | |||||
| Other non-current assets | |||||
| Accounts payable | |||||
| Accrued expenses and other current liabilities | |||||
| Deferred revenue | |||||
| Operating lease liabilities | |||||
| Lease liability | |||||
| Other long-term liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property and equipment | |||||
| Cash divested in Non-OX40 divestiture | |||||
| Proceeds from disposal of property and equipment | |||||
| Purchases of marketable securities | |||||
| Maturities and sales of marketable securities | |||||
| Amounts loaned under note receivable | |||||
| Net cash (used in) provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Cash and cash equivalents acquired in connection with the acquisition of Pionyr, net of issuance costs paid | |||||
| Cash consideration paid in connection with the acquisition of Pionyr | |||||
| Proceeds from issuance of common stock for underwritten registered offering, net of offering costs | |||||
| Repurchase of common stock | |||||
| Proceeds from term loan | |||||
| Proceeds from exercise of stock options | |||||
| Issuance costs in connection with reverse recapitalization | |||||
| Cash acquired in connection with reverse recapitalization | |||||
| Proceeds from common stock issued in PIPE Financing, net of issuance costs | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Effects of exchange rates on cash and cash equivalents | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents, beginning of year | |||||
| Cash and cash equivalents, end of year | |||||
| Cash and cash equivalents | |||||
| Restricted cash included in deposits and other assets | |||||
| Restricted cash included in other assets | |||||
| Supplemental disclosure of cash flow information: | |||||
| Right-of-use asset recognized upon assumption of San Francisco, CA lease from Pionyr | |||||
| Cash paid for income taxes, net | |||||
| Supplemental disclosure of non-cash investing and financing information: | |||||
| Accretion of redeemable convertible preferred shares | |||||
| Deferred offering costs in accrued expenses and other current liabilities | |||||
| Exchange of preferred shares into common stock upon closing of reverse recapitalization | |||||
| Forgiveness of term loan upon closing of reverse recapitalization | |||||
| Reverse recapitalization issuance costs in accrued expenses | |||||
| Issuance of promissory note in connection with divesture | |||||
| Net assets derecognized in connection with Non-OX40 Divestiture | |||||
| Unrealized gain on marketable securities | |||||
| Right-of-use assets acquired by assuming operating lease liability | |||||
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