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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation | |||||
| Amortization of intangible assets | |||||
| Amortization of operating lease right-of-use assets | |||||
| Change in fair value of common stock warrant liabilities | |||||
| Impairment of goodwill | |||||
| Impairment of intangible assets | |||||
| Deferred taxes | |||||
| Non-cash stock-based compensation | |||||
| Non-cash interest on senior convertible notes | |||||
| Amortization of discounts on investments | |||||
| Loss on sales of short-term investments | |||||
| Gain on remeasurement of investment in Geneos | |||||
| Net gain on disposal of fixed assets | |||||
| (Gain) loss on equity investment in affiliated entity | |||||
| Share of net loss in Geneos | |||||
| Net unrealized gain on available-for-sale equity securities | |||||
| Unrealized transaction (gain) loss on foreign-currency denominated debt | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable, including from affiliated entities | |||||
| Prepaid expenses and other current assets, including from affiliated entity | |||||
| Other assets | |||||
| Accounts payable and accrued expenses, including due to affiliated entity | |||||
| Accrued clinical trial expenses | |||||
| Deferred revenue, including from affiliated entity | |||||
| Operating lease right-of-use assets and liabilities, net | |||||
| Grant funding liability, including from affiliated entity | |||||
| Other liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of investments | |||||
| Proceeds from sale of investments | |||||
| Proceeds from maturity of investments | |||||
| Purchases of capital assets | |||||
| Proceeds from sale of capital assets | |||||
| Investment in Geneos | |||||
| Net cash provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Repayment of convertible senior notes | |||||
| Proceeds from issuance of pre-funded warrants, net of issuance costs | |||||
| Proceeds from issuance of warrants, net of issuance costs | |||||
| Pre-Funded Warrants | |||||
| Warrants to purchase common stock | |||||
| Total proceeds from issuance of warrants, net of issuance costs | |||||
| Proceeds from issuance of common stock, net of issuance costs | |||||
| Proceeds from warrant exercises | |||||
| Proceeds from stock option exercises | |||||
| Taxes paid related to net share settlement of equity awards | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash and cash equivalents | |||||
| (Decrease) Increase in cash and cash equivalents | |||||
| Cash and cash equivalents, beginning of period | |||||
| Cash and cash equivalents, end of period | |||||
| Supplemental disclosure: | |||||
| Amounts accrued for purchases of fixed assets | |||||
| Interest paid | |||||
| Change in prepaid expenses and other current assets related to fixed assets | |||||
| Issuance of common stock as part of litigation settlement | |||||
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