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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation | |||||
| Amortization of intangible assets | |||||
| Stock-based compensation expense | |||||
| Loss on extinguishment of debt | |||||
| Accretion of debt discount | |||||
| Amortization of debt issuance costs | |||||
| Paid-in-kind interest capitalized | |||||
| Royalty financing non-cash interest expense | |||||
| Accretion of discount on marketable securities, net | |||||
| Finance lease amortization expense | |||||
| Non-cash operating lease expense | |||||
| Change in fair value of deferred and contingent consideration liabilities | |||||
| Change in fair value of interest rate swap | |||||
| Vertuis/Adrestia acquisition | |||||
| Vertuis Bio, Inc. | |||||
| Adrestia Therapeutics Ltd | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Inventory | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable and accrued liabilities | |||||
| Other liabilities | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Purchase of fixed assets | |||||
| Payment of AZ milestone | |||||
| Purchase of marketable securities | |||||
| Cash acquired in asset acquisition | |||||
| Cash paid for Business Acquisition, net | |||||
| Maturities of marketable securities | |||||
| Net cash used in investing activities | |||||
| Financing activities | |||||
| Proceeds from exercise of stock options and ESPP | |||||
| Proceeds from issuance of common stock, net | |||||
| Payment on extinguishment of 1.75% convertible senior notes due 2025 | |||||
| Proceeds from issuance of Term Loan | |||||
| Proceeds from issuance Royalty Financing Agreement | |||||
| Payments of principal of 0.75% convertible senior notes due 2028 | |||||
| Proceeds from issuance of 0.75% convertible senior notes due 2028 | |||||
| Payment of debt issuance costs | |||||
| Payments of finance lease principal | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rates on cash and cash equivalents | |||||
| Net (decrease) increase in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash and cash equivalents at end of period | |||||
| Supplemental disclosures of cash flow information: | |||||
| Cash paid for interest | |||||
| Cash paid for income taxes | |||||
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