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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net Income Loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation expense | |||||
| Depreciation and amortization expense | |||||
| Non-cash operating lease cost | |||||
| Net (accretion) amortization of (discounts) premiums on investments | |||||
| Gain on sale of VOWST Business, net of transaction costs | |||||
| Amortization of debt issuance costs | |||||
| Loss associated with extinguishment of debt | |||||
| (Gain)/loss on disposal of fixed assets | |||||
| Impairment of long-lived assets | |||||
| Change in fair value of warrant liabilities | |||||
| Collaboration (profit) loss sharing - related party (1) | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable due from SPN - related party | |||||
| Prepaid expenses and other current and non-current assets | |||||
| Accounts receivable | |||||
| Collaboration receivable - related party | |||||
| Inventories | |||||
| Deferred income - related party | |||||
| Deferred revenue - related party | |||||
| Accounts payable | |||||
| Accrued liabilities due to SPN - related party | |||||
| Operating lease liabilities | |||||
| Accrued expenses and other current and long-term liabilities | |||||
| Net cash provided by (used in) operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property and equipment | |||||
| Proceeds from sales of property and equipment | |||||
| Purchases of investments | |||||
| Sales and maturities of investments | |||||
| Sales of restricted investments | |||||
| Proceeds from sale of VOWST Business | |||||
| Net cash (used in) provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from at the market equity offering, net of issuance costs | |||||
| Proceeds from exercise of stock options | |||||
| Proceeds from Securities Purchase Agreement - related party | |||||
| Issuance of common stock under ESPP | |||||
| Proceeds from issuance of debt, net of issuance costs | |||||
| Repayment of notes payable | |||||
| Net cash provided by (used in) financing activities | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of year | |||||
| Cash, cash equivalents and restricted cash at end of year | |||||
| Supplemental disclosure of cash flow information: | |||||
| Cash paid for interest | |||||
| Supplemental disclosure of non-cash investing and financing activities: | |||||
| Property and equipment purchases included in accounts payable and accrued expenses | |||||
| Lease liability arising from obtaining right-of-use assets | |||||
| Prepaid rent reclassified to right-of-use assets | |||||
| Recognition of warrant liabilities | |||||
| Warrants issued related to Oaktree Term Loan and recorded as debt discount | |||||
| Warrants issued related to prior credit facility with Oaktree and recorded as debt discount | |||||
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