| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| Capital Fund IV Cooperatief U.A. Forbion | 10,656,172 | 0 | - |
| James N Topper | 3,028,524 | +14,755 | ∞ |
| Life Sciences Associates, LP BCIP | 1,632,653 | 0 | - |
| Michael H. Davidson | 617,851 | +102,239 | 1.14 |
| Johannes Jacob Pieter Kastelein | 170,711 | -87,534 | 0.79 |
| Mayur Ian Somaiya | 98,166 | +104,060 | 5.85 |
| Louise Frederika Kooij | 56,965 | +106,056 | 1.3 |
| Michael F III Marino | 55,000 | 0 | - |
| Douglas F Kling | 44,000 | -246 | 1.0 |
| WILLIAM A JR JONES | 43,000 | 0 | - |
| Juliette Berangere Audet | 30,000 | 0 | - |
| Adele M. Gulfo | 14,260 | +3,400 | ∞ |
| LOUIS G LANGE | 10,806 | -24,340 | 0.66 |
| John W Smither | 10,360 | +3,400 | ∞ |
| der Kamp Hilde Johanna van | 10,360 | +3,400 | ∞ |
| Mark C. McKenna | 10,360 | +3,400 | ∞ |
| William Lewis | 10,360 | +3,400 | ∞ |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| LOUIS G LANGE | Mar 12 |
Open Market Sale (S)
Market Sale
|
10,806 | -44,173 | $30.41 | -$1,343,300 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| LOUIS G LANGE | Mar 10 |
In/At-money Exercise (X)
Derivative Exercise
|
54,979 | +44,619 | $11.50 | +$513,118 |
| Johannes Jacob Pieter Kastelein | Mar 09 |
Option Exercise/Conversion (M)
Compensation/Award
|
170,711 | +101,409 | $0.00 | +$0 |
| Johannes Jacob Pieter Kastelein | Mar 09 |
Open Market Sale (S)
Market Sale
|
69,302 | -101,409 | $30.29 | -$3,071,678 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| LOUIS G LANGE | Mar 10 |
Open Market Sale (S)
Market Sale
|
0 | -28,186 | $29.41 | -$828,950 |
| Johannes Jacob Pieter Kastelein | Mar 09 |
Option Exercise/Conversion (M)
Compensation/Award
|
163,426 | +94,124 | $0.00 | +$0 |
| Johannes Jacob Pieter Kastelein | Mar 09 |
Open Market Sale (S)
Market Sale
|
69,302 | -94,124 | $30.32 | -$2,853,839 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Johannes Jacob Pieter Kastelein | Mar 09 |
Option Exercise/Conversion (M)
Compensation/Award
|
173,769 | +104,467 | $0.00 | +$0 |
| Johannes Jacob Pieter Kastelein | Mar 09 |
Open Market Sale (S)
Market Sale
|
69,302 | -104,467 | $30.30 | -$3,165,350 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael H. Davidson | Mar 02 |
Open Market Sale (S)
Market Sale
|
174,144 | -443,707 | $33.25 | -$14,753,257 |
| Michael H. Davidson | Mar 02 |
Option Exercise/Conversion (M)
Compensation/Award
|
617,851 | +443,707 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael H. Davidson | Feb 26 |
Option Exercise/Conversion (M)
Compensation/Award
|
643,191 | +183,332 | $0.00 | +$0 |
| Michael H. Davidson | Feb 26 |
Open Market Sale (S)
Market Sale
|
477,783 | -165,408 | $33.63 | -$5,562,671 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael H. Davidson | Feb 26 |
Open Market Sale (S)
Market Sale
|
471,595 | -46,517 | $35.11 | -$1,633,211 |
| Michael H. Davidson | Feb 26 |
Option Exercise/Conversion (M)
Compensation/Award
|
518,112 | +58,253 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael H. Davidson | Feb 26 |
Open Market Sale (S)
Market Sale
|
463,020 | -61,547 | $36.13 | -$2,223,693 |
| Michael H. Davidson | Feb 26 |
Option Exercise/Conversion (M)
Compensation/Award
|
524,567 | +64,708 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Johannes Jacob Pieter Kastelein | Feb 24 |
Open Market Sale (S)
Market Sale
|
84,289 | -14,692 | $35.00 | -$514,220 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Louise Frederika Kooij | Jan 29 |
Open Market Sale (S)
Market Sale
|
24,353 | -32,612 | $31.80 | -$1,037,061 |
| Louise Frederika Kooij | Jan 29 |
Option Exercise/Conversion (M)
Compensation/Award
|
56,965 | +32,612 | $10.90 | +$355,470 |
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