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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Non-cash royalty revenue related to the sales of future royalties | |||||
| Non-cash interest expense on liabilities related to sales of future royalties | |||||
| Loss on revaluation of liability related to the sale of future royalties | |||||
| Change in fair value of development derivative liability | |||||
| Non-cash research and development expense | |||||
| Loss from equity method investment | |||||
| Stock-based compensation | |||||
| Depreciation and amortization | |||||
| Deferred income tax expense | |||||
| Impairment of right-of-use assets and property, plant and equipment | |||||
| Impairment of goodwill | |||||
| Gain on sale of the Huntsville manufacturing facility | |||||
| (Gain) loss on sale or disposal of property, plant and equipment, net | |||||
| Provision for net realizable value of inventory | |||||
| Foreign currency translation adjustment | |||||
| Amortization of premiums (discounts), net and other non-cash transactions | |||||
| Amortization of premiums (discounts), net | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Inventory | |||||
| Operating leases, net | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of investments | |||||
| Maturities of investments | |||||
| Proceeds from sale of the Huntsville manufacturing facility, net | |||||
| Sales of investments | |||||
| Proceeds (payments) relating to the sale of the Huntsville manufacturing facility, net | |||||
| Purchases of property, plant and equipment | |||||
| Sales of property, plant and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Cash receipts from development derivative liability | |||||
| Proceeds from offering, net | |||||
| 2025 Secondary Public Offering | |||||
| At-the-Market Offering | |||||
| Payments of offering costs associated with issuance of common stock | |||||
| Proceeds from issuance of TCG pre-funded warrant | |||||
| Proceeds from sale of future royalties | |||||
| Repurchase of common stock from Bristol-Myers Squibb | |||||
| Proceeds from shares issued under equity compensation plans and TCG pre-funded warrant | |||||
| Net cash provided by financing activities | |||||
| Effect of foreign exchange rates on cash and cash equivalents | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of year | |||||
| Cash and cash equivalents at end of year | |||||
| Non-cash investing and financing activities: | |||||
| Fair value of equity method investment in Gannet BioChem received in exchange for sale of Huntsville manufacturing facility | |||||
| Transaction costs and net working capital adjustment for sale of Huntsville manufacturing facility included in accounts payable and accrued expenses | |||||
| Supplemental disclosure of cash flow information: | |||||
| Operating lease right-of-use assets recognized in exchange for lease liabilities | |||||
| Cash paid (refund) for income taxes, net | |||||
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