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FY2025
12 months to Dec 31, 2025
|
FY2024
12 months to Dec 31, 2024
|
FY2023
12 months to Dec 31, 2023
|
FY2022
12 months to Dec 31, 2022
|
FY2021
12 months to Dec 31, 2021
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|
|---|---|---|---|---|---|
| CASH FLOWS FROM OPERATING ACTIVITIES: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Loss (gain) on disposal of property and equipment | |||||
| Accelerated amortization/impairment of right-of-use assets | |||||
| Stock-based compensation | |||||
| Accretion of investment discounts and premiums | |||||
| Change in fair value of investments, net | |||||
| AvenCell Member | |||||
| Sparing Vision SAS | |||||
| Kyverna | |||||
| Total change in fair value of investments, net | |||||
| (Recognition) deferral of equity method investment intra-entity profit on sales | |||||
| Loss from equity method investment | |||||
| AvenCell Member | |||||
| Total loss from equity method investment | |||||
| Change in fair value of contingent consideration | |||||
| In-process research and development expense | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Prepaid expenses and other current assets | |||||
| Operating lease right-of-use assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses | |||||
| Deferred revenue | |||||
| Operating lease liabilities | |||||
| Net cash used in operating activities | |||||
| CASH FLOWS FROM INVESTING ACTIVITIES: | |||||
| Purchases of property and equipment | |||||
| Purchases of marketable securities | |||||
| Sales and maturities of marketable securities | |||||
| Proceeds from sale of property and equipment | |||||
| Acquired in-process research and development, net of cash acquired of $287 | |||||
| Investment in Kyverna Therapeutics, Inc. | |||||
| Net cash provided by (used in) investing activities | |||||
| CASH FLOWS FROM FINANCING ACTIVITIES: | |||||
| Net proceeds from issuance of common stock | |||||
| At The Market Offerings | |||||
| Follow-on Offering | |||||
| Total net proceeds from issuance of common stock | |||||
| Proceeds from options exercised | |||||
| Issuance of shares through employee stock purchase plan | |||||
| Net cash provided by financing activities | |||||
| Net (decrease) increase in cash, cash equivalents and restricted cash equivalents | |||||
| Cash, cash equivalents and restricted cash equivalents, beginning of period | |||||
| Cash, cash equivalents and restricted cash equivalents, end of period | |||||
| SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION: | |||||
| Purchases of property and equipment unpaid at period end | |||||
| Reduction of right-of-use assets from remeasurement of lease liabilities | |||||
| Operating lease liabilities arising from obtaining right-of-use assets | |||||
| Right-of-use assets acquired under operating leases | |||||
| Non-cash trade-in of property and equipment | |||||
| Non-cash contribution of intellectual property | |||||
| AvenCell Member | |||||
| Sparing Vision SAS | |||||
| Kyverna | |||||
| Proceeds from at-the-market offerings unpaid at period end | |||||
| Shares issued for Rewrite contingent consideration | |||||
| Contingent consideration liability assumed in asset acquisition | |||||
| Reconciliation of cash, cash equivalents and restricted cash equivalents to consolidated balance sheet: | |||||
| Cash and cash equivalents | |||||
| Restricted cash equivalents, included in investments and other assets | |||||
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