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$OPK

$1.43 -$0.03 (2.05%)

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Insider Transactions

Insider Transaction Summary

PHILLIP MD ET AL FROST

216,228,819 shares

Net: +689,935 B/S: ∞

Gamma Investments Trust Frost

190,823,194 shares

Net: 0 B/S: -

Nevada Investments Trust Frost

29,939,818 shares

Net: 0 B/S: -

JANE PH D HSIAO

500,000 shares

Net: 0 B/S: -

Elias A. Zerhouni

500,000 shares

Net: 0 B/S: -

Gary J. Nabel

437,500 shares

Net: 0 B/S: -

Steven D Rubin

437,500 shares

Net: 0 B/S: -

Adam Logal

437,500 shares

Net: 0 B/S: -

JOHN A PAGANELLI

394,340 shares

Net: +10,000 B/S: ∞

Jon R Cohen

125,000 shares

Net: 0 B/S: -

RICHARD C JR PFENNIGER

60,000 shares

Net: 0 B/S: -

SUBBARAO V UPPALURI

50,000 shares

Net: +50,000 B/S: ∞

RICHARD M KRASNO

30,000 shares

Net: 0 B/S: -

Alexis Borisy

30,000 shares

Net: 0 B/S: -

Prem A Lachman

30,000 shares

Net: 0 B/S: -

ROGER MD MEDEL

30,000 shares

Net: 0 B/S: -

RICHARD A LERNER

30,000 shares

Net: 0 B/S: -

Alice Lin-Tsing Yu

30,000 shares

Net: 0 B/S: -

Robert Scott Fishel

30,000 shares

Net: 0 B/S: -

Anthony J Japour

1,000 shares

Net: 0 B/S: -

Insider Name	Current Shares	Net Change (1yr)	Buy/Sell Ratio
PHILLIP MD ET AL FROST	216,228,819	+689,935	∞
Gamma Investments Trust Frost	190,823,194	0	-
Nevada Investments Trust Frost	29,939,818	0	-
JANE PH D HSIAO	500,000	0	-
Elias A. Zerhouni	500,000	0	-
Gary J. Nabel	437,500	0	-
Steven D Rubin	437,500	0	-
Adam Logal	437,500	0	-
JOHN A PAGANELLI	394,340	+10,000	∞
Jon R Cohen	125,000	0	-
RICHARD C JR PFENNIGER	60,000	0	-
SUBBARAO V UPPALURI	50,000	+50,000	∞
RICHARD M KRASNO	30,000	0	-
Alexis Borisy	30,000	0	-
Prem A Lachman	30,000	0	-
ROGER MD MEDEL	30,000	0	-
RICHARD A LERNER	30,000	0	-
Alice Lin-Tsing Yu	30,000	0	-
Robert Scott Fishel	30,000	0	-
Anthony J Japour	1,000	0	-

Individual Transactions

March 20, 2026

JOHN A PAGANELLI

Open Market Purchase

Change: +10,000

Price: $1.14

Shares: 394,340

Value: +$11,350

Insider	Filing Date	Transaction	Shares	Change	Price	Value
JOHN A PAGANELLI	Mar 20	Open Market Purchase (P) Market Purchase	394,340	+10,000	$1.14	+$11,350

March 18, 2026

SUBBARAO V UPPALURI

Grant/Award Acquisition

Change: +50,000

Price: $0.00

Shares: 50,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
SUBBARAO V UPPALURI	Mar 20	Grant/Award Acquisition (A) Compensation/Award	50,000	+50,000	$0.00	+$0

November 21, 2025

PHILLIP MD ET AL FROST

Open Market Purchase

Change: +102,371

Price: $1.30

Shares: 216,228,819

Value: +$133,082

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Nov 21	Open Market Purchase (P) Market Purchase	216,228,819	+102,371	$1.30	+$133,082

November 20, 2025

PHILLIP MD ET AL FROST

Open Market Purchase

Change: +119,129

Price: $1.32

Shares: 215,665,577

Value: +$157,250

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Nov 20	Open Market Purchase (P) Market Purchase	215,665,577	+119,129	$1.32	+$157,250

November 19, 2025

PHILLIP MD ET AL FROST

Open Market Purchase

Change: +36,325

Price: $1.28

Shares: 215,002,773

Value: +$46,496

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Nov 19	Open Market Purchase (P) Market Purchase	215,002,773	+36,325	$1.28	+$46,496

November 18, 2025

PHILLIP MD ET AL FROST

Open Market Purchase

Change: +410

Price: $1.25

Shares: 214,386,858

Value: +$510

PHILLIP MD ET AL FROST

Grant/Award Acquisition

Change: +46,700

Price: $1.26

Shares: 214,549,783

Value: +$58,842

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Nov 18	Open Market Purchase (P) Market Purchase	214,386,858	+410	$1.25	+$510
PHILLIP MD ET AL FROST	Nov 18	Grant/Award Acquisition (A) Compensation/Award	214,549,783	+46,700	$1.26	+$58,842

October 31, 2025

PHILLIP MD ET AL FROST

Open Market Purchase

Change: +150,000

Price: $1.42

Shares: 214,386,448

Value: +$213,435

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Oct 31	Open Market Purchase (P) Market Purchase	214,386,448	+150,000	$1.42	+$213,435

August 18, 2025

PHILLIP MD ET AL FROST

Gift

Change: -440,000

Price: $0.00

Shares: 214,236,448

Value: -$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Aug 19	Gift (G) Non-Market Transfer	214,236,448	-440,000	$0.00	-$0

August 08, 2025

PHILLIP MD ET AL FROST

Open Market Purchase

Change: +675,000

Price: $1.32

Shares: 214,676,448

Value: +$891,000

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	Aug 08	Open Market Purchase (P) Market Purchase	214,676,448	+675,000	$1.32	+$891,000

May 27, 2025

PHILLIP MD ET AL FROST

Grant/Award Acquisition

Change: +500,000

Price: $0.00

Shares: 500,000

Value: +$0

Gary J. Nabel

Grant/Award Acquisition

Change: +437,500

Price: $0.00

Shares: 437,500

Value: +$0

Elias A. Zerhouni

Grant/Award Acquisition

Change: +500,000

Price: $0.00

Shares: 500,000

Value: +$0

Steven D Rubin

Grant/Award Acquisition

Change: +437,500

Price: $0.00

Shares: 437,500

Value: +$0

Adam Logal

Grant/Award Acquisition

Change: +437,500

Price: $0.00

Shares: 437,500

Value: +$0

JANE PH D HSIAO

Grant/Award Acquisition

Change: +500,000

Price: $0.00

Shares: 500,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
PHILLIP MD ET AL FROST	May 29	Grant/Award Acquisition (A) Compensation/Award	500,000	+500,000	$0.00	+$0
Gary J. Nabel	May 29	Grant/Award Acquisition (A) Compensation/Award	437,500	+437,500	$0.00	+$0
Elias A. Zerhouni	May 29	Grant/Award Acquisition (A) Compensation/Award	500,000	+500,000	$0.00	+$0
Steven D Rubin	May 29	Grant/Award Acquisition (A) Compensation/Award	437,500	+437,500	$0.00	+$0
Adam Logal	May 29	Grant/Award Acquisition (A) Compensation/Award	437,500	+437,500	$0.00	+$0
JANE PH D HSIAO	May 29	Grant/Award Acquisition (A) Compensation/Award	500,000	+500,000	$0.00	+$0

April 23, 2025

ROGER MD MEDEL

Grant/Award Acquisition

Change: +30,000

Price: $0.00

Shares: 30,000

Value: +$0

Prem A Lachman

Grant/Award Acquisition

Change: +30,000

Price: $0.00

Shares: 30,000

Value: +$0

Alice Lin-Tsing Yu

Grant/Award Acquisition

Change: +30,000

Price: $0.00

Shares: 30,000

Value: +$0

JOHN A PAGANELLI

Grant/Award Acquisition

Change: +30,000

Price: $0.00

Shares: 30,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
ROGER MD MEDEL	Apr 23	Grant/Award Acquisition (A) Compensation/Award	30,000	+30,000	$0.00	+$0
Prem A Lachman	Apr 23	Grant/Award Acquisition (A) Compensation/Award	30,000	+30,000	$0.00	+$0
Alice Lin-Tsing Yu	Apr 23	Grant/Award Acquisition (A) Compensation/Award	30,000	+30,000	$0.00	+$0
JOHN A PAGANELLI	Apr 23	Grant/Award Acquisition (A) Compensation/Award	30,000	+30,000	$0.00	+$0