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Personalis Inc

personalis.com

What Do They Do?

Sells cancer genomic tests to physicians and pharmaceutical companies, and sequencing services to diagnostic companies and population sequencing programs.

How Do They Make Money?

Customers pay for genomic testing services when Personalis delivers test results; invoices are typically due within 90 days.

FY2025 revenue

Who Are Their Customers?

Personalis sells through a small direct sales force, while Tempus markets NeXT Personal Dx to clinical and biopharma customers. Buyers include pharmaceutical and diagnostic companies, research programs run by government, academic, and nonprofit organizations, and cancer patients.

Customers above 10% of revenue, FY2025
of revenue from two customers (22%, 17%)
FY2024: 37% from two customers

Do Revenues Turn Into Profits?

No. It lost $81.3M in FY2025.

Operating income, FY2025
−126% of revenue
▲ +29% (Loss) vs FY2024 (−$68.3M, −81%)
Net income, FY2025
−117% of revenue
▼ 0% (Loss) vs FY2024 (−$81.3M, −96%)
Free cash flow, FY2025
−114% of revenue
▲ +70% (Loss) vs FY2024 (−$46.8M, −55%)

How Are They Changing?

Since the FY2025 annual report
Latest quarter: Q2 FY2026, the three months to Jun 30, 2026
Revenue
▲ +30%
vs $17.2M in Q2 FY2025
Net income
▲ +58% (Loss)
vs −$20.1M in Q2 FY2025
  • Aug 4, 2026 Personalis says it will no longer provide financial guidance
  • Jul 20, 2026 Tempus agrees to acquire Personalis in a merger Shareholders are to receive Tempus stock, with Tempus able to elect cash for up to 50% of shares.

Shrinking. Revenue fell 19% in 4 years, from $85.5M in FY2021 to $69.6M in FY2025, about 5% a year.

Clinical diagnostics Personalis moved from preparing for expansion in clinical diagnostics to describing tests used by physicians for recurrence monitoring, treatment response, and therapy selection.

Who Do They Compete With?

Competes with Adela, Caris Life Sciences, DELFI Diagnostics, Exact Sciences, Foresight Diagnostics, Foundation Medicine, GRAIL, Guardant Health, Haystack Oncology, Laboratory Corporation of America Holdings, MedGenome, Myriad Genetics, Natera, NeoGenomics, Predicine, SAGA Diagnostics, Veracyte, Illumina, and Thermo Fisher Scientific

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