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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flow from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation expense | |||||
| Depreciation and amortization | |||||
| Noncash lease expense | |||||
| Impairment on right-of use assets | |||||
| Amortization of discounts on marketable securities | |||||
| Effective interest on liability for sale of future royalties | |||||
| Other items, net | |||||
| Changes in operating assets and liabilities: | |||||
| Receivable from collaboration partners ($6, $14 and $19 from a related party) | |||||
| Other assets ($—, $6 and ($4) from a related party) | |||||
| Accounts payable ($24, $—, and $— to a related party) | |||||
| Deferred revenue (($240), ($56) and ($77) to a related party) | |||||
| Other liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flow from investing activities | |||||
| Purchases of marketable securities | |||||
| Proceeds from maturities of marketable securities | |||||
| Proceeds from sales of marketable securities | |||||
| Purchases of property and equipment | |||||
| Purchases of in-process research and development | |||||
| Collaboration reimbursements of in-process research and development from a related party | |||||
| Other items, net | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flow from financing activities | |||||
| Proceeds from issuance of common stock ($14, $228 and $20 from a related party), net | |||||
| Proceeds from debt issuances, net | |||||
| Proceeds from issuance of common stock pursuant to equity award plans | |||||
| Payments of employee taxes related to net settlement of equity awards | |||||
| Proceeds from sale of future royalties | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of period | |||||
| Cash, cash equivalents and restricted cash at end of period | |||||
| Supplemental disclosure of cash flow information | |||||
| Income taxes paid | |||||
| Interest paid | |||||
| Non-cash investing and financing activities: | |||||
| Unpaid portion of property and equipment purchases included in Accounts payable and Other current liabilities | |||||
| Unpaid portion of other assets included in accrued research and development | |||||
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