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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities | |||||
| Stock-based compensation expense | |||||
| Depreciation and amortization | |||||
| Provision for credit losses (recoveries) | |||||
| Net accretion of discounts on marketable debt securities | |||||
| Net realized gain on investments | |||||
| Impairment of long-lived assets | |||||
| Non-cash interest expense | |||||
| Other non-cash adjustments | |||||
| Changes in operating assets and liabilities | |||||
| Accounts receivable | |||||
| Prepaid expenses | |||||
| Other current assets | |||||
| Operating lease right-of-use assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses and other current liabilities | |||||
| Deferred revenue | |||||
| Operating lease liabilities | |||||
| Other liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities | |||||
| Purchases of marketable debt securities | |||||
| Maturities of marketable debt securities | |||||
| Sales of equity securities | |||||
| Purchases of property and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities | |||||
| Proceeds from exercise of stock options | |||||
| Taxes paid related to net settlement of stock-based awards | |||||
| Proceeds from issuance of common stock under employee stock purchase plan | |||||
| Proceeds from public offering of common stock and pre-funded warrants, net of issuance costs | |||||
| Expenses related to at-the-market offering programs | |||||
| Proceeds from issuance of royalty bond and warrants, net of transaction costs | |||||
| Proceeds from private placement of common stock, net of issuance costs | |||||
| Offering expenses related to at-the-market offering programs | |||||
| Repayments under liability related to sale of future royalties, net of imputed interest | |||||
| Repayments under royalty monetization liabilities, net of interest | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash and cash equivalents and restricted cash | |||||
| Cash and cash equivalents and restricted cash | |||||
| Beginning of period | |||||
| End of period | |||||
| Supplemental cash flow information | |||||
| Cash paid (received) for income taxes | |||||
| Cash paid for interest under royalty monetization liabilities | |||||
| Supplemental disclosures of non-cash investing and financing information | |||||
| Purchases of property and equipment in accounts payable and accrued expenses and other current liabilities | |||||
| Proceeds due to Company from sales of non-marketable equity securities | |||||
| Deferred equity offering costs in accounts payable and accrued expenses and other current liabilities | |||||
| Deferred equity offering costs reclassified | |||||
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