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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net (loss) income | |||||
| Adjustments to reconcile net (loss) income to net cash flow from operating activities | |||||
| Non-cash inventory write-downs for excess and obsolescence | |||||
| Stock-based compensation | |||||
| In-kind milestone payment to Arrowhead Pharmaceuticals | |||||
| Depreciation and amortization | |||||
| Loss on investment in Arrowhead Pharmaceuticals | |||||
| Non-cash write-off of prepaid deposits | |||||
| (Gain) loss on debt extinguishment | |||||
| Reduction in the carry amounts of the right of use assets | |||||
| Non-cash interest expense | |||||
| Accretion of investment discount, net | |||||
| Non-cash termination charges | |||||
| Change in the fair value of derivatives | |||||
| Impairment of strategic investments | |||||
| Gain from sale of Priority Review Voucher | |||||
| Other | |||||
| Changes in operating assets and liabilities, net: | |||||
| Decrease (increase) in accounts receivable | |||||
| Increase in inventory | |||||
| Decrease (increase) in manufacturing-related deposits and prepaids | |||||
| (Increase) decrease in other assets | |||||
| Increase (decrease) in deferred revenue | |||||
| Increase (decrease) in accounts payable, accrued expenses, lease liabilities and other liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Maturity and sale of available-for-sale securities | |||||
| Acquisition of strategic investments | |||||
| Proceeds from sale of investment in Arrowhead Pharmaceuticals | |||||
| Purchase of property and equipment | |||||
| Purchase of available-for-sale securities | |||||
| Purchase of intangible assets and other | |||||
| Proceeds from sale of Priority Review Voucher | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Repayment of 2027 Notes, including debt extinguishment costs | |||||
| Repurchases of common stock, net of excise tax | |||||
| Proceeds from issuance of common stock | |||||
| Debt issuance costs for the August 2025 Exchange and December 2025 Exchange (defined in Note 13) | |||||
| Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program | |||||
| Payments related to Revolving Credit Facility | |||||
| Common stock issuance costs | |||||
| Settlement of capped call share options for 2024 Notes | |||||
| Payment on maturity of 2024 Notes | |||||
| Proceeds from 2027 Notes offering, net of commissions | |||||
| Purchase of capped call share options for 2027 Notes | |||||
| Repurchase of 2024 Notes | |||||
| Repayment of principal amount due under 2019 Term Loan | |||||
| Payment on debt extinguishment of 2019 Term Loan | |||||
| Taxes paid related to net share settlement of equity awards | |||||
| Proceeds from sales of common stock, net of offering costs | |||||
| Net cash (used in) provided by financing activities | |||||
| (Decrease) increase in cash and cash equivalents | |||||
| Cash, cash equivalents and restricted cash: | |||||
| Beginning of year | |||||
| End of year | |||||
| Reconciliation of cash, cash equivalents and restricted cash: | |||||
| Cash and cash equivalents | |||||
| Restricted cash in other assets | |||||
| Total cash, cash equivalents and restricted cash | |||||
| Supplemental disclosure of cash flow information: | |||||
| Cash paid during the year for interest | |||||
| Cash paid during the year for income taxes | |||||
| Supplemental schedule of non-cash activities: | |||||
| Non-cash settlement of 2027 Notes in Exchange Transactions (defined in Note 13) | |||||
| Issuance of 2030 Notes in exchange for 2027 Notes | |||||
| Common stock issued for conversion or exchange of 2027 Notes | |||||
| Incremental option value associated with the December 2025 Exchange (defined in Note 13) | |||||
| Contingent consideration liabilities derecognized in connection with adoption of ASU 2025-07 (see Note 2) | |||||
| Capitalized stock-based compensation and depreciation as inventory | |||||
| Reduction in lease liability embedded in CMO agreement due to remeasurement | |||||
| Lease liabilities arising from obtaining right of use assets | |||||
| Intangible assets and property and equipment included in accounts payable and accrued expenses | |||||
| Accrued debt issuance costs for the Exchange Transactions | |||||
| Common stock issued for conversion or exchange of 2024 Notes | |||||
| Lease liabilities terminated | |||||
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