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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
|
FY2023
12 months to Dec 31, 2023
|
FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|
|---|---|---|---|---|---|
| CASH FLOWS FROM OPERATING ACTIVITIES | |||||
| Net loss | |||||
| Series B Non-Voting Convertible Preferred Stock | |||||
| Series A Non-Voting Convertible Preferred Stock | |||||
| Common Stock | |||||
| Total net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Stock-based compensation | |||||
| Acquired in-process research and development | |||||
| Change in fair value of derivative liability | |||||
| Contingent Value Right Liability | |||||
| Forward Contract Liability | |||||
| Gain on sale of in-process research and development asset | |||||
| Lease ROU asset and leasehold improvement impairment loss | |||||
| Loss on disposal of long-lived assets | |||||
| Net (accretion of discount) amortization of premium on marketable securities | |||||
| Interest proceeds from maturities of zero coupon debt securities | |||||
| Amortization of operating lease assets | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other assets | |||||
| Accounts payable | |||||
| Deferred revenue | |||||
| Development receivables | |||||
| Operating lease liabilities | |||||
| Accrued and other liabilities | |||||
| Related party accounts payable | |||||
| Net cash used in operating activities | |||||
| CASH FLOWS FROM INVESTING ACTIVITIES | |||||
| Cash assumed from asset acquisition of Spyre | |||||
| Proceeds from sale of in-process research & development asset | |||||
| Purchases of property and equipment | |||||
| Proceeds from the sale of property plant and equipment | |||||
| Purchases of marketable securities | |||||
| Proceeds from maturities and sales of marketable securities | |||||
| Net cash (used in) provided by investing activities | |||||
| CASH FLOWS FROM FINANCING ACTIVITIES | |||||
| Proceeds from issuance of Series A non-voting convertible preferred stock in connection with private placement, net of placement and other offering costs | |||||
| Proceeds from issuance of private placement, net | |||||
| Series B Non-Voting Convertible Preferred Stock | |||||
| Series A Non-Voting Convertible Preferred Stock | |||||
| Common Stock | |||||
| Total proceeds from issuance of private placement, net | |||||
| Proceeds from issuance of common stock in connection with at-the-market offering program, net of issuance costs | |||||
| Proceeds from issuance of common stock in connection with follow-on offering, net of issuance costs | |||||
| Payment of deferred offering costs in connection with shelf registration | |||||
| Proceeds from issuance of common stock and pre-funded warrants in registered direct offering, net of offering costs | |||||
| Payment of contingent value rights liability | |||||
| Proceeds from employee stock option exercises and employee stock plan purchases | |||||
| Principal payments on finance lease obligation | |||||
| Other financing cash flows | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate on cash, cash equivalents, and restricted cash | |||||
| NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | |||||
| CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | |||||
| Beginning of period | |||||
| End of period | |||||
| Supplemental Disclosure of Non-Cash Investing and Financing Information: | |||||
| Allocation of deferred offering costs against proceeds of issuance of common stock | |||||
| Exchange of Series A non-voting convertible preferred stock for common stock | |||||
| Conversion of non-voting convertible preferred stock into common stock | |||||
| Series B Non-Voting Convertible Preferred Stock | |||||
| Series A Non-Voting Convertible Preferred Stock | |||||
| Total conversion of non-voting convertible preferred stock into common stock | |||||
| Settlement of forward contract liability and issuance of Series A non-voting convertible preferred stock in connection with the asset acquisition of Spyre | |||||
| Leased assets obtained in exchange for lease obligations | |||||
| Reconciliation of Cash, Cash Equivalents, and Restricted Cash Reported in the Statement of Financial Position | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
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