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Super Investors Ishara Investments LP
II

Ishara Investments LP

Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.

Portfolio value
$136M
Positions
41
Quarter ended
June 30, 2026
Filed
August 14, 2026

Reported portfolio value by quarter (3 quarters reported)

$136M $87.5M
Q4 25 Q1 26 Q2 26

$87.5M in Q4 2025 → $136M now. Hover for any quarter.

Holdings

As reported for the quarter ended June 30, 2026. Activity is the change in share count since the prior quarter's filing.

Holding % of portfolio Activity Shares Value
Acadia Pharmaceuticals Inc 7.6% Added 233% 410,000 $10.4M
Xeris Biopharma Holdings Inc 7.2% Added 20% 1,230,000 $9.74M
Biomarin Pharmaceutical Inc 6.0% Added 75% 143,500 $8.21M
PP Praxis Precision Medicines I 5.5% Unchanged 22,550 $7.55M
UP Ultragenyx Pharmaceutical In 5.0% Added 18% 205,000 $6.84M
Agios Pharmaceuticals Inc 4.5% New 164,000 $6.09M
Insmed Inc 4.0% New 51,250 $5.46M
CP Crinetics Pharmaceuticals In 3.9% New 143,500 $5.37M
Zentalis Pharmaceuticals Inc 3.7% Trimmed 17% 1,025,000 $4.97M
Vaxcyte Inc 3.5% Added 43% 82,000 $4.77M
Annexon Inc 3.4% Added 371% 820,000 $4.68M
Travere Therapeutics Inc 3.4% Trimmed 26% 82,000 $4.66M
TP Tonix Pharmaceuticals Hldg C 3.2% New 338,250 $4.32M
Bridgebio Pharma Inc 3.1% New 57,400 $4.28M
Axsome Therapeutics Inc. 2.9% Trimmed 60% 16,400 $4.01M
Contineum Therapeutics Inc 2.5% Added 44% 205,000 $3.36M
Lexicon Pharmaceuticals Inc 2.2% Added 41% 1,271,000 $3.05M
Kura Oncology Inc 2.2% New 276,750 $3.04M
DT Dbv Technologies S A 2.2% Added 80% 184,500 $3.03M
Genmab A/s 2.1% Added 25% 102,500 $2.82M
Cytokinetics Inc 2.1% New 32,800 $2.79M
Mineralys Therapeutics Inc 2.0% Added 25% 102,500 $2.77M
Silence Therapeutics PLC 1.8% Trimmed 61% 55,350 $2.43M
Nuvation Bio Inc 1.5% New 369,000 $2.1M
Wave Life Sciences Ltd 1.4% New 328,000 $1.91M
Nektar Therapeutics 1.4% New 26,650 $1.86M
SR Scholar Rock Hldg Corp 1.2% Trimmed 46% 30,750 $1.69M
Enliven Therapeutics Inc 1.2% New 32,800 $1.66M
Alnylam Pharmaceuticals Inc 1.1% Unchanged 5,125 $1.54M
Beam Therapeutics Inc 1.0% Trimmed 29% 41,000 $1.41M
Sionna Therapeutics Inc 1.0% Added 150% 123,000 $1.35M
Oric Pharmaceuticals Inc 1.0% Added 20% 123,000 $1.33M
NP Newamsterdam Pharma Company 0.9% Unchanged 36,900 $1.25M
Vertex Pharmaceuticals Inc 0.9% New 2,460 $1.22M
Ars Pharmaceuticals Inc 0.8% New 143,490 $1.15M
Monopar Therapeutics Inc 0.8% New 12,300 $1.14M
Erasca Inc 0.6% New 41,000 $751K
Vera Therapeutics Inc 0.3% Trimmed 88% 10,250 $440K
Immatics N.v 0.2% Trimmed 80% 30,750 $311K
Mereo Biopharma Group PLC 0.2% New 768,750 $244K
Gossamer Bio Inc 0.1% Unchanged 820,000 $135K

Timeline of changes

What changed each quarter, from the filings' own share counts. Largest moves first; most recent 2 quarters.

Q2 2026

quarter ended June 30, 2026 · filed August 14, 2026

Company Action Shares changed Value of change % of portfolio
Acadia Pharmaceuticals Inc Added +287,000 +$7.26M 7.6%
PP Praxis Precision Medicines I Exited −20,500 −$6.6M —
Agios Pharmaceuticals Inc New +164,000 +$6.09M 4.5%
Axsome Therapeutics Inc. Trimmed −24,600 −$6.02M 2.9%
Kalvista Pharmaceuticals Inc Exited −276,750 −$5.57M —
Insmed Inc New +51,250 +$5.46M 4.0%
CP Crinetics Pharmaceuticals In New +143,500 +$5.37M 3.9%
AT Amicus Therapeutic Exited −369,000 −$5.34M —
Verastem Inc Exited −820,000 −$4.35M —
TP Tonix Pharmaceuticals Hldg C New +338,250 +$4.32M 3.2%

Showing the 10 largest of 49 changes.

Q1 2026

quarter ended March 31, 2026 · filed May 15, 2026

Company Action Shares changed Value of change % of portfolio
Axsome Therapeutics Inc. New +41,000 +$6.93M 6.6%
PP Praxis Precision Medicines I New +20,500 +$6.6M 6.3%
PP Praxis Precision Medicines I Trimmed −17,450 −$5.62M 6.9%
Kalvista Pharmaceuticals Inc New +276,750 +$5.57M 5.3%
Nuvation Bio Inc Exited −400,000 −$3.58M —
AP Arrowhead Pharmaceuticals In New +55,350 +$3.47M 3.3%
Vera Therapeutics Inc New +82,000 +$3.3M 3.1%
Travere Therapeutics Inc New +110,700 +$3.29M 3.1%
Moonlake Immunotherapeutics New +174,250 +$3.25M 3.1%
Annexon Inc Trimmed −575,750 −$3.19M 0.9%

Showing the 10 largest of 56 changes.

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