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FY2021
12 months to Dec 31, 2021
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FY2020
12 months to Dec 31, 2020
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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Share-based compensation expense | |||||
| Depreciation and amortization | |||||
| Amortization of premiums and discounts on available-for-sale securities | |||||
| Amortization of debt issuance costs | |||||
| Write-off of debt issuance costs related to convertible senior notes transactions | |||||
| Loss on convertible senior notes conversion | |||||
| Loss on extinguishment of debt | |||||
| Loss on sale of property and equipment | |||||
| Legal settlement loss | |||||
| Acquired in-process research and development | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Inventory | |||||
| Prepaid and accrued research and development expenses | |||||
| Other operating assets and liabilities | |||||
| Accounts payable | |||||
| Other accrued expenses | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Purchases of property and equipment | |||||
| Proceeds from sale of property and equipment | |||||
| Purchases of available-for-sale securities | |||||
| Sales of available-for-sale securities | |||||
| Acquired in-process research and development - milestone payment | |||||
| Net cash (used in) provided by investing activities | |||||
| Financing activities | |||||
| Proceeds from sale of common stock, net of issuance costs | |||||
| Proceeds from issuance of convertible senior notes, net of issuance costs | |||||
| Payment of convertible senior notes | |||||
| Extinguishment of convertible senior notes | |||||
| Proceeds from borrowings under financing agreement | |||||
| Proceeds from the exercise of stock options and employee stock purchases | |||||
| Payments on finance leases | |||||
| Payments on other long-term liabilities | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash and cash equivalents | |||||
| (Decrease) increase in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash and cash equivalents at end of period | |||||
| Supplemental disclosure of cash flow information: | |||||
| Cash paid for interest | |||||
| Non-cash investing and financing activities: | |||||
| Vesting of restricted stock units | |||||
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