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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation expense | |||||
| Amortization of held-to-maturity securities, net | |||||
| Amortization of debt issuance costs | |||||
| Gain on investment in Alphazyme | |||||
| Foreign currency exchange loss | |||||
| Changes in operating assets and liabilities: | |||||
| Interest receivable | |||||
| Accounts receivable | |||||
| Prepaid expenses and other current assets | |||||
| Operating lease assets and liabilities, net | |||||
| Accounts payable | |||||
| Accrued expenses | |||||
| Accrued interest | |||||
| Nonrelated Party | |||||
| Related Party | |||||
| Deferred license revenue | |||||
| Accrued interest | |||||
| Accrued interest - related party | |||||
| Deferred research and development obligations | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities | |||||
| Purchases of held-to-maturity investment securities | |||||
| Proceeds from maturities of investment securities | |||||
| Proceeds from the sale of investment in Alphazyme | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities | |||||
| Proceeds from issuance of convertible notes, net of issuance costs | |||||
| Nonrelated Party | |||||
| Related Party | |||||
| Proceeds from public offering, net of offering costs | |||||
| Proceeds from issuance of convertible notes, net of issuance costs | |||||
| Proceeds from issuance of convertible notes, net of issuance costs - related party | |||||
| Proceeds from exercise of options | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash | |||||
| Net decrease in cash, cash equivalents and restricted cash | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash, cash equivalents and restricted cash at end of period | |||||
| Reconciliation of cash, cash equivalents, and restricted cash to the consolidated balance sheets | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
| Total cash, cash equivalents, and restricted cash | |||||
| Supplemental cash flow information | |||||
| Vesting of restricted stock units | |||||
| Conversion of convertible notes | |||||
| Cash paid for interest | |||||
| Right-of-use asset obtained in exchange for lease obligations | |||||
| Supplemental noncash investing and financing information | |||||
| Fair value of warrants issued in connection with the offering | |||||
| Purchase and assignment of convertible note by related party | |||||
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