$IONS
IONIS PHARMACEUTICALS INC Stock $ions

$ions Overview Financials Valuation SEC Filings Company Website

2024 Q1 Form 10-K Financial Statement

#000087401524000116 Filed on February 21, 2024

Income Statement

Concept	2024 Q1	2023 Q4	2023
Revenue	$119.5M	$324.5M	$787.6M
YoY Change	-8.45%	113.64%	34.1%
Cost Of Revenue	$2.151M	$3.000M	$9.133M
YoY Change	60.16%	-18.61%	-35.3%
Gross Profit	$117.3M	$322.0M	$778.5M
YoY Change	-9.16%	117.27%	35.81%
Gross Profit Margin	98.2%	99.23%	98.84%
Selling, General & Admin	$52.64M	$71.00M	$232.6M
YoY Change	15.66%	48.07%	54.77%
% of Gross Profit	44.86%	22.05%	29.88%
Research & Development	$214.2M	$257.0M	$900.0M
YoY Change	8.29%	-16.63%	8.02%
% of Gross Profit	182.55%	79.81%	115.6%
Depreciation & Amortization	$2.547M	$3.251M	$10.29M
YoY Change	-2.19%	-10.61%	-28.17%
% of Gross Profit	2.17%	1.01%	1.32%
Operating Expenses	$52.64M	$328.0M	$232.6M
YoY Change	15.66%	-7.92%	54.77%
Operating Profit	-$149.5M	-$6.122M	-$353.7M
YoY Change	30.98%	-97.06%	-13.76%
Interest Expense	$4.151M	-$18.00M	$12.66M
YoY Change	158.15%	-233.97%	55.87%
% of Operating Profit
Other Income/Expense, Net	$277.0K	$21.00M	$14.26M
YoY Change	20.43%	3135.75%	-295.99%
Pretax Income	-$142.7M	-$3.000M	-$334.0M
YoY Change	26.37%	-93.23%	29.45%
Income Tax	$100.0K	$6.000M	$32.32M
% Of Pretax Income
Net Earnings	-$142.8M	-$9.263M	-$366.3M
YoY Change	14.86%	-82.33%	35.8%
Net Earnings / Revenue	-119.5%	-2.85%	-46.5%
Basic Earnings Per Share	-$0.98	-$0.06	-$2.56
Diluted Earnings Per Share	-$0.98	-$0.06	-$2.56
COMMON SHARES
Basic Shares Outstanding	145.8M	143.5M	143.2M
Diluted Shares Outstanding	145.5M		143.2M

Balance Sheet

Concept	2024 Q1	2023 Q4	2023
SHORT-TERM ASSETS
Cash & Short-Term Investments	$1.652B	$1.711B	$2.331B
YoY Change	-7.33%	14.96%	17.32%
Cash & Equivalents	$348.9M	$399.3M	$2.331B
Short-Term Investments	$1.303B	$1.311B	$1.932B
Other Short-Term Assets	$174.1M	$184.4M	$213.0M
YoY Change	8.98%	9.63%	26.59%
Inventory	$30.26M	$28.43M	$28.43M
Prepaid Expenses
Receivables	$5.140M	$98.00M	$98.00M
Other Receivables	$0.00	$0.00	$0.00
Total Short-Term Assets	$2.416B	$2.642B	$2.642B
YoY Change	-4.99%	19.94%	19.94%
LONG-TERM ASSETS
Property, Plant & Equipment	$72.80M	$71.04M	$243.0M
YoY Change	-14.52%	-4.38%	-5.02%
Goodwill
YoY Change
Intangibles
YoY Change
Long-Term Investments
YoY Change
Other Assets	$106.0M	$105.3M	$105.0M
YoY Change	35.42%	39.73%	39.36%
Total Long-Term Assets	$348.3M	$348.2M	$348.0M
YoY Change	1.65%	5.14%	5.08%
TOTAL ASSETS
Total Short-Term Assets	$2.416B	$2.642B	$2.642B
Total Long-Term Assets	$348.3M	$348.2M	$348.0M
Total Assets	$2.764B	$2.990B	$2.990B
YoY Change	-4.2%	18.0%	18.0%
SHORT-TERM LIABILITIES
YoY Change
Accounts Payable	$13.08M	$26.03M	$26.03M
YoY Change	24.6%	45.23%	45.23%
Accrued Expenses	$106.0M	$147.9M	$223.7M
YoY Change	-5.9%	5.56%	13.85%
Deferred Revenue	$130.4M	$151.1M
YoY Change	41.23%	66.85%
Short-Term Debt	$0.00	$0.00	$0.00
YoY Change
Long-Term Debt Due	$44.38M	$157.0K	$44.00M
YoY Change	438.62%	3.97%	13650.0%
Total Short-Term Liabilities	$327.6M	$448.1M	$448.0M
YoY Change	26.4%	43.82%	43.79%
LONG-TERM LIABILITIES
Long-Term Debt	$1.231B	$1.241B	$1.229B
YoY Change	3.93%	5.55%	3.91%
Other Long-Term Liabilities	$41.80M	$926.0M	$926.0M
YoY Change	458.3%	12894.67%	98.41%
Total Long-Term Liabilities	$41.80M	$1.241B	$2.155B
YoY Change	458.3%	4.92%	30.65%
TOTAL LIABILITIES
Total Short-Term Liabilities	$327.6M	$448.1M	$448.0M
Total Long-Term Liabilities	$41.80M	$1.241B	$2.155B
Total Liabilities	$2.467B	$2.603B	$2.603B
YoY Change	2.87%	32.76%	32.74%
SHAREHOLDERS EQUITY
Retained Earnings	-$1.939B	-$1.796B
YoY Change	24.76%	25.62%
Common Stock	$2.270B	$2.215B
YoY Change	8.65%	7.54%
Preferred Stock
YoY Change
Treasury Stock (at cost)
YoY Change
Treasury Stock Shares
Shareholders Equity	$296.5M	$386.7M	$387.0M
YoY Change
Total Liabilities & Shareholders Equity	$2.764B	$2.990B	$2.990B
YoY Change	-4.2%	18.0%	18.0%

Cashflow Statement

Concept	2024 Q1	2023 Q4	2023
OPERATING ACTIVITIES
Net Income	-$142.8M	-$9.263M	-$366.3M
YoY Change	14.86%	-82.33%	35.8%
Depreciation, Depletion And Amortization	$2.547M	$3.251M	$10.29M
YoY Change	-2.19%	-10.61%	-28.17%
Cash From Operating Activities	-$149.9M	$32.89M	-$307.5M
YoY Change	11.9%	-116.43%	12.08%
INVESTING ACTIVITIES
Capital Expenditures	$4.493M	-$795.0K	$23.81M
YoY Change	-57.1%	-119.21%	51.42%
Acquisitions
YoY Change
Other Investing Activities	$80.60M	-$27.52M	-$190.3M
YoY Change	-125.57%	-112.72%	-22.92%
Cash From Investing Activities	$76.11M	-$26.73M	-$214.1M
YoY Change	-123.37%	-112.6%	-18.47%
FINANCING ACTIVITIES
Cash Dividend Paid
YoY Change
Common Stock Issuance & Retirement, Net
YoY Change
Debt Paid & Issued, Net
YoY Change
Cash From Financing Activities	23.57M	40.68M	644.1M
YoY Change	-95.21%	-179.74%	-1264.81%
NET CHANGE
Cash From Operating Activities	-149.9M	32.89M	-307.5M
Cash From Investing Activities	76.11M	-26.73M	-214.1M
Cash From Financing Activities	23.57M	40.68M	644.1M
Net Change In Cash	-50.38M	46.84M	122.8M
YoY Change	-254.73%	-219.9%	-120.72%
FREE CASH FLOW
Cash From Operating Activities	-$149.9M	$32.89M	-$307.5M
Capital Expenditures	$4.493M	-$795.0K	$23.81M
Free Cash Flow	-$154.4M	$33.68M	-$331.3M
YoY Change	6.9%	-116.48%	14.21%

Facts In Submission

Frame	Concept Type	Concept / XBRL Key	Value
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CY2022Q4	us-gaap	Contract With Customer Asset Net Current ContractWithCustomerAssetNetCurrent	25538000
CY2023Q4	us-gaap	Inventory Net InventoryNet	28425000
CY2023Q4	us-gaap	Other Assets Current OtherAssetsCurrent	184449000
CY2023Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	71043000
CY2023Q4	us-gaap	Assets Assets	2990072000
CY2023Q4	us-gaap	Accounts Payable Current AccountsPayableCurrent	26027000
CY2022Q4	us-gaap	Accounts Payable Current AccountsPayableCurrent	17921000
CY2022Q4	us-gaap	Liabilities Current LiabilitiesCurrent	311561000
CY2023Q4	us-gaap	Contract With Customer Liability Noncurrent ContractWithCustomerLiabilityNoncurrent	241184000
CY2022Q4	us-gaap	Contract With Customer Liability Noncurrent ContractWithCustomerLiabilityNoncurrent	287768000
CY2023Q4	us-gaap	Long Term Loans From Bank LongTermLoansFromBank	41836000
CY2022Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.001
CY2023Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.001
CY2022Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	300000000
CY2023Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	300000000
CY2023Q4	us-gaap	Common Stock Shares Outstanding CommonStockSharesOutstanding	144340526
CY2023Q4	us-gaap	Common Stock Shares Issued CommonStockSharesIssued	144340526
CY2022Q4	us-gaap	Common Stock Shares Outstanding CommonStockSharesOutstanding	142057736
CY2023	us-gaap	Interest Expense InterestExpense	12660000
CY2022	us-gaap	Interest Expense InterestExpense	8122000
CY2021	us-gaap	Interest Expense InterestExpense	9349000
CY2023	us-gaap	Gain Loss On Investments GainLossOnInvestments	-1914000
CY2022	us-gaap	Gain Loss On Investments GainLossOnInvestments	-7333000
CY2021	us-gaap	Gain Loss On Investments GainLossOnInvestments	10103000
CY2023	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	14256000
CY2022	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	-7274000
CY2021	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	-9760000
CY2023	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-333965000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-257985000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-29148000
CY2023	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	32321000
CY2022	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	11737000
CY2021	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-551000
CY2023	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-2.56
CY2022	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-1.9
CY2022	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	141848000
CY2023Q4	us-gaap	Retained Earnings Accumulated Deficit RetainedEarningsAccumulatedDeficit	-1795911000
CY2021	us-gaap	Cost Of Goods And Services Sold CostOfGoodsAndServicesSold	10842000
CY2022	us-gaap	Depreciation Depreciation	14328000
CY2021	us-gaap	Depreciation Depreciation	15487000
CY2021	us-gaap	Amortization Of Intangible Assets AmortizationOfIntangibleAssets	2352000
CY2021	us-gaap	Amortization Of Financing Costs AmortizationOfFinancingCosts	4958000
CY2021	us-gaap	Share Based Compensation ShareBasedCompensation	120678000
CY2023	us-gaap	Gains Losses On Extinguishment Of Debt GainsLossesOnExtinguishmentOfDebt	13389000
CY2022	us-gaap	Gains Losses On Extinguishment Of Debt GainsLossesOnExtinguishmentOfDebt	0
CY2023	us-gaap	Realized Investment Gains Losses RealizedInvestmentGainsLosses	-1589000
CY2022	us-gaap	Realized Investment Gains Losses RealizedInvestmentGainsLosses	-224000
CY2021	us-gaap	Realized Investment Gains Losses RealizedInvestmentGainsLosses	1092000
CY2023	us-gaap	Impairment Of Intangible Assets Finitelived ImpairmentOfIntangibleAssetsFinitelived	1661000
CY2021	us-gaap	Impairment Of Intangible Assets Finitelived ImpairmentOfIntangibleAssetsFinitelived	2707000
CY2023	us-gaap	Increase Decrease In Contract With Customer Asset IncreaseDecreaseInContractWithCustomerAsset	72059000
CY2021	us-gaap	Increase Decrease In Contract With Customer Asset IncreaseDecreaseInContractWithCustomerAsset	-14308000
CY2023	us-gaap	Increase Decrease In Income Taxes Payable Net Of Income Taxes Receivable IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable	-4098000
CY2022	us-gaap	Increase Decrease In Income Taxes Payable Net Of Income Taxes Receivable IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable	6213000
CY2023	us-gaap	Increase Decrease In Contract With Customer Liability IncreaseDecreaseInContractWithCustomerLiability	13967000
CY2022	us-gaap	Increase Decrease In Contract With Customer Liability IncreaseDecreaseInContractWithCustomerLiability	-71248000
CY2021	us-gaap	Increase Decrease In Contract With Customer Liability IncreaseDecreaseInContractWithCustomerLiability	-82829000
CY2023	us-gaap	Net Cash Provided By Used In Operating Activities NetCashProvidedByUsedInOperatingActivities	-307513000
CY2022	us-gaap	Net Cash Provided By Used In Operating Activities NetCashProvidedByUsedInOperatingActivities	-274370000
CY2021	us-gaap	Net Cash Provided By Used In Operating Activities NetCashProvidedByUsedInOperatingActivities	30799000
CY2022	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	15721000
CY2021	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	11955000
CY2023	us-gaap	Payments To Acquire Intangible Assets PaymentsToAcquireIntangibleAssets	4206000
CY2022	us-gaap	Payments To Acquire Intangible Assets PaymentsToAcquireIntangibleAssets	4378000
CY2021	us-gaap	Payments To Acquire Intangible Assets PaymentsToAcquireIntangibleAssets	5946000
CY2023	us-gaap	Payments To Acquire Other Investments PaymentsToAcquireOtherInvestments	0
CY2022	us-gaap	Payments To Acquire Other Investments PaymentsToAcquireOtherInvestments	0
CY2021	us-gaap	Payments To Acquire Other Investments PaymentsToAcquireOtherInvestments	7185000
CY2022	us-gaap	Payments Related To Tax Withholding For Share Based Compensation PaymentsRelatedToTaxWithholdingForShareBasedCompensation	10953000
CY2021	us-gaap	Payments Related To Tax Withholding For Share Based Compensation PaymentsRelatedToTaxWithholdingForShareBasedCompensation	16725000
CY2023	us-gaap	Repayments Of Convertible Debt RepaymentsOfConvertibleDebt	0
CY2022	us-gaap	Repayments Of Convertible Debt RepaymentsOfConvertibleDebt	0
CY2021	us-gaap	Repayments Of Convertible Debt RepaymentsOfConvertibleDebt	61967000
CY2023	us-gaap	Proceeds From Issuance Of Warrants ProceedsFromIssuanceOfWarrants	0
CY2022	us-gaap	Proceeds From Issuance Of Warrants ProceedsFromIssuanceOfWarrants	0
CY2021	us-gaap	Proceeds From Issuance Of Warrants ProceedsFromIssuanceOfWarrants	89752000
CY2023	us-gaap	Payments For Hedge Financing Activities PaymentsForHedgeFinancingActivities	0
CY2022	us-gaap	Payments For Hedge Financing Activities PaymentsForHedgeFinancingActivities	0
CY2021	us-gaap	Payments For Hedge Financing Activities PaymentsForHedgeFinancingActivities	136620000
CY2023	us-gaap	Net Cash Provided By Used In Financing Activities NetCashProvidedByUsedInFinancingActivities	644082000
CY2022	us-gaap	Net Cash Provided By Used In Financing Activities NetCashProvidedByUsedInFinancingActivities	-55295000
CY2023	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	143190000
CY2023	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax	351000
CY2023	us-gaap	Depreciation Depreciation	10292000
CY2023	us-gaap	Accretion Amortization Of Discounts And Premiums Investments AccretionAmortizationOfDiscountsAndPremiumsInvestments	28885000
CY2022Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	74294000
CY2023	us-gaap	Operating Income Loss OperatingIncomeLoss	-353730000
CY2021	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	141021000
CY2020Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	397664000
CY2023	us-gaap	Interest Paid Net InterestPaidNet	6512000
CY2022	us-gaap	Interest Paid Net InterestPaidNet	2898000
CY2023	us-gaap	Income Taxes Paid IncomeTaxesPaid	48334000
CY2022	us-gaap	Income Taxes Paid IncomeTaxesPaid	5010000
CY2021	us-gaap	Income Taxes Paid IncomeTaxesPaid	38000
CY2022	us-gaap	Amortization Of Financing Costs AmortizationOfFinancingCosts	5373000
CY2023	us-gaap	Share Based Compensation ShareBasedCompensation	105809000
CY2021	us-gaap	Gains Losses On Extinguishment Of Debt GainsLossesOnExtinguishmentOfDebt	-8627000
CY2022	us-gaap	Increase Decrease In Contract With Customer Asset IncreaseDecreaseInContractWithCustomerAsset	-36358000
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CY2022	us-gaap	Right Of Use Asset Obtained In Exchange For Operating Lease Liability RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability	168931000
CY2021	us-gaap	Right Of Use Asset Obtained In Exchange For Operating Lease Liability RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability	6641000
CY2023	ions	Non Cash Capital And Patent Expenditures NonCashCapitalAndPatentExpenditures	172000
CY2022	ions	Non Cash Capital And Patent Expenditures NonCashCapitalAndPatentExpenditures	4767000
CY2021	ions	Non Cash Capital And Patent Expenditures NonCashCapitalAndPatentExpenditures	705000
CY2023Q4	ions	Debt Instrument Number Of Convertible Notes DebtInstrumentNumberOfConvertibleNotes	3
CY2023	ions	Maximum Contract Maturity Period Range1 MaximumContractMaturityPeriodRange1	P1Y
CY2023Q4	ions	Available For Sale Securities Debt Maturities Within One Year Percentage AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage	0.68
CY2023	ions	Maximum Contract Maturity Period Range1 MaximumContractMaturityPeriodRange1	P1Y
CY2023	ions	Maximum Contract Maturity Period Range2 MaximumContractMaturityPeriodRange2	P2Y
CY2023Q4	ions	Available For Sale Securities Debt Maturities After One Through Two Years Percentage AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage	0.24
CY2023	ions	Maximum Contract Maturity Period Range2 MaximumContractMaturityPeriodRange2	P2Y
CY2023Q4	ions	Available For Sale Securities Debt Maturities After Two Through Three And One Half Years Percentage AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeAndOneHalfYearsPercentage	0.08
CY2023Q4	ions	Available For Sale Securities Debt Maturities Total Percentage AvailableForSaleSecuritiesDebtMaturitiesTotalPercentage	1
CY2023Q4	ions	Available For Sale Securities Debt Maturities Within Two Years Percentage AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage	0.92
CY2023	ions	Maximum Contract Maturity Period Range2 MaximumContractMaturityPeriodRange2	P2Y
CY2023Q4	ions	Number Of Privately Held Companies In Which Entity Has Equity Investment NumberOfPrivatelyHeldCompaniesInWhichEntityHasEquityInvestment	7
CY2023Q4	ions	Number Of Publicly Held Companies In Which Entity Has Equity Investment NumberOfPubliclyHeldCompaniesInWhichEntityHasEquityInvestment	3
CY2023Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni Cost DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiCost	2002859000
CY2023Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni Gross Unrealized Gain DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedGain	28715000
CY2023Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni Gross Unrealized Loss DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedLoss	17392000
CY2023Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNi	2014182000
CY2022Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni Cost DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiCost	1783848000
CY2023	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	23805000
CY2021	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	11565000
CY2022Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni Gross Unrealized Gain DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedGain	17451000
CY2022Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni Gross Unrealized Loss DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedLoss	28997000
CY2022Q4	ions	Debt Securities Available For Sale And Equity Securities Fv Ni DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNi	1772302000
CY2022Q4	ions	Long Term Obligations Noncurrent LongTermObligationsNoncurrent	1361660000
CY2017	ions	Number Of Purchased Facilities Financed With Mortgage Debt NumberOfPurchasedFacilitiesFinancedWithMortgageDebt	2
CY2023	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-333965000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-257985000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-29148000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Foreign IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign	508000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Foreign IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign	818000
CY2021	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	-551000
CY2023	us-gaap	Deferred Federal Income Tax Expense Benefit DeferredFederalIncomeTaxExpenseBenefit	0
CY2022	us-gaap	Deferred Federal Income Tax Expense Benefit DeferredFederalIncomeTaxExpenseBenefit	0
CY2021	us-gaap	Deferred Federal Income Tax Expense Benefit DeferredFederalIncomeTaxExpenseBenefit	0
CY2023	us-gaap	Deferred State And Local Income Tax Expense Benefit DeferredStateAndLocalIncomeTaxExpenseBenefit	0
CY2022	us-gaap	Deferred State And Local Income Tax Expense Benefit DeferredStateAndLocalIncomeTaxExpenseBenefit	0
CY2021	us-gaap	Deferred State And Local Income Tax Expense Benefit DeferredStateAndLocalIncomeTaxExpenseBenefit	0
CY2023	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	0
CY2022	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	0
CY2021	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	0
CY2022	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	11737000
CY2021	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-551000
CY2023	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-333965000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-257985000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-29148000
CY2023	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-70133000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential	0
CY2023	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.21
CY2022	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-54177000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.21
CY2021	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-6121000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.21
CY2023	us-gaap	Income Tax Reconciliation State And Local Income Taxes IncomeTaxReconciliationStateAndLocalIncomeTaxes	-22597000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation State And Local Income Taxes EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes	0.068
CY2021	us-gaap	Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost	4720000
CY2023Q4	ions	Deferred Tax Assets Financing Arrangements DeferredTaxAssetsFinancingArrangements	16849000
CY2022Q4	ions	Deferred Tax Assets Financing Arrangements DeferredTaxAssetsFinancingArrangements	34384000
CY2023Q4	us-gaap	Deferred Tax Assets Gross DeferredTaxAssetsGross	1025713000
CY2022Q4	us-gaap	Deferred Tax Assets Gross DeferredTaxAssetsGross	858014000
CY2023Q4	us-gaap	Deferred Tax Liabilities Property Plant And Equipment DeferredTaxLiabilitiesPropertyPlantAndEquipment	4166000
CY2022Q4	us-gaap	Deferred Tax Liabilities Property Plant And Equipment DeferredTaxLiabilitiesPropertyPlantAndEquipment	4475000
CY2023	us-gaap	Valuation Allowances And Reserves Period Increase Decrease ValuationAllowancesAndReservesPeriodIncreaseDecrease	169000000
CY2022Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	56567000
CY2021Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	55085000
CY2020Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	54163000
CY2023	us-gaap	Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions	737000
CY2022	us-gaap	Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions	267000
CY2021	us-gaap	Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions	695000
CY2023	us-gaap	Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions	429000
CY2022	us-gaap	Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions	259000
CY2023	us-gaap	Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions	2032000
CY2022	us-gaap	Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions	1490000
CY2021	us-gaap	Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions	1354000
CY2021Q4	us-gaap	Unrecognized Tax Benefits That Would Impact Effective Tax Rate UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate	6200000
CY2022	us-gaap	Unrecognized Tax Benefits Income Tax Penalties And Interest Expense UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense	800000
CY2023Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	43298000
CY2022Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	56567000
CY2021Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	55085000
CY2023Q4	us-gaap	Unrecognized Tax Benefits That Would Impact Effective Tax Rate UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate	300000
CY2022Q4	us-gaap	Unrecognized Tax Benefits That Would Impact Effective Tax Rate UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate	6200000
CY2021	us-gaap	Income Tax Reconciliation Nondeductible Expense Other IncomeTaxReconciliationNondeductibleExpenseOther	84000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost	-0.059
CY2023Q4	ions	Deferred Tax Assets Liabilities Net Before Valuation Allowance DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance	977630000
CY2023	ions	Maximum Contract Maturity Period Range3 MaximumContractMaturityPeriodRange3	P3Y6M
CY2023Q4	us-gaap	Operating Lease Liability Current Statement Of Financial Position Extensible List OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList	http://fasb.org/us-gaap/2023#OtherLiabilitiesCurrent
CY2023Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	399266000
CY2022Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	276472000
CY2022Q4	us-gaap	Inventory Net InventoryNet	22033000
CY2023Q4	us-gaap	Assets Current AssetsCurrent	2641853000
CY2022Q4	us-gaap	Other Assets Noncurrent OtherAssetsNoncurrent	75344000
CY2022Q4	us-gaap	Assets Assets	2533876000
CY2023Q4	us-gaap	Employee Related Liabilities Current EmployeeRelatedLiabilitiesCurrent	67727000
CY2022Q4	us-gaap	Employee Related Liabilities Current EmployeeRelatedLiabilitiesCurrent	49178000
CY2023Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	147894000
CY2022Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	140101000
CY2023Q4	us-gaap	Accrued Income Taxes Current AccruedIncomeTaxesCurrent	2151000
CY2022Q4	us-gaap	Accrued Income Taxes Current AccruedIncomeTaxesCurrent	6249000
CY2023Q4	us-gaap	Contract With Customer Liability Current ContractWithCustomerLiabilityCurrent	151128000
CY2022Q4	us-gaap	Contract With Customer Liability Current ContractWithCustomerLiabilityCurrent	90577000
CY2023Q4	us-gaap	Other Liabilities Current OtherLiabilitiesCurrent	8831000
CY2022Q4	us-gaap	Other Liabilities Current OtherLiabilitiesCurrent	7535000
CY2023Q4	us-gaap	Liabilities Current LiabilitiesCurrent	448090000
CY2023Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	170875000
CY2022Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	178941000
CY2022Q4	us-gaap	Long Term Loans From Bank LongTermLoansFromBank	15973000
CY2023Q4	us-gaap	Liabilities Liabilities	2603386000
CY2022Q4	us-gaap	Liabilities Liabilities	1960989000
CY2022Q4	us-gaap	Common Stock Shares Issued CommonStockSharesIssued	142057736
CY2023Q4	us-gaap	Common Stock Value CommonStockValue	144000
CY2022Q4	us-gaap	Common Stock Value CommonStockValue	142000
CY2023Q4	us-gaap	Additional Paid In Capital Common Stock AdditionalPaidInCapitalCommonStock	2215098000
CY2022Q4	us-gaap	Additional Paid In Capital Common Stock AdditionalPaidInCapitalCommonStock	2059850000
CY2023Q4	us-gaap	Stockholders Equity StockholdersEquity	386686000
CY2022Q4	us-gaap	Stockholders Equity StockholdersEquity	572887000
CY2023Q4	us-gaap	Liabilities And Stockholders Equity LiabilitiesAndStockholdersEquity	2990072000
CY2022Q4	us-gaap	Liabilities And Stockholders Equity LiabilitiesAndStockholdersEquity	2533876000
CY2023	us-gaap	Revenue From Contract With Customer Excluding Assessed Tax RevenueFromContractWithCustomerExcludingAssessedTax	787647000
CY2022	us-gaap	Revenue From Contract With Customer Excluding Assessed Tax RevenueFromContractWithCustomerExcludingAssessedTax	587367000
CY2021	us-gaap	Revenue From Contract With Customer Excluding Assessed Tax RevenueFromContractWithCustomerExcludingAssessedTax	810456000
CY2023	us-gaap	Cost Of Goods And Services Sold CostOfGoodsAndServicesSold	9133000
CY2022	us-gaap	Cost Of Goods And Services Sold CostOfGoodsAndServicesSold	14116000
CY2023	ions	Research Development And Patent Expense ResearchDevelopmentAndPatentExpense	899625000
CY2022	ions	Research Development And Patent Expense ResearchDevelopmentAndPatentExpense	833147000
CY2021	ions	Research Development And Patent Expense ResearchDevelopmentAndPatentExpense	643453000
CY2023	us-gaap	Selling General And Administrative Expense SellingGeneralAndAdministrativeExpense	232619000
CY2022	us-gaap	Selling General And Administrative Expense SellingGeneralAndAdministrativeExpense	150295000
CY2021	us-gaap	Selling General And Administrative Expense SellingGeneralAndAdministrativeExpense	186347000
CY2023	us-gaap	Costs And Expenses CostsAndExpenses	1141377000
CY2021	us-gaap	Costs And Expenses CostsAndExpenses	840642000
CY2023	us-gaap	Investment Income Net InvestmentIncomeNet	89041000
CY2022	us-gaap	Investment Income Net InvestmentIncomeNet	25331000
CY2021	us-gaap	Investment Income Net InvestmentIncomeNet	10044000
CY2023	us-gaap	Gain Loss On Disposition Of Assets1 GainLossOnDispositionOfAssets1	-161000
CY2022	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-1.9
CY2021	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.2
CY2021	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-0.2
CY2023	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	143190000
CY2022	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax	-417000
CY2021	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax	-111000
CY2022	us-gaap	Accretion Amortization Of Discounts And Premiums Investments AccretionAmortizationOfDiscountsAndPremiumsInvestments	-7389000
CY2021	us-gaap	Accretion Amortization Of Discounts And Premiums Investments AccretionAmortizationOfDiscountsAndPremiumsInvestments	-17776000
CY2023	us-gaap	Amortization Of Financing Costs AmortizationOfFinancingCosts	6330000
CY2022	us-gaap	Gain Loss On Disposition Of Assets GainLossOnDispositionOfAssets	-531000
CY2021	us-gaap	Gain Loss On Disposition Of Assets GainLossOnDispositionOfAssets	0
CY2023	us-gaap	Sale And Leaseback Transaction Gain Loss Net SaleAndLeasebackTransactionGainLossNet	-161000
CY2021	us-gaap	Increase Decrease In Other Operating Assets IncreaseDecreaseInOtherOperatingAssets	877000
CY2023	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	8119000
CY2022	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	1094000
CY2021	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	-6000000
CY2021	us-gaap	Increase Decrease In Income Taxes Payable Net Of Income Taxes Receivable IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable	-280000
CY2023	us-gaap	Increase Decrease In Other Employee Related Liabilities IncreaseDecreaseInOtherEmployeeRelatedLiabilities	18549000
CY2022	us-gaap	Increase Decrease In Other Employee Related Liabilities IncreaseDecreaseInOtherEmployeeRelatedLiabilities	10368000
CY2021	us-gaap	Increase Decrease In Other Employee Related Liabilities IncreaseDecreaseInOtherEmployeeRelatedLiabilities	-26918000
CY2023	us-gaap	Payments To Acquire Available For Sale Securities Debt PaymentsToAcquireAvailableForSaleSecuritiesDebt	1770814000
CY2022	us-gaap	Payments To Acquire Available For Sale Securities Debt PaymentsToAcquireAvailableForSaleSecuritiesDebt	1485772000
CY2021	us-gaap	Payments To Acquire Available For Sale Securities Debt PaymentsToAcquireAvailableForSaleSecuritiesDebt	1124193000
CY2023	us-gaap	Proceeds From Sale And Maturity Of Available For Sale Securities ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities	1584676000
CY2023	us-gaap	Proceeds From Sale Of Property Plant And Equipment ProceedsFromSaleOfPropertyPlantAndEquipment	22000
CY2022	us-gaap	Proceeds From Sale Of Property Plant And Equipment ProceedsFromSaleOfPropertyPlantAndEquipment	254083000
CY2021	us-gaap	Proceeds From Sale Of Property Plant And Equipment ProceedsFromSaleOfPropertyPlantAndEquipment	0
CY2023	us-gaap	Net Cash Provided By Used In Investing Activities NetCashProvidedByUsedInInvestingActivities	-214127000
CY2022	us-gaap	Net Cash Provided By Used In Investing Activities NetCashProvidedByUsedInInvestingActivities	-262636000
CY2021	us-gaap	Net Cash Provided By Used In Investing Activities NetCashProvidedByUsedInInvestingActivities	194906000
CY2023	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	49442000
CY2022	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	6373000
CY2023	us-gaap	Payments Related To Tax Withholding For Share Based Compensation PaymentsRelatedToTaxWithholdingForShareBasedCompensation	0
CY2023	us-gaap	Repayments Of Secured Debt RepaymentsOfSecuredDebt	160000
CY2022	us-gaap	Repayments Of Secured Debt RepaymentsOfSecuredDebt	50686000
CY2021	us-gaap	Repayments Of Secured Debt RepaymentsOfSecuredDebt	0
CY2021	us-gaap	Net Cash Provided By Used In Financing Activities NetCashProvidedByUsedInFinancingActivities	245933000
CY2023	us-gaap	Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations	352000
CY2022	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect	-592719000
CY2021	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect	471527000
CY2022Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	276472000
CY2021Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	869191000
CY2021	us-gaap	Interest Paid Net InterestPaidNet	4778000
CY2023	us-gaap	Contract With Customer Liability Revenue Recognized ContractWithCustomerLiabilityRevenueRecognized	78200000
CY2022	us-gaap	Contract With Customer Liability Revenue Recognized ContractWithCustomerLiabilityRevenueRecognized	73500000
CY2023	ions	Patent Expenses PatentExpenses	4300000
CY2022	ions	Patent Expenses PatentExpenses	4700000
CY2021	ions	Patent Expenses PatentExpenses	5300000
CY2023Q4	ions	Number Of Publicly Held Companies In Which Entity Has Equity Investment NumberOfPubliclyHeldCompaniesInWhichEntityHasEquityInvestment	3
CY2023Q4	ions	Number Of Privately Held Companies In Which Entity Has Equity Investment NumberOfPrivatelyHeldCompaniesInWhichEntityHasEquityInvestment	7
CY2023Q4	us-gaap	Debt Securities Available For Sale Amortized Cost Current DebtSecuritiesAvailableForSaleAmortizedCostCurrent	1316219000
CY2023Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Gain Before Tax Current DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent	415000
CY2023Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Loss Before Tax Current DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent	5238000
CY2023Q4	us-gaap	Available For Sale Securities Debt Securities Current AvailableForSaleSecuritiesDebtSecuritiesCurrent	1311396000
CY2023Q4	us-gaap	Debt Securities Available For Sale Amortized Cost Noncurrent DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent	651628000
CY2023Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Gain Before Tax Noncurrent DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent	3063000
CY2023Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Loss Before Tax Noncurrent DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent	1197000
CY2023Q4	us-gaap	Available For Sale Securities Debt Securities Noncurrent AvailableForSaleSecuritiesDebtSecuritiesNoncurrent	653494000
CY2023Q4	us-gaap	Available For Sale Debt Securities Amortized Cost Basis AvailableForSaleDebtSecuritiesAmortizedCostBasis	1967847000
CY2023Q4	us-gaap	Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax	3478000
CY2023Q4	us-gaap	Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax	6435000
CY2023Q4	us-gaap	Available For Sale Securities Debt Securities AvailableForSaleSecuritiesDebtSecurities	1964890000
CY2023Q4	us-gaap	Equity Securities Fv Ni Cost EquitySecuritiesFvNiCost	35012000
CY2023Q4	ions	Equity Securities Fv Ni Accumulated Gross Unrealized Gain EquitySecuritiesFvNiAccumulatedGrossUnrealizedGain	25237000
CY2023Q4	ions	Equity Securities Fv Ni Accumulated Gross Unrealized Loss EquitySecuritiesFvNiAccumulatedGrossUnrealizedLoss	10957000
CY2023Q4	us-gaap	Equity Securities Fv Ni EquitySecuritiesFvNi	49292000
CY2022Q4	us-gaap	Debt Securities Available For Sale Amortized Cost Current DebtSecuritiesAvailableForSaleAmortizedCostCurrent	1223522000
CY2022Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Gain Before Tax Current DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent	64000
CY2022Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Loss Before Tax Current DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent	12018000
CY2022Q4	us-gaap	Available For Sale Securities Debt Securities Current AvailableForSaleSecuritiesDebtSecuritiesCurrent	1211568000
CY2022Q4	us-gaap	Debt Securities Available For Sale Amortized Cost Noncurrent DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent	525314000
CY2022Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Gain Before Tax Noncurrent DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent	130000
CY2022Q4	ions	Debt Securities Available For Sale Accumulated Gross Unrealized Loss Before Tax Noncurrent DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent	15621000
CY2022Q4	us-gaap	Available For Sale Securities Debt Securities Noncurrent AvailableForSaleSecuritiesDebtSecuritiesNoncurrent	509823000
CY2022Q4	ions	Equity Securities Fv Ni Accumulated Gross Unrealized Loss EquitySecuritiesFvNiAccumulatedGrossUnrealizedLoss	1358000
CY2023Q4	us-gaap	Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months Accumulated Loss DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss	1847000
CY2023Q4	us-gaap	Operating Lease Liability OperatingLeaseLiability	178969000
CY2022Q4	us-gaap	Operating Lease Liability OperatingLeaseLiability	186156000
CY2023Q4	us-gaap	Loans Payable To Bank LoansPayableToBank	8859000
CY2022Q4	us-gaap	Loans Payable To Bank LoansPayableToBank	8998000
CY2023Q4	us-gaap	Other Liabilities OtherLiabilities	33714000
CY2022Q4	us-gaap	Other Liabilities OtherLiabilities	7295000
CY2023Q4	ions	Long Term Obligations LongTermObligations	1922943000
CY2022Q4	ions	Long Term Obligations LongTermObligations	1369195000
CY2023Q4	ions	Long Term Obligations Current LongTermObligationsCurrent	8831000
CY2022Q4	ions	Long Term Obligations Current LongTermObligationsCurrent	7535000
CY2023Q4	ions	Long Term Obligations Noncurrent LongTermObligationsNoncurrent	1914112000
CY2022	ions	Number Of Purchase And Sale Agreements Entered Into With Real Estate Investor NumberOfPurchaseAndSaleAgreementsEnteredIntoWithRealEstateInvestor	2
CY2023Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Next Twelve Months LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths	55298000
CY2023Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Year Two LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo	10657000
CY2023Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Year Three LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree	643157000
CY2023Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Year Four LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour	10509000
CY2023Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Year Five LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive	580277000
CY2023Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal After Year Five LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive	8462000
CY2023Q4	us-gaap	Long Term Debt LongTermDebt	1308360000
CY2023Q4	us-gaap	Long Term Debt Current LongTermDebtCurrent	157000
CY2023Q4	us-gaap	Interest Payable Current And Noncurrent InterestPayableCurrentAndNoncurrent	47138000
CY2023Q4	us-gaap	Deferred Finance Costs Net DeferredFinanceCostsNet	20061000
CY2023Q4	us-gaap	Long Term Debt Noncurrent LongTermDebtNoncurrent	1241004000
CY2023Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	171900000
CY2023Q4	us-gaap	Operating Lease Weighted Average Discount Rate Percent OperatingLeaseWeightedAverageDiscountRatePercent	0.069
CY2022	us-gaap	Operating Lease Payments OperatingLeasePayments	4000000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Two LesseeOperatingLeaseLiabilityPaymentsDueYearTwo	20645000
CY2023Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	170875000
CY2023	us-gaap	Operating Lease Expense OperatingLeaseExpense	23100000
CY2022	us-gaap	Operating Lease Expense OperatingLeaseExpense	8300000
CY2021	us-gaap	Operating Lease Expense OperatingLeaseExpense	3400000
CY2023	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	105809000
CY2022	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	100264000
CY2023	us-gaap	Income Loss From Continuing Operations Before Income Taxes Domestic IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic	-334707000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Domestic IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic	-258493000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Domestic IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic	-29966000
CY2023	us-gaap	Income Loss From Continuing Operations Before Income Taxes Foreign IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign	742000
CY2022	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	11737000
CY2023	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	32321000
CY2022	us-gaap	Income Tax Reconciliation State And Local Income Taxes IncomeTaxReconciliationStateAndLocalIncomeTaxes	-13622000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation State And Local Income Taxes EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes	-0.147
CY2023	us-gaap	Income Tax Reconciliation Foreign Income Tax Rate Differential IncomeTaxReconciliationForeignIncomeTaxRateDifferential	-22000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential	0
CY2022	us-gaap	Income Tax Reconciliation Foreign Income Tax Rate Differential IncomeTaxReconciliationForeignIncomeTaxRateDifferential	-49000
CY2021	us-gaap	Income Tax Reconciliation Foreign Income Tax Rate Differential IncomeTaxReconciliationForeignIncomeTaxRateDifferential	143000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential	-0.005
CY2023	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	175388000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance	-0.525
CY2022	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	104951000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance	-0.407
CY2021	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	2885000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance	-0.099
CY2023	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Loss On Debt Transactions Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLossOnDebtTransactionsAmount	0
CY2023	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Loss On Debt Transactions Percent EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLossOnDebtTransactionsPercent	0
CY2022	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Loss On Debt Transactions Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLossOnDebtTransactionsAmount	0
CY2022	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Loss On Debt Transactions Percent EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLossOnDebtTransactionsPercent	0
CY2021	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Loss On Debt Transactions Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLossOnDebtTransactionsAmount	262000
CY2021	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Loss On Debt Transactions Percent EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLossOnDebtTransactionsPercent	-0.009
CY2023	us-gaap	Income Tax Reconciliation Tax Credits IncomeTaxReconciliationTaxCredits	67131000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Tax Credits EffectiveIncomeTaxRateReconciliationTaxCredits	-0.201
CY2022	us-gaap	Income Tax Reconciliation Tax Credits IncomeTaxReconciliationTaxCredits	39729000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Tax Credits EffectiveIncomeTaxRateReconciliationTaxCredits	-0.154
CY2021	us-gaap	Income Tax Reconciliation Tax Credits IncomeTaxReconciliationTaxCredits	23198000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Tax Credits EffectiveIncomeTaxRateReconciliationTaxCredits	-0.796
CY2023	us-gaap	Income Tax Reconciliation Prior Year Income Taxes IncomeTaxReconciliationPriorYearIncomeTaxes	4000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Prior Year Income Taxes EffectiveIncomeTaxRateReconciliationPriorYearIncomeTaxes	0
CY2022	us-gaap	Income Tax Reconciliation Prior Year Income Taxes IncomeTaxReconciliationPriorYearIncomeTaxes	-20000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Prior Year Income Taxes EffectiveIncomeTaxRateReconciliationPriorYearIncomeTaxes	0
CY2021	us-gaap	Income Tax Reconciliation Prior Year Income Taxes IncomeTaxReconciliationPriorYearIncomeTaxes	-24000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Prior Year Income Taxes EffectiveIncomeTaxRateReconciliationPriorYearIncomeTaxes	0.001
CY2023	us-gaap	Income Tax Reconciliation Change In Enacted Tax Rate IncomeTaxReconciliationChangeInEnactedTaxRate	1023000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Change In Enacted Tax Rate EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate	-0.003
CY2022	us-gaap	Income Tax Reconciliation Change In Enacted Tax Rate IncomeTaxReconciliationChangeInEnactedTaxRate	-3091000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Change In Enacted Tax Rate EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate	0.012
CY2021	us-gaap	Income Tax Reconciliation Change In Enacted Tax Rate IncomeTaxReconciliationChangeInEnactedTaxRate	12838000
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Change In Enacted Tax Rate EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate	-0.44
CY2023	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Excess Compensation Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcessCompensationAmount	3814000
CY2023	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Excess Compensation Percent EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcessCompensationPercent	-0.011
CY2022	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Excess Compensation Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcessCompensationAmount	3023000
CY2021	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Excess Compensation Percent EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcessCompensationPercent	-0.174
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Nondeductible Expense Other EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther	-0.001
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Nondeductible Expense Other EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther	0
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Nondeductible Expense Other EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther	-0.003
CY2023	us-gaap	Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost	19546000
CY2022	us-gaap	Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost	14030000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost	-0.054
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost	-0.162
CY2023	us-gaap	Income Tax Reconciliation Other Adjustments IncomeTaxReconciliationOtherAdjustments	-405000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Other Adjustments EffectiveIncomeTaxRateReconciliationOtherAdjustments	0.001
CY2022	us-gaap	Income Tax Reconciliation Other Adjustments IncomeTaxReconciliationOtherAdjustments	364000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Other Adjustments EffectiveIncomeTaxRateReconciliationOtherAdjustments	-0.001
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Other Adjustments EffectiveIncomeTaxRateReconciliationOtherAdjustments	0.051
CY2023	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	32321000
CY2023	us-gaap	Effective Income Tax Rate Continuing Operations EffectiveIncomeTaxRateContinuingOperations	-0.097
CY2022	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	11737000
CY2022	us-gaap	Effective Income Tax Rate Continuing Operations EffectiveIncomeTaxRateContinuingOperations	-0.045
CY2021	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-551000
CY2023Q4	us-gaap	Deferred Tax Assets Operating Loss Carryforwards DeferredTaxAssetsOperatingLossCarryforwards	77964000
CY2022Q4	us-gaap	Deferred Tax Assets Operating Loss Carryforwards DeferredTaxAssetsOperatingLossCarryforwards	87802000
CY2023Q4	us-gaap	Deferred Tax Assets Tax Credit Carryforwards DeferredTaxAssetsTaxCreditCarryforwards	239962000
CY2022Q4	us-gaap	Deferred Tax Assets Tax Credit Carryforwards DeferredTaxAssetsTaxCreditCarryforwards	277436000
CY2023Q4	us-gaap	Deferred Tax Assets Deferred Income DeferredTaxAssetsDeferredIncome	71683000
CY2022Q4	us-gaap	Deferred Tax Assets Deferred Income DeferredTaxAssetsDeferredIncome	85700000
CY2023Q4	us-gaap	Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost	77468000
CY2022Q4	us-gaap	Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost	86983000
CY2023Q4	us-gaap	Deferred Tax Assets Goodwill And Intangible Assets DeferredTaxAssetsGoodwillAndIntangibleAssets	104380000
CY2022Q4	us-gaap	Deferred Tax Assets Goodwill And Intangible Assets DeferredTaxAssetsGoodwillAndIntangibleAssets	104649000
CY2023Q4	ions	Deferred Tax Assets Capitalized Research And Development Expenses DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses	238738000
CY2022Q4	ions	Deferred Tax Assets Capitalized Research And Development Expenses DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses	119635000
CY2023Q4	ions	Deferred Tax Assets Leasing Arrangements DeferredTaxAssetsLeasingArrangements	43718000
CY2022Q4	ions	Deferred Tax Assets Leasing Arrangements DeferredTaxAssetsLeasingArrangements	45612000
CY2023Q4	us-gaap	Deferred Tax Assets Other DeferredTaxAssetsOther	10343000
CY2022Q4	us-gaap	Deferred Tax Assets Other DeferredTaxAssetsOther	15813000
CY2023Q4	us-gaap	Deferred Tax Liabilities Leasing Arrangements DeferredTaxLiabilitiesLeasingArrangements	42007000
CY2022Q4	us-gaap	Deferred Tax Liabilities Leasing Arrangements DeferredTaxLiabilitiesLeasingArrangements	44504000
CY2022Q4	us-gaap	Deferred Tax Liabilities Other DeferredTaxLiabilitiesOther	313000
CY2022Q4	ions	Deferred Tax Assets Liabilities Net Before Valuation Allowance DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance	808722000
CY2021	us-gaap	Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions	263000
CY2023Q4	us-gaap	Decrease In Unrecognized Tax Benefits Is Reasonably Possible DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible	7600000
CY2023	us-gaap	Unrecognized Tax Benefits Income Tax Penalties And Interest Expense UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense	100000
CY2021	us-gaap	Unrecognized Tax Benefits Income Tax Penalties And Interest Expense UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense	500000
CY2023	us-gaap	Defined Contribution Plan Cost Recognized DefinedContributionPlanCostRecognized	7100000
CY2022	us-gaap	Defined Contribution Plan Cost Recognized DefinedContributionPlanCostRecognized	5600000
CY2021	us-gaap	Defined Contribution Plan Cost Recognized DefinedContributionPlanCostRecognized	5500000
CY2023Q4	us-gaap	Revenues Revenues	324505000
CY2022Q4	us-gaap	Revenues Revenues	151890000
CY2023Q4	us-gaap	Costs And Expenses CostsAndExpenses	330627000
CY2022Q4	us-gaap	Costs And Expenses CostsAndExpenses	359909000
CY2023Q4	us-gaap	Operating Income Loss OperatingIncomeLoss	-6122000
CY2022Q4	us-gaap	Operating Income Loss OperatingIncomeLoss	-208019000
CY2023Q4	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-0.06
CY2022Q4	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-0.37
CY2023Q4	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.06
CY2022Q4	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.37
CY2022Q4	us-gaap	Sale And Leaseback Transaction Gain Loss Net SaleAndLeasebackTransactionGainLossNet	150100000
CY2023	dei	Amendment Flag AmendmentFlag	false
CY2023	dei	Current Fiscal Year End Date CurrentFiscalYearEndDate	--12-31
CY2023	dei	Document Fiscal Year Focus DocumentFiscalYearFocus	2023
CY2023	dei	Document Fiscal Period Focus DocumentFiscalPeriodFocus	FY
CY2023	dei	Entity Central Index Key EntityCentralIndexKey	0000874015
CY2023Q4	ecd	Trd Arr Duration TrdArrDuration	P15M
CY2023	ions	Period After Billing When Payment Is Received PeriodAfterBillingWhenPaymentIsReceived	P3M
CY2023	us-gaap	Number Of Operating Segments NumberOfOperatingSegments	1
CY2023	dei	Auditor Firm AuditorFirmId	42
CY2023	dei	Document Type DocumentType	10-K
CY2023	dei	Document Annual Report DocumentAnnualReport	true
CY2023	dei	Document Period End Date DocumentPeriodEndDate	2023-12-31
CY2023	dei	Document Transition Report DocumentTransitionReport	false
CY2023	dei	Entity File Number EntityFileNumber	000-19125
CY2023	dei	Entity Registrant Name EntityRegistrantName	Ionis Pharmaceuticals, Inc
CY2023	dei	Entity Incorporation State Country Code EntityIncorporationStateCountryCode	DE
CY2023	dei	Entity Tax Identification Number EntityTaxIdentificationNumber	33-0336973
CY2023	dei	Entity Address Address Line1 EntityAddressAddressLine1	2855 Gazelle Court
CY2023	dei	Entity Address City Or Town EntityAddressCityOrTown	Carlsbad
CY2023	dei	Entity Address State Or Province EntityAddressStateOrProvince	CA
CY2023	dei	Entity Address Postal Zip Code EntityAddressPostalZipCode	92010
CY2023	dei	City Area Code CityAreaCode	760
CY2023	dei	Local Phone Number LocalPhoneNumber	931-9200
CY2023	dei	Security12b Title Security12bTitle	Common Stock, $.001 Par Value
CY2023	dei	Trading Symbol TradingSymbol	IONS
CY2023	dei	Security Exchange Name SecurityExchangeName	NASDAQ
CY2023	dei	Entity Well Known Seasoned Issuer EntityWellKnownSeasonedIssuer	Yes
CY2023	dei	Entity Voluntary Filers EntityVoluntaryFilers	No
CY2023	dei	Entity Current Reporting Status EntityCurrentReportingStatus	Yes
CY2023	dei	Entity Interactive Data Current EntityInteractiveDataCurrent	Yes
CY2023	dei	Entity Filer Category EntityFilerCategory	Large Accelerated Filer
CY2023	dei	Entity Small Business EntitySmallBusiness	false
CY2023	dei	Entity Emerging Growth Company EntityEmergingGrowthCompany	false
CY2023	dei	Icfr Auditor Attestation Flag IcfrAuditorAttestationFlag	true
CY2023	dei	Document Fin Stmt Error Correction Flag DocumentFinStmtErrorCorrectionFlag	false
CY2023	dei	Entity Shell Company EntityShellCompany	false
CY2023Q2	dei	Entity Public Float EntityPublicFloat	4243321410
CY2024Q1	dei	Entity Common Stock Shares Outstanding EntityCommonStockSharesOutstanding	145751797
CY2023Q4	ecd	Non Rule10b51 Arr Adopted Flag NonRule10b51ArrAdoptedFlag	false
CY2023Q4	ecd	Trd Arr Ind Name TrdArrIndName	Joseph Wender
CY2023Q4	ecd	Trd Arr Ind Title TrdArrIndTitle	Board Member
CY2023Q4	ecd	Trd Arr Adoption Date TrdArrAdoptionDate	November 30, 2023
CY2023Q4	ecd	Rule10b51 Arr Adopted Flag Rule10b51ArrAdoptedFlag	true
CY2023Q4	ecd	Trd Arr Securities Agg Avail Amt TrdArrSecuritiesAggAvailAmt	104079
CY2023	dei	Auditor Name AuditorName	Ernst & Young LLP
CY2023	dei	Auditor Location AuditorLocation	San Diego, California
CY2023Q4	us-gaap	Short Term Investments ShortTermInvestments	1931935000
CY2022Q4	us-gaap	Short Term Investments ShortTermInvestments	1710397000
CY2022Q4	us-gaap	Other Assets Current OtherAssetsCurrent	168254000
CY2022Q4	us-gaap	Assets Current AssetsCurrent	2202694000
CY2023Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	171896000
CY2022Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	181544000
CY2023Q4	us-gaap	Other Assets Noncurrent OtherAssetsNoncurrent	105280000
CY2023Q4	us-gaap	Convertible Debt Current ConvertibleDebtCurrent	44332000
CY2022Q4	us-gaap	Convertible Debt Current ConvertibleDebtCurrent	0
CY2023Q4	ions	Liability Related To Sale Of Future Royalties Net LiabilityRelatedToSaleOfFutureRoyaltiesNet	513736000
CY2022Q4	ions	Liability Related To Sale Of Future Royalties Net LiabilityRelatedToSaleOfFutureRoyaltiesNet	0
CY2023Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-32645000
CY2022Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-57480000
CY2022Q4	us-gaap	Retained Earnings Accumulated Deficit RetainedEarningsAccumulatedDeficit	-1429625000
CY2022	us-gaap	Costs And Expenses CostsAndExpenses	997558000
CY2022	us-gaap	Operating Income Loss OperatingIncomeLoss	-410191000
CY2021	us-gaap	Operating Income Loss OperatingIncomeLoss	-30186000
CY2023	ions	Interest Expense And Amortization Of Issuance Costs Related To Sale Of Future Royalties InterestExpenseAndAmortizationOfIssuanceCostsRelatedToSaleOfFutureRoyalties	68797000
CY2022	ions	Interest Expense And Amortization Of Issuance Costs Related To Sale Of Future Royalties InterestExpenseAndAmortizationOfIssuanceCostsRelatedToSaleOfFutureRoyalties	0
CY2021	ions	Interest Expense And Amortization Of Issuance Costs Related To Sale Of Future Royalties InterestExpenseAndAmortizationOfIssuanceCostsRelatedToSaleOfFutureRoyalties	0
CY2022	us-gaap	Gain Loss On Disposition Of Assets1 GainLossOnDispositionOfAssets1	149604000
CY2021	us-gaap	Gain Loss On Disposition Of Assets1 GainLossOnDispositionOfAssets1	0
CY2023	us-gaap	Net Income Loss NetIncomeLoss	-366286000
CY2022	us-gaap	Net Income Loss NetIncomeLoss	-269722000
CY2021	us-gaap	Net Income Loss NetIncomeLoss	-28597000
CY2023	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-2.56
CY2022	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	141848000
CY2021	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	141021000
CY2023	us-gaap	Net Income Loss NetIncomeLoss	-366286000
CY2022	us-gaap	Net Income Loss NetIncomeLoss	-269722000
CY2021	us-gaap	Net Income Loss NetIncomeLoss	-28597000
CY2023	us-gaap	Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent	24484000
CY2022	us-gaap	Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent	-24395000
CY2021	us-gaap	Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent	-11486000
CY2023	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-341451000
CY2022	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-294534000
CY2021	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-40194000
CY2020Q4	us-gaap	Stockholders Equity StockholdersEquity	743282000
CY2021	us-gaap	Net Income Loss NetIncomeLoss	-28597000
CY2021	us-gaap	Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent	-11486000
CY2021	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax	-111000
CY2021	us-gaap	Stock Issued During Period Value Share Based Compensation Gross StockIssuedDuringPeriodValueShareBasedCompensationGross	11564000
CY2021	us-gaap	Adjustments To Additional Paid In Capital Warrant Issued AdjustmentsToAdditionalPaidInCapitalWarrantIssued	89752000
CY2021	us-gaap	Adjustments To Additional Paid In Capital Other AdjustmentsToAdditionalPaidInCapitalOther	-136620000
CY2021	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	120678000
CY2021	us-gaap	Adjustments Related To Tax Withholding For Share Based Compensation AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation	16725000
CY2021Q4	us-gaap	Stockholders Equity StockholdersEquity	771737000
CY2022	us-gaap	Net Income Loss NetIncomeLoss	-269722000
CY2022	us-gaap	Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent	-24395000
CY2022	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax	-417000
CY2022	us-gaap	Stock Issued During Period Value Share Based Compensation Gross StockIssuedDuringPeriodValueShareBasedCompensationGross	6373000
CY2022	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	100264000
CY2022	us-gaap	Adjustments Related To Tax Withholding For Share Based Compensation AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation	10953000
CY2022Q4	us-gaap	Stockholders Equity StockholdersEquity	572887000
CY2023	us-gaap	Net Income Loss NetIncomeLoss	-366286000
CY2023	us-gaap	Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent	24484000
CY2023	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax	351000
CY2023	us-gaap	Stock Issued During Period Value Share Based Compensation Gross StockIssuedDuringPeriodValueShareBasedCompensationGross	49441000
CY2023	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	105809000
CY2023Q4	us-gaap	Stockholders Equity StockholdersEquity	386686000
CY2023	us-gaap	Net Income Loss NetIncomeLoss	-366286000
CY2022	us-gaap	Net Income Loss NetIncomeLoss	-269722000
CY2021	us-gaap	Net Income Loss NetIncomeLoss	-28597000
CY2023	us-gaap	Operating Lease Right Of Use Asset Amortization Expense OperatingLeaseRightOfUseAssetAmortizationExpense	9647000
CY2022	us-gaap	Operating Lease Right Of Use Asset Amortization Expense OperatingLeaseRightOfUseAssetAmortizationExpense	5362000
CY2021	us-gaap	Operating Lease Right Of Use Asset Amortization Expense OperatingLeaseRightOfUseAssetAmortizationExpense	1721000
CY2023	us-gaap	Amortization Of Intangible Assets AmortizationOfIntangibleAssets	2559000
CY2022	us-gaap	Amortization Of Intangible Assets AmortizationOfIntangibleAssets	2415000
CY2023	ions	Royalty Payments RoyaltyPayments	44628000
CY2022	ions	Royalty Payments RoyaltyPayments	0
CY2021	ions	Royalty Payments RoyaltyPayments	0
CY2023	ions	Interest Expense Related To Sale Of Future Royalties InterestExpenseRelatedToSaleOfFutureRoyalties	68238000
CY2022	ions	Interest Expense Related To Sale Of Future Royalties InterestExpenseRelatedToSaleOfFutureRoyalties	0
CY2021	ions	Interest Expense Related To Sale Of Future Royalties InterestExpenseRelatedToSaleOfFutureRoyalties	0
CY2022	us-gaap	Share Based Compensation ShareBasedCompensation	100264000
CY2023	us-gaap	Gain Loss On Disposition Of Assets GainLossOnDispositionOfAssets	-16649000
CY2022	us-gaap	Sale And Leaseback Transaction Gain Loss Net SaleAndLeasebackTransactionGainLossNet	150135000
CY2021	us-gaap	Sale And Leaseback Transaction Gain Loss Net SaleAndLeasebackTransactionGainLossNet	0
CY2022	us-gaap	Impairment Of Intangible Assets Finitelived ImpairmentOfIntangibleAssetsFinitelived	2030000
CY2023	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	6392000
CY2022	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	-2773000
CY2021	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	2841000
CY2023	us-gaap	Increase Decrease In Other Operating Assets IncreaseDecreaseInOtherOperatingAssets	29840000
CY2022	us-gaap	Increase Decrease In Other Operating Assets IncreaseDecreaseInOtherOperatingAssets	24682000
CY2023	us-gaap	Increase Decrease In Other Current Liabilities IncreaseDecreaseInOtherCurrentLiabilities	-5506000
CY2022	us-gaap	Increase Decrease In Other Current Liabilities IncreaseDecreaseInOtherCurrentLiabilities	46695000
CY2021	us-gaap	Increase Decrease In Other Current Liabilities IncreaseDecreaseInOtherCurrentLiabilities	-8381000
CY2022	us-gaap	Proceeds From Sale And Maturity Of Available For Sale Securities ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities	989152000
CY2021	us-gaap	Proceeds From Sale And Maturity Of Available For Sale Securities ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities	1344185000
CY2023	ions	Proceeds From Sale Of Future Royalties ProceedsFromSaleOfFutureRoyalties	500000000
CY2022	ions	Proceeds From Sale Of Future Royalties ProceedsFromSaleOfFutureRoyalties	0
CY2021	ions	Proceeds From Sale Of Future Royalties ProceedsFromSaleOfFutureRoyalties	0
CY2023	ions	Payments For Transaction Costs Related To Sale Of Future Royalties PaymentsForTransactionCostsRelatedToSaleOfFutureRoyalties	10434000
CY2022	ions	Payments For Transaction Costs Related To Sale Of Future Royalties PaymentsForTransactionCostsRelatedToSaleOfFutureRoyalties	29000
CY2021	ions	Payments For Transaction Costs Related To Sale Of Future Royalties PaymentsForTransactionCostsRelatedToSaleOfFutureRoyalties	0
CY2023	ions	Proceeds From Real Estate Transaction ProceedsFromRealEstateTransaction	32352000
CY2022	ions	Proceeds From Real Estate Transaction ProceedsFromRealEstateTransaction	0
CY2021	ions	Proceeds From Real Estate Transaction ProceedsFromRealEstateTransaction	0
CY2022	us-gaap	Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations	-418000
CY2021	us-gaap	Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations	-111000
CY2023	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect	122794000
CY2021Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	869191000
CY2023Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	399266000
CY2022Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	276472000
CY2023	us-gaap	Use Of Estimates UseOfEstimates	<div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Use of Estimates</div> <div><br/> </div> <div style="display:none;"><br/></div> <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">We prepare our consolidated financial statements in conformity with accounting principles generally accepted in the United States, or U.S., that require us to make estimates and assumptions that affect the amounts reported in our consolidated financial statements and accompanying notes. Actual results could differ from our estimates.</div>
CY2023	ions	Number Of Significant Customers NumberOfSignificantCustomers	1
CY2022	ions	Number Of Significant Customers NumberOfSignificantCustomers	1
CY2023	us-gaap	Concentration Risk Credit Risk ConcentrationRiskCreditRisk	<div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Concentration of Credit Risk</div> <div><br/> </div> <div style="display:none;"><br/></div> <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Financial instruments that potentially subject us to concentrations of credit risk consist primarily of cash equivalents, short-term investments and receivables. We place our cash equivalents and short-term investments with reputable financial institutions. We primarily invest our excess cash in commercial paper and debt instruments of the U.S. Treasury, financial institutions, corporations, and U.S. government agencies with strong credit ratings and an investment grade rating at or above A-1, P-1 or F-1 by Moody’s, Standard & Poor’s, or S&P, or Fitch, respectively. We have established guidelines relative to diversification and maturities that maintain safety and liquidity. We periodically review and modify these guidelines to maximize trends in yields and interest rates without compromising safety and liquidity.</div>
CY2023Q4	us-gaap	Inventory Net InventoryNet	28425000
CY2023Q4	us-gaap	Inventory Raw Materials InventoryRawMaterials	22794000
CY2022Q4	us-gaap	Inventory Raw Materials InventoryRawMaterials	19760000
CY2023Q4	us-gaap	Inventory Work In Process InventoryWorkInProcess	5477000
CY2022Q4	us-gaap	Inventory Work In Process InventoryWorkInProcess	2109000
CY2023Q4	us-gaap	Inventory Finished Goods InventoryFinishedGoods	154000
CY2022Q4	us-gaap	Inventory Finished Goods InventoryFinishedGoods	164000
CY2022Q4	us-gaap	Inventory Net InventoryNet	22033000
CY2023Q4	us-gaap	Accumulated Depreciation Depletion And Amortization Property Plant And Equipment AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment	96759000
CY2022Q4	us-gaap	Accumulated Depreciation Depletion And Amortization Property Plant And Equipment AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment	87716000
CY2023Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	71043000
CY2022Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	74294000
CY2023Q4	ions	Accrued Clinical Development Expenses AccruedClinicalDevelopmentExpenses	105967000
CY2022Q4	ions	Accrued Clinical Development Expenses AccruedClinicalDevelopmentExpenses	116460000
CY2023Q4	ions	Accrued In Licensing Fees Current AccruedInLicensingFeesCurrent	7454000
CY2022Q4	ions	Accrued In Licensing Fees Current AccruedInLicensingFeesCurrent	7945000
CY2023Q4	ions	Accrued Commercial Expenses Current AccruedCommercialExpensesCurrent	4875000
CY2022Q4	ions	Accrued Commercial Expenses Current AccruedCommercialExpensesCurrent	3498000
CY2023Q4	us-gaap	Other Accrued Liabilities Current OtherAccruedLiabilitiesCurrent	29598000
CY2022Q4	us-gaap	Other Accrued Liabilities Current OtherAccruedLiabilitiesCurrent	12198000
CY2023Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	147894000
CY2022Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	140101000
CY2023	us-gaap	Revenue From Contract With Customer Excluding Assessed Tax RevenueFromContractWithCustomerExcludingAssessedTax	787647000
CY2022	us-gaap	Revenue From Contract With Customer Excluding Assessed Tax RevenueFromContractWithCustomerExcludingAssessedTax	587367000
CY2021	us-gaap	Revenue From Contract With Customer Excluding Assessed Tax RevenueFromContractWithCustomerExcludingAssessedTax	810456000
CY2022Q4	us-gaap	Available For Sale Debt Securities Amortized Cost Basis AvailableForSaleDebtSecuritiesAmortizedCostBasis	1748836000
CY2022Q4	us-gaap	Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax	194000
CY2022Q4	us-gaap	Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax	27639000
CY2022Q4	us-gaap	Available For Sale Securities Debt Securities AvailableForSaleSecuritiesDebtSecurities	1721391000
CY2022Q4	us-gaap	Equity Securities Fv Ni Cost EquitySecuritiesFvNiCost	35012000
CY2022Q4	ions	Equity Securities Fv Ni Accumulated Gross Unrealized Gain EquitySecuritiesFvNiAccumulatedGrossUnrealizedGain	17257000
CY2022Q4	us-gaap	Equity Securities Fv Ni EquitySecuritiesFvNi	50911000
CY2023Q4	us-gaap	Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months Number Of Positions DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions	455
CY2023Q4	us-gaap	Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months	857398000
CY2023Q4	us-gaap	Debt Securities Available For Sale Continuous Unrealized Loss Position12 Months Or Longer DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger	331848000
CY2023Q4	us-gaap	Debt Securities Available For Sale Continuous Unrealized Loss Position12 Months Or Longer Accumulated Loss DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss	4588000
CY2023Q4	us-gaap	Debt Securities Available For Sale Unrealized Loss Position DebtSecuritiesAvailableForSaleUnrealizedLossPosition	1189246000
CY2023Q4	us-gaap	Debt Securities Available For Sale Unrealized Loss Position Accumulated Loss DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss	6435000
CY2023Q4	ions	Liability Related To Sale Of Future Royalties Net LiabilityRelatedToSaleOfFutureRoyaltiesNet	513736000
CY2022Q4	ions	Liability Related To Sale Of Future Royalties Net LiabilityRelatedToSaleOfFutureRoyaltiesNet	0
CY2023Q4	us-gaap	Operating Lease Liability OperatingLeaseLiability	179000000
CY2023Q4	us-gaap	Operating Lease Weighted Average Remaining Lease Term1 OperatingLeaseWeightedAverageRemainingLeaseTerm1	P13Y
CY2023	us-gaap	Operating Lease Payments OperatingLeasePayments	20100000
CY2021	us-gaap	Operating Lease Payments OperatingLeasePayments	3300000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due Next Twelve Months LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths	20398000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Three LesseeOperatingLeaseLiabilityPaymentsDueYearThree	20781000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Four LesseeOperatingLeaseLiabilityPaymentsDueYearFour	20800000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Five LesseeOperatingLeaseLiabilityPaymentsDueYearFive	20774000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due After Year Five LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive	176138000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Payments Due LesseeOperatingLeaseLiabilityPaymentsDue	279536000
CY2023Q4	us-gaap	Lessee Operating Lease Liability Undiscounted Excess Amount LesseeOperatingLeaseLiabilityUndiscountedExcessAmount	100567000
CY2023Q4	us-gaap	Operating Lease Liability Current OperatingLeaseLiabilityCurrent	8094000
CY2023Q1	ions	Upfront Royalty Payment Received UpfrontRoyaltyPaymentReceived	500000000
CY2023Q1	ions	Maximum Amount Of Payments Receivable For Additional Milestones MaximumAmountOfPaymentsReceivableForAdditionalMilestones	625000000
CY2023Q1	ions	Upfront Royalty Payment Received UpfrontRoyaltyPaymentReceived	500000000
CY2021	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	120678000
CY2023	us-gaap	Current Federal Tax Expense Benefit CurrentFederalTaxExpenseBenefit	35861000
CY2022	us-gaap	Current Federal Tax Expense Benefit CurrentFederalTaxExpenseBenefit	10522000
CY2021	us-gaap	Current Federal Tax Expense Benefit CurrentFederalTaxExpenseBenefit	-200000
CY2023	us-gaap	Current State And Local Tax Expense Benefit CurrentStateAndLocalTaxExpenseBenefit	-3687000
CY2022	us-gaap	Current State And Local Tax Expense Benefit CurrentStateAndLocalTaxExpenseBenefit	1129000
CY2021	us-gaap	Current State And Local Tax Expense Benefit CurrentStateAndLocalTaxExpenseBenefit	-690000
CY2023	us-gaap	Current Foreign Tax Expense Benefit CurrentForeignTaxExpenseBenefit	147000
CY2022	us-gaap	Current Foreign Tax Expense Benefit CurrentForeignTaxExpenseBenefit	86000
CY2021	us-gaap	Current Foreign Tax Expense Benefit CurrentForeignTaxExpenseBenefit	339000
CY2023	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	32321000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation State And Local Income Taxes EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes	0.053
CY2021	us-gaap	Income Tax Reconciliation State And Local Income Taxes IncomeTaxReconciliationStateAndLocalIncomeTaxes	4278000
CY2022	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Excess Compensation Percent EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcessCompensationPercent	-0.012
CY2021	ions	Effective Income Tax Rate Reconciliation Nondeductible Expense Excess Compensation Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExcessCompensationAmount	5085000
CY2023	us-gaap	Income Tax Reconciliation Nondeductible Expense Other IncomeTaxReconciliationNondeductibleExpenseOther	327000
CY2022	us-gaap	Income Tax Reconciliation Nondeductible Expense Other IncomeTaxReconciliationNondeductibleExpenseOther	57000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Fdii Amount EffectiveIncomeTaxRateReconciliationFdiiAmount	7493000
CY2023	us-gaap	Effective Income Tax Rate Reconciliation Fdii Percent EffectiveIncomeTaxRateReconciliationFdiiPercent	-0.022
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Fdii Amount EffectiveIncomeTaxRateReconciliationFdiiAmount	0
CY2022	us-gaap	Effective Income Tax Rate Reconciliation Fdii Percent EffectiveIncomeTaxRateReconciliationFdiiPercent	0
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Fdii Amount EffectiveIncomeTaxRateReconciliationFdiiAmount	0
CY2021	us-gaap	Effective Income Tax Rate Reconciliation Fdii Percent EffectiveIncomeTaxRateReconciliationFdiiPercent	0
CY2021	us-gaap	Income Tax Reconciliation Other Adjustments IncomeTaxReconciliationOtherAdjustments	-1503000
CY2021	us-gaap	Effective Income Tax Rate Continuing Operations EffectiveIncomeTaxRateContinuingOperations	0.019
CY2023Q4	ions	Deferred Tax Assets Sale Of Future Royalties DeferredTaxAssetsSaleOfFutureRoyalties	144608000
CY2022Q4	ions	Deferred Tax Assets Sale Of Future Royalties DeferredTaxAssetsSaleOfFutureRoyalties	0
CY2023Q4	us-gaap	Deferred Tax Liabilities Other DeferredTaxLiabilitiesOther	1910000
CY2023Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	977630000
CY2022Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	808722000
CY2023Q4	us-gaap	Deferred Tax Assets Liabilities Net DeferredTaxAssetsLiabilitiesNet	0
CY2022Q4	us-gaap	Deferred Tax Assets Liabilities Net DeferredTaxAssetsLiabilitiesNet	0
CY2023	us-gaap	Unrecognized Tax Benefits Reductions Resulting From Lapse Of Applicable Statute Of Limitations UnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations	14993000
CY2022	us-gaap	Unrecognized Tax Benefits Reductions Resulting From Lapse Of Applicable Statute Of Limitations UnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations	0
CY2021	us-gaap	Unrecognized Tax Benefits Reductions Resulting From Lapse Of Applicable Statute Of Limitations UnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations	0
CY2023Q4	us-gaap	Net Income Loss NetIncomeLoss	-9263000
CY2022Q4	us-gaap	Net Income Loss NetIncomeLoss	-52430000

Files In Submission

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2024 Q1 Form 10-K Financial Statement

#000087401524000116 Filed on February 21, 2024

Income Statement

Balance Sheet

Cashflow Statement

Facts In Submission

Files In Submission

$IONS IONIS PHARMACEUTICALS INC Stock $ions

2024 Q1 Form 10-K Financial Statement

#000087401524000116 Filed on February 21, 2024

Income Statement

Balance Sheet

Cashflow Statement

Facts In Submission

Files In Submission

$IONS
IONIS PHARMACEUTICALS INC Stock $ions