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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation | |||||
| Acquired in-process research and development | |||||
| Amortization of discount on marketable securities, net | |||||
| Depreciation and amortization | |||||
| Change in fair value of equity investments | |||||
| Non-cash collaboration royalty revenue | |||||
| Non-cash royalty revenue | |||||
| Non-cash interest expense on liabilities for sales of future royalties | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Inventory | |||||
| Prepaid expenses and other assets | |||||
| Other assets | |||||
| Accounts payable, accrued, and other liabilities | |||||
| Contract liabilities, net | |||||
| Deferred tax liabilities | |||||
| Net cash used in operating activities | |||||
| Investing activities: | |||||
| Purchase of property, plant, and equipment | |||||
| Acquisition, net of cash acquired | |||||
| Purchase of marketable securities | |||||
| Proceeds from sale of marketable securities | |||||
| Proceeds from sale of equity investments | |||||
| Proceeds from maturities of marketable securities | |||||
| Payments for intangible asset | |||||
| Other | |||||
| Net cash provided by (used in) investing activities | |||||
| Financing activities: | |||||
| Proceeds from the sale of future royalties, net | |||||
| Proceeds from the issuance of common stock and pre-funded warrants in connection with underwritten public offerings, net | |||||
| Proceeds from the issuance of common stock in connection with at-the-market offering, net of issuances costs | |||||
| Proceeds from the issuance of common stock in connection with at-the-market offering, net | |||||
| Proceeds from the issuance of common stock under equity plans, net | |||||
| Proceeds from issuance of equity from noncontrolling interest | |||||
| Other | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash | |||||
| Net increase (decrease) in cash, cash equivalents, and restricted cash | |||||
| Cash, cash equivalents, and restricted cash at beginning of year | |||||
| Cash, cash equivalents, and restricted cash at end of year | |||||
| Supplemental disclosures of non-cash information: | |||||
| Acquired lease liabilities arising from obtaining right-of-use assets and property, plant, and equipment | |||||
| Non-cash interest expense on liabilities for sales of future royalties capitalized during the year into ending property, plant and equipment | |||||
| Costs of intangible assets included in accounts payable, accrued and other liabilities | |||||
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