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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation expense | |||||
| Stock-based compensation | |||||
| Research and development license expense | |||||
| Change in fair value of warrant liability | |||||
| Issuance costs for pre-funded warrant liability | |||||
| Non-cash loss on debt extinguishment | |||||
| Non-cash change in fair value of term loan | |||||
| Debt issuance costs expensed under the fair value option | |||||
| Impairment of long-lived assets | |||||
| Non-cash lease expense | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other assets | |||||
| Accounts payable | |||||
| Accrued expenses and other liabilities | |||||
| Deferred revenue | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities | |||||
| Purchase of research and development license | |||||
| Purchase of property, plant and equipment | |||||
| Other | |||||
| Net cash used in investing activities | |||||
| Cash flows from financing activities | |||||
| Proceeds from issuance of common stock and pre-funded warrants from underwritten public offering, net of underwriting discounts and sales commissions and other offering costs | |||||
| Proceeds from issuance of common stock pursuant to at-the-market offering, net of sales commissions and other offering costs | |||||
| Prepayment of 2023 Trinity term loan | |||||
| Proceeds from 2025 Trinity term loan, net | |||||
| Proceeds from issuance of common stock upon exercise of warrants | |||||
| Debt issuance costs for term loan | |||||
| Repayment of SVB term loan | |||||
| Proceeds from Trinity term loan, net | |||||
| Proceeds from issuance of common stock and pre-funded warrants from private placement, net of placement agent commissions and other offering costs | |||||
| Proceeds from issuance of common stock from private placement | |||||
| Private Placement | |||||
| Total proceeds from issuance of common stock from private placement | |||||
| Payment of shelf registration costs | |||||
| Proceeds from common stock issuances under ESPP | |||||
| Proceeds from stock option exercises | |||||
| Other | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at the beginning of the period | |||||
| Cash, cash equivalents and restricted cash at the end of the period | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
| Supplemental disclosure of cash flow information: | |||||
| Cash paid for interest | |||||
| Supplemental disclosure of noncash investing and financing activities: | |||||
| Proceeds allocated to Success Fee liability | |||||
| Right-of-use assets obtained in exchange for lease liabilities | |||||
| Purchase of research and development license not yet paid | |||||
| Non-cash impact of exercise of liability classified warrants | |||||
| Allocation of proceeds to Success Fee liability | |||||
| Recognition of asset retirement obligation | |||||
| Issuance of warrants in connection with private placement | |||||
| Property, plant and equipment in accounts payable and accrued expenses | |||||
| Offering costs not yet paid | |||||
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