Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.
Reported portfolio value by quarter (37 quarters reported)
$116M in Q4 2015 → — now. Hover for any quarter.
As reported for the quarter ended December 31, 2024. Activity is the change in share count since the prior quarter's filing.
| Holding | % of portfolio | Activity | Shares | Value |
|---|---|---|---|---|
| 0 0 | NaN% | New | 0 | — |
What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.
quarter ended December 31, 2024 · filed February 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Revolution Medicines Inc | Exited | −4,279,464 | −$194M | — |
| Tyra Biosciences Inc | Exited | −6,448,359 | −$152M | — |
| Nuvalent Inc | Exited | −1,120,192 | −$115M | — |
| B Beigene Ltd | Exited | −500,000 | −$112M | — |
| Cytokinetics Inc | Exited | −2,100,000 | −$111M | — |
| Springworks Therapeutics Inc | Exited | −3,421,541 | −$110M | — |
| Merus N V | Exited | −1,900,000 | −$94.9M | — |
| Sarepta Therapeutics Inc | Exited | −650,000 | −$81.2M | — |
| Avidity Biosciences Inc | Exited | −1,727,388 | −$79.3M | — |
| Ideaya Biosciences Inc | Exited | −2,202,812 | −$69.8M | — |
Showing the 10 largest of 69 changes.
quarter ended September 30, 2024 · filed November 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Instil Bio Inc | New | +355,500 | +$23.9M | 1.2% |
| Kymera Therapeutics Inc | New | +450,000 | +$21.3M | 1.0% |
| Nurix Therapeutics Inc | New | +563,067 | +$12.7M | 0.6% |
| Fate Therapeutics Inc | Trimmed | −3,255,000 | −$11.4M | 0.9% |
| UN Uniqure Nv | New | +2,225,000 | +$11M | 0.5% |
| Apogee Therapeutics Inc | New | +179,000 | +$10.5M | 0.5% |
| Allogene Therapeutics Inc | Exited | −3,850,000 | −$8.97M | — |
| Nkarta Inc | Trimmed | −1,577,744 | −$7.13M | 0.9% |
| Poseida Therapeutics | Trimmed | −2,475,000 | −$7.08M | 0.3% |
| Terns Pharmaceuticals Inc | New | +752,000 | +$6.27M | 0.3% |
Showing the 10 largest of 23 changes.
quarter ended June 30, 2024 · filed August 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Atara Biotherapeutics Inc | Trimmed | −3,984,000 | −$33.9M | 0.1% |
| Viking Therapeutics Inc | Exited | −300,000 | −$24.6M | — |
| ET Eliem Therapeutics Inc | New | +2,603,190 | +$18.5M | 1.0% |
| Iteos Therapeutics Inc | Added | +1,142,857 | +$17M | 2.3% |
| Replimune Group Inc | New | +1,536,341 | +$13.8M | 0.7% |
| Cullinan Therapeutics Inc | New | +657,895 | +$11.5M | 0.6% |
| Spyre Therapeutics Inc | Added | +446,480 | +$10.5M | 0.9% |
| Century Therapeutics Inc | Added | +3,151,603 | +$8.04M | 0.7% |
| Olema Pharmaceuticals Inc | New | +650,000 | +$7.03M | 0.4% |
| DS Direxion Shs ETF Tr | Exited | −350,000 | −$2.55M | — |
Showing the 10 largest of 12 changes.
quarter ended March 31, 2024 · filed May 15, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Mirati Therapeutics Inc | Exited | −3,201,440 | −$188M | — |
| Immunogen Inc | Exited | −2,961,000 | −$87.8M | — |
| Karuna Therapeutics Inc | Exited | −250,000 | −$79.1M | — |
| Fate Therapeutics Inc | Added | +7,715,910 | +$56.6M | 3.0% |
| Nkarta Inc | Added | +4,167,350 | +$45M | 3.0% |
| Viking Therapeutics Inc | New | +300,000 | +$24.6M | 1.2% |
| Argenx Se | Trimmed | −60,000 | −$23.6M | 1.9% |
| Kura Oncology Inc | New | +1,000,000 | +$21.3M | 1.1% |
| Allogene Therapeutics Inc | New | +3,850,000 | +$17.2M | 0.8% |
| Avidity Biosciences Inc | Added | +606,061 | +$15.5M | 2.2% |
Showing the 10 largest of 30 changes.
quarter ended December 31, 2023 · filed February 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Amylyx Pharmaceuticals Inc | Exited | −2,084,000 | −$38.2M | — |
| SS SPDR Ser Tr | Exited | −500,000 | −$36.5M | — |
| Ventyx Biosciences Inc | Exited | −850,000 | −$29.5M | — |
| Argenx Se | Added | +75,000 | +$28.5M | 3.0% |
| Amicus Therapeutics Inc | Exited | −2,325,000 | −$28.3M | — |
| Exelixis Inc | Exited | −1,150,000 | −$25.1M | — |
| Arvinas Inc | New | +608,614 | +$25.1M | 1.2% |
| Sage Therapeutics Inc | Exited | −1,094,000 | −$22.5M | — |
| Viking Therapeutics Inc | Exited | −2,000,000 | −$22.1M | — |
| Pmv Pharmaceuticals Inc | Exited | −3,163,795 | −$19.4M | — |
Showing the 10 largest of 40 changes.
quarter ended September 30, 2023 · filed November 14, 2023
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| RP Reata Pharmaceuticals Inc | Exited | −1,430,004 | −$146M | — |
| Mirati Therapeutics Inc | Added | +1,201,440 | +$52.3M | 7.4% |
| 89bio Inc | Exited | −2,100,000 | −$39.8M | — |
| SS SPDR Ser Tr | New | +500,000 | +$36.5M | 1.9% |
| IB Iveric Bio Inc | Exited | −825,000 | −$32.5M | — |
| Immunovant Inc | New | +750,000 | +$28.8M | 1.5% |
| Prothena Corp PLC | Added | +325,000 | +$15.7M | 1.6% |
| Acumen Pharmaceuticals Inc | New | +2,206,983 | +$9.16M | 0.5% |
| Cabaletta Bio Inc | Exited | −540,000 | −$6.97M | — |
| Disc Medicine Inc | Exited | −130,000 | −$5.77M | — |
Showing the 10 largest of 32 changes.
quarter ended June 30, 2023 · filed August 14, 2023
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| PB Prometheus Biosciences Inc | Exited | −1,897,500 | −$204M | — |
| Immunogen Inc | New | +2,961,000 | +$55.9M | 2.6% |
| Karuna Therapeutics Inc | New | +250,000 | +$54.2M | 2.5% |
| Legend Biotech Corp | New | +600,000 | +$41.4M | 1.9% |
| Seagen Inc | Exited | −200,000 | −$40.5M | — |
| Akero Therapeutics Inc | Added | +845,238 | +$39.5M | 3.6% |
| Argenx Se | New | +75,000 | +$29.2M | 1.4% |
| Madrigal Pharmaceuticals Inc | New | +100,000 | +$23.1M | 1.1% |
| BH Bellus Health Inc New | Exited | −3,200,000 | −$23M | — |
| RP Reata Pharmaceuticals Inc | Added | +200,000 | +$20.4M | 6.8% |
Showing the 10 largest of 24 changes.
quarter ended March 31, 2023 · filed May 15, 2023
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Sarepta Therapeutics Inc | New | +775,000 | +$107M | 5.2% |
| Seagen Inc | New | +200,000 | +$40.5M | 2.0% |
| Geron Corp | Exited | −8,100,000 | −$19.6M | — |
| Enliven Therapeutics Inc | New | +710,644 | +$15.6M | 0.8% |
| Revolution Medicines Inc | Added | +700,000 | +$15.2M | 5.0% |
| Iovance Biotherapeutics Inc | Added | +2,200,000 | +$13.4M | 1.1% |
| Kalvista Pharmaceuticals Inc | New | +1,650,000 | +$13M | 0.6% |
| 89bio Inc | Added | +700,000 | +$10.7M | 1.6% |
| Viking Therapeutics Inc | Added | +500,000 | +$8.33M | 1.6% |
| MH Morphic Hldg Inc | New | +200,000 | +$7.53M | 0.4% |
Showing the 10 largest of 18 changes.
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