2014 Q1 Form 10-K Financial Statement
#000110465914015019 Filed on March 03, 2014
Income Statement
| Concept | 2014 Q1 | 2013 Q4 | 2013 Q3 |
|---|---|---|---|
| Revenue | $28.20M | $42.25M | $23.59M |
| YoY Change | -34.96% | 112.59% | 103.3% |
| Cost Of Revenue | |||
| YoY Change | |||
| Gross Profit | |||
| YoY Change | |||
| Gross Profit Margin | |||
| Selling, General & Admin | $4.400M | $4.700M | $3.400M |
| YoY Change | 29.41% | 46.88% | 9.68% |
| % of Gross Profit | |||
| Research & Development | $53.40M | $57.40M | $45.00M |
| YoY Change | 39.38% | 26.4% | |
| % of Gross Profit | |||
| Depreciation & Amortization | $2.300M | ||
| YoY Change | -11.54% | ||
| % of Gross Profit | |||
| Operating Expenses | $57.80M | $62.11M | $49.09M |
| YoY Change | 38.49% | 35.04% | 23.82% |
| Operating Profit | -$19.86M | -$25.51M | |
| YoY Change | -23.97% | -9.06% | |
| Interest Expense | -$3.900M | -$3.900M | $4.867M |
| YoY Change | -181.33% | -125.83% | -18.02% |
| % of Operating Profit | |||
| Other Income/Expense, Net | |||
| YoY Change | |||
| Pretax Income | -$33.60M | -$23.80M | -$29.76M |
| YoY Change | 1835.48% | -90.18% | -22.38% |
| Income Tax | -$2.300M | $500.0K | -$5.200M |
| % Of Pretax Income | |||
| Net Earnings | -$31.30M | -$24.30M | -$24.60M |
| YoY Change | 1741.18% | -89.62% | -34.57% |
| Net Earnings / Revenue | -110.99% | -57.52% | -104.3% |
| Basic Earnings Per Share | -$0.27 | ||
| Diluted Earnings Per Share | -$0.27 | -$209.1K | -$213.4K |
| COMMON SHARES | |||
| Basic Shares Outstanding | 117.3M shares | 116.1M shares | 115.3M shares |
| Diluted Shares Outstanding | 115.3M shares |
Balance Sheet
| Concept | 2014 Q1 | 2013 Q4 | 2013 Q3 |
|---|---|---|---|
| SHORT-TERM ASSETS | |||
| Cash & Short-Term Investments | $694.9M | $656.8M | $670.9M |
| YoY Change | 86.85% | 75.4% | 95.27% |
| Cash & Equivalents | $161.8M | $160.0M | $256.4M |
| Short-Term Investments | $533.1M | $496.8M | $414.5M |
| Other Short-Term Assets | $9.800M | $7.518M | $7.372M |
| YoY Change | 21.38% | -13.85% | -5.49% |
| Inventory | $7.500M | $8.000M | $7.400M |
| Prepaid Expenses | |||
| Receivables | $9.800M | $11.10M | $12.60M |
| Other Receivables | $0.00 | $0.00 | $0.00 |
| Total Short-Term Assets | $722.1M | $735.5M | $763.3M |
| YoY Change | 67.22% | 73.7% | 111.1% |
| LONG-TERM ASSETS | |||
| Property, Plant & Equipment | $86.60M | $86.20M | $87.27M |
| YoY Change | -3.45% | -5.36% | -5.75% |
| Goodwill | |||
| YoY Change | |||
| Intangibles | |||
| YoY Change | |||
| Long-Term Investments | |||
| YoY Change | |||
| Other Assets | $5.400M | $5.400M | $5.500M |
| YoY Change | -6.9% | -8.47% | -9.84% |
| Total Long-Term Assets | $112.5M | $111.6M | $118.6M |
| YoY Change | -7.13% | -8.67% | -4.43% |
| TOTAL ASSETS | |||
| Total Short-Term Assets | $722.1M | $735.5M | $763.3M |
| Total Long-Term Assets | $112.5M | $111.6M | $118.6M |
| Total Assets | $834.6M | $847.2M | $881.9M |
| YoY Change | 50.93% | 55.25% | 81.58% |
| SHORT-TERM LIABILITIES | |||
| YoY Change | |||
| Accounts Payable | $9.900M | $11.01M | $8.781M |
| YoY Change | 83.84% | 7.52% | 67.07% |
| Accrued Expenses | $32.20M | $22.09M | $22.28M |
| YoY Change | 81.33% | 43.45% | 87.25% |
| Deferred Revenue | |||
| YoY Change | |||
| Short-Term Debt | $0.00 | $0.00 | $0.00 |
| YoY Change | |||
| Long-Term Debt Due | $4.300M | $4.400M | $4.600M |
| YoY Change | -4.44% | -10.2% | -11.54% |
| Total Short-Term Liabilities | $100.8M | $97.81M | $103.3M |
| YoY Change | 43.4% | 31.61% | 100.15% |
| LONG-TERM LIABILITIES | |||
| Long-Term Debt | $228.9M | $228.2M | $226.2M |
| YoY Change | 2.74% | 2.84% | 2.21% |
| Other Long-Term Liabilities | $130.8M | $142.8M | $151.0M |
| YoY Change | 122.45% | 114.09% | 255.29% |
| Total Long-Term Liabilities | $359.7M | $371.0M | $377.2M |
| YoY Change | 27.73% | 28.55% | 42.99% |
| TOTAL LIABILITIES | |||
| Total Short-Term Liabilities | $100.8M | $97.81M | $103.3M |
| Total Long-Term Liabilities | $359.7M | $371.0M | $377.2M |
| Total Liabilities | $460.5M | $468.8M | $480.5M |
| YoY Change | 30.86% | 29.17% | 52.33% |
| SHAREHOLDERS EQUITY | |||
| Retained Earnings | -$967.6M | -$943.3M | |
| YoY Change | 6.69% | 4.31% | |
| Common Stock | $1.325B | $1.316B | |
| YoY Change | 22.99% | 22.54% | |
| Preferred Stock | |||
| YoY Change | |||
| Treasury Stock (at cost) | |||
| YoY Change | |||
| Treasury Stock Shares | |||
| Shareholders Equity | $374.1M | $378.4M | $401.4M |
| YoY Change | |||
| Total Liabilities & Shareholders Equity | $834.6M | $847.2M | $881.9M |
| YoY Change | 50.93% | 55.25% | 81.58% |
Cashflow Statement
| Concept | 2014 Q1 | 2013 Q4 | 2013 Q3 |
|---|---|---|---|
| OPERATING ACTIVITIES | |||
| Net Income | -$31.30M | -$24.30M | -$24.60M |
| YoY Change | 1741.18% | -89.62% | -34.57% |
| Depreciation, Depletion And Amortization | $2.300M | ||
| YoY Change | -11.54% | ||
| Cash From Operating Activities | -$32.30M | -$14.50M | $65.80M |
| YoY Change | 204.72% | -140.17% | -364.26% |
| INVESTING ACTIVITIES | |||
| Capital Expenditures | -$1.400M | -$500.0K | -$500.0K |
| YoY Change | -730.63% | 0.0% | 400.0% |
| Acquisitions | |||
| YoY Change | |||
| Other Investing Activities | $26.20M | -$84.90M | -$122.7M |
| YoY Change | -273.51% | -1643.64% | 1079.81% |
| Cash From Investing Activities | $24.80M | -$85.20M | -$123.4M |
| YoY Change | -262.09% | -1804.0% | 1064.15% |
| FINANCING ACTIVITIES | |||
| Cash Dividend Paid | |||
| YoY Change | |||
| Common Stock Issuance & Retirement, Net | |||
| YoY Change | |||
| Debt Paid & Issued, Net | |||
| YoY Change | |||
| Cash From Financing Activities | 9.300M | 3.300M | 17.40M |
| YoY Change | 2.2% | -375.0% | -49.42% |
| NET CHANGE | |||
| Cash From Operating Activities | -32.30M | -14.50M | 65.80M |
| Cash From Investing Activities | 24.80M | -85.20M | -123.4M |
| Cash From Financing Activities | 9.300M | 3.300M | 17.40M |
| Net Change In Cash | 1.800M | -96.40M | -40.20M |
| YoY Change | -110.71% | -341.6% | 3554.55% |
| FREE CASH FLOW | |||
| Cash From Operating Activities | -$32.30M | -$14.50M | $65.80M |
| Capital Expenditures | -$1.400M | -$500.0K | -$500.0K |
| Free Cash Flow | -$30.90M | -$14.00M | $66.30M |
| YoY Change | 185.53% | -138.25% | -367.34% |
Facts In Submission
| Frame | Concept Type | Concept / XBRL Key | Value | Unit |
|---|---|---|---|---|
| CY2012 | us-gaap |
Interest Paid
InterestPaid
|
5770000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Other Employee Related Liabilities
IncreaseDecreaseInOtherEmployeeRelatedLiabilities
|
4290000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Deferred Liabilities
IncreaseDecreaseInDeferredLiabilities
|
217000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Accrued Liabilities
IncreaseDecreaseInAccruedLiabilities
|
6691000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Deferred Revenue
IncreaseDecreaseInDeferredRevenue
|
88344000 | USD |
| CY2013 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
425554000 | USD |
| CY2013 | us-gaap |
Proceeds From Sale And Maturity Of Available For Sale Securities
ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
|
172762000 | USD |
| CY2013Q4 | us-gaap |
Liabilities
Liabilities
|
468766000 | USD |
| CY2012 | us-gaap |
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent
|
13250000 | USD |
| CY2011 | us-gaap |
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent
|
-1719000 | USD |
| CY2011Q2 | us-gaap |
Class Of Warrant Or Right Outstanding
ClassOfWarrantOrRightOutstanding
|
0 | shares |
| CY2013 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
1552000 | USD |
| CY2013 | isis |
Payments To Acquire Licenses And Other Assets
PaymentsToAcquireLicensesAndOtherAssets
|
3810000 | USD |
| CY2013 | isis |
Proceeds From The Sale Of Strategic Investments
ProceedsFromTheSaleOfStrategicInvestments
|
2428000 | USD |
| CY2013 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
62958000 | USD |
| CY2013 | isis |
Proceeds From Equipment Financing Arrangement
ProceedsFromEquipmentFinancingArrangement
|
2513000 | USD |
| CY2013 | us-gaap |
Repayments Of Long Term Debt And Capital Securities
RepaymentsOfLongTermDebtAndCapitalSecurities
|
11039000 | USD |
| CY2013 | us-gaap |
Interest Paid
InterestPaid
|
6000000 | USD |
| CY2013 | us-gaap |
Income Taxes Paid Net
IncomeTaxesPaidNet
|
2000 | USD |
| CY2013 | isis |
Noncash Capital And Patent Expenditures
NoncashCapitalAndPatentExpenditures
|
704000 | USD |
| CY2010Q4 | us-gaap |
Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
|
949000 | USD |
| CY2011Q4 | us-gaap |
Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
|
-770000 | USD |
| CY2012 | us-gaap |
Other Comprehensive Income Loss Before Reclassifications Before Tax
OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax
|
13250000 | USD |
| CY2011 | us-gaap |
Other Comprehensive Income Loss Before Reclassifications Before Tax
OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax
|
-1719000 | USD |
| CY2013 | us-gaap |
Prior Period Reclassification Adjustment Description
PriorPeriodReclassificationAdjustmentDescription
|
<div style="font-size:10.0pt;font-family:Times New Roman;"> <p style="MARGIN: 0in 0in 0pt;"><b><font style="FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold;" size="2">Reclassifications</font></b></p> <p style="MARGIN: 0in 0in 0pt;"> </p> <p style="TEXT-INDENT: 0.5in; MARGIN: 0in 0in 0pt;"><font style="FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt;" size="2">We have reclassified certain prior period amounts to conform to the current period presentation.  Certain amounts previously reported as research and development revenue have been reclassified to licensing and royalty revenue to conform to the current period presentation.</font></p> </div> | |
| CY2013Q4 | us-gaap |
Inventory Raw Materials Net Of Reserves
InventoryRawMaterialsNetOfReserves
|
8033000 | USD |
| CY2012Q4 | us-gaap |
Inventory Raw Materials Net Of Reserves
InventoryRawMaterialsNetOfReserves
|
6121000 | USD |
| CY2013 | us-gaap |
Research And Development Expense
ResearchAndDevelopmentExpense
|
173700000 | USD |
| CY2012 | us-gaap |
Research And Development Expense
ResearchAndDevelopmentExpense
|
154600000 | USD |
| CY2012Q4 | us-gaap |
Land
Land
|
10198000 | USD |
| CY2013Q4 | us-gaap |
Land
Land
|
10198000 | USD |
| CY2012Q4 | isis |
Property Plant And Equipment Gross Excluding Land
PropertyPlantAndEquipmentGrossExcludingLand
|
135351000 | USD |
| CY2013Q4 | isis |
Property Plant And Equipment Gross Excluding Land
PropertyPlantAndEquipmentGrossExcludingLand
|
136431000 | USD |
| CY2012Q4 | us-gaap |
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
|
54465000 | USD |
| CY2013Q4 | us-gaap |
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
|
60431000 | USD |
| CY2012Q4 | isis |
Property Plant And Equipment Net Excluding Land
PropertyPlantAndEquipmentNetExcludingLand
|
80886000 | USD |
| CY2013Q4 | isis |
Property Plant And Equipment Net Excluding Land
PropertyPlantAndEquipmentNetExcludingLand
|
76000000 | USD |
| CY2013Q4 | us-gaap |
Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
|
86198000 | USD |
| CY2012Q4 | us-gaap |
Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
|
91084000 | USD |
| CY2012 | us-gaap |
Impairment Of Long Lived Assets Held For Use
ImpairmentOfLongLivedAssetsHeldForUse
|
825000 | USD |
| CY2011 | us-gaap |
Impairment Of Long Lived Assets Held For Use
ImpairmentOfLongLivedAssetsHeldForUse
|
1900000 | USD |
| CY2013 | us-gaap |
Impairment Of Long Lived Assets Held For Use
ImpairmentOfLongLivedAssetsHeldForUse
|
6400000 | USD |
| CY2012 | isis |
Variable Interest Entity Not Primary Beneficiary Number Of Entities
VariableInterestEntityNotPrimaryBeneficiaryNumberOfEntities
|
6 | item |
| CY2013 | isis |
Variable Interest Entity Not Primary Beneficiary Number Of Entities
VariableInterestEntityNotPrimaryBeneficiaryNumberOfEntities
|
5 | item |
| CY2013Q4 | us-gaap |
Variable Interest Entity Nonconsolidated Carrying Amount Assets
VariableInterestEntityNonconsolidatedCarryingAmountAssets
|
53400000 | USD |
| CY2013Q4 | us-gaap |
Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
|
21080000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Loss Before Reclassifications Before Tax
OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax
|
10253000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Loss Reclassification Adjustment From Aoci For Sale Of Securities Net Of Tax
OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax
|
1653000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent
|
8600000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Loss Available For Sale Securities Before Reclassification Adjustments Tax
OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax
|
5900000 | USD |
| CY2012Q4 | us-gaap |
Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
|
12480000 | USD |
| CY2013 | us-gaap |
Use Of Estimates
UseOfEstimates
|
<div style="font-size:10.0pt;font-family:Times New Roman;"> <p style="MARGIN: 0in 0in 0pt;"><b><font style="FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold;" size="2">Use of estimates</font></b></p> <p style="MARGIN: 0in 0in 0pt;"> </p> <p style="TEXT-INDENT: 0.5in; MARGIN: 0in 0in 0pt;"><font style="FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt;" size="2">The preparation of consolidated financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates.</font></p> </div> | |
| CY2012 | us-gaap |
Other Comprehensive Income Loss Available For Sale Securities Before Reclassification Adjustments Tax
OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax
|
9100000 | USD |
| CY2013Q4 | isis |
Fair Value Assets Transfer Between Level1 And Level2 Amount
FairValueAssetsTransferBetweenLevel1AndLevel2Amount
|
0 | USD |
| CY2012Q4 | isis |
Fair Value Assets Transfer Between Level1 And Level2 Amount
FairValueAssetsTransferBetweenLevel1AndLevel2Amount
|
0 | USD |
| CY2013 | us-gaap |
Concentration Risk Credit Risk
ConcentrationRiskCreditRisk
|
<div style="font-size:10.0pt;font-family:Times New Roman;"> <p style="MARGIN: 0in 0in 0pt;"><b><font style="FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold;" size="2">Concentration of credit risk</font></b></p> <p style="MARGIN: 0in 0in 0pt;"> </p> <p style="TEXT-INDENT: 0.5in; MARGIN: 0in 0in 0pt;"><font style="FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt;" size="2">Financial instruments that potentially subject us to concentrations of credit risk consist primarily of cash equivalents, short-term investments and receivables. We place our cash equivalents and short-term investments with reputable financial institutions. We primarily invest our excess cash in commercial paper and debt instruments of the U.S. Treasury, financial institutions, corporations, and U.S. government agencies with strong credit ratings and an investment grade rating at or above A-1, P-1 or F-1 by Moody’s, Standard & Poor’s (S&P) or Fitch, respectively.  We have established guidelines relative to diversification and maturities that maintain safety and liquidity. We periodically review and modify these guidelines to maximize trends in yields and interest rates without compromising safety and liquidity.</font></p> </div> | |
| CY2012Q4 | us-gaap |
Cost Method Investments Fair Value Disclosure
CostMethodInvestmentsFairValueDisclosure
|
625000 | USD |
| CY2012Q4 | isis |
Available For Sale Securities Gross Unrealized Gain Accumulated In Investments
AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments
|
22581000 | USD |
| CY2012Q4 | isis |
Available For Sale Securities Gross Unrealized Loss Accumulated In Investments
AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments
|
185000 | USD |
| CY2012Q4 | isis |
Investments Other Than Temporary Impairment Loss Accumulated In Investments
InvestmentsOtherThanTemporaryImpairmentLossAccumulatedInInvestments
|
880000 | USD |
| CY2012Q4 | us-gaap |
Investments Fair Value Disclosure
InvestmentsFairValueDisclosure
|
293085000 | USD |
| CY2013Q4 | isis |
Available For Sale Securities Gross Unrealized Gain Accumulated In Investments
AvailableForSaleSecuritiesGrossUnrealizedGainAccumulatedInInvestments
|
37535000 | USD |
| CY2013Q4 | isis |
Investments Other Than Temporary Impairment Loss Accumulated In Investments
InvestmentsOtherThanTemporaryImpairmentLossAccumulatedInInvestments
|
880000 | USD |
| CY2013Q4 | us-gaap |
Investments Fair Value Disclosure
InvestmentsFairValueDisclosure
|
563909000 | USD |
| CY2013Q4 | us-gaap |
Availableforsale Securities In Unrealized Loss Positions Qualitative Disclosure Number Of Positions1
AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureNumberOfPositions1
|
163 | security |
| CY2013Q4 | isis |
Available For Sale Securities Debt Maturities Within Two Years Percentage
AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage
|
0.78 | pure |
| CY2013Q4 | isis |
Number Of Privately Held Companies In Which Entity Has Equity Investment
NumberOfPrivatelyHeldCompaniesInWhichEntityHasEquityInvestment
|
3 | entity |
| CY2013Q4 | isis |
Number Of Publicly Held Companies In Which Entity Has Equity Investment
NumberOfPubliclyHeldCompaniesInWhichEntityHasEquityInvestment
|
3 | entity |
| CY2012 | us-gaap |
Gain Loss On Investments
GainLossOnInvestments
|
1465000 | USD |
| CY2013 | us-gaap |
Gain Loss On Investments
GainLossOnInvestments
|
2378000 | USD |
| CY2013 | isis |
Research And Development Revenue Under Collaborative Agreements
ResearchAndDevelopmentRevenueUnderCollaborativeAgreements
|
144194000 | USD |
| CY2013Q4 | isis |
Available For Sale Securities Gross Unrealized Loss Accumulated In Investments
AvailableForSaleSecuritiesGrossUnrealizedLossAccumulatedInInvestments
|
619000 | USD |
| CY2012Q4 | us-gaap |
Cost Method Investments
CostMethodInvestments
|
625000 | USD |
| CY2013Q4 | isis |
Available For Sale Securities Debt Maturities Within One Year Percentage
AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage
|
0.34 | pure |
| CY2013Q4 | isis |
Available For Sale Securities Debt Maturities After One Through Two Years Percentage
AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage
|
0.44 | pure |
| CY2013Q4 | isis |
Available For Sale Securities Debt Maturities After Two Through Three Years Percentage
AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeYearsPercentage
|
0.22 | pure |
| CY2013Q4 | isis |
Available For Sale Securities Debt Maturities Total Percentage
AvailableForSaleSecuritiesDebtMaturitiesTotalPercentage
|
1.00 | pure |
| CY2013Q4 | us-gaap |
Available For Sale Securities Continuous Unrealized Loss Position Less Than Twelve Months Fair Value
AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue
|
269870000 | USD |
| CY2013Q4 | isis |
Available For Sale Securities Continuous Unrealized Loss Position Less Than12 Months Aggregate Losses Accumulated In Investments
AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLossesAccumulatedInInvestments
|
607000 | USD |
| CY2012 | us-gaap |
Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
|
8571000 | USD |
| CY2011 | us-gaap |
Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
|
9845000 | USD |
| CY2013 | us-gaap |
Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
|
11418000 | USD |
| CY2006Q2 | us-gaap |
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
|
4250000 | shares |
| CY2006Q2 | us-gaap |
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights
ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights
|
8.93 | |
| CY2011 | isis |
Income Tax Reconciliation Deferred Tax
IncomeTaxReconciliationDeferredTax
|
-4236000 | USD |
| CY2013 | isis |
Income Tax Reconciliation Deferred Tax
IncomeTaxReconciliationDeferredTax
|
8023000 | USD |
| CY2012 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax
|
9111000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax
|
5914000 | USD |
| CY2011 | us-gaap |
Current State And Local Tax Expense Benefit
CurrentStateAndLocalTaxExpenseBenefit
|
11000 | USD |
| CY2012 | us-gaap |
Current State And Local Tax Expense Benefit
CurrentStateAndLocalTaxExpenseBenefit
|
2000 | USD |
| CY2013 | us-gaap |
Current State And Local Tax Expense Benefit
CurrentStateAndLocalTaxExpenseBenefit
|
2000 | USD |
| CY2013 | us-gaap |
Current Income Tax Expense Benefit
CurrentIncomeTaxExpenseBenefit
|
2000 | USD |
| CY2012 | us-gaap |
Current Income Tax Expense Benefit
CurrentIncomeTaxExpenseBenefit
|
2000 | USD |
| CY2011 | us-gaap |
Current Income Tax Expense Benefit
CurrentIncomeTaxExpenseBenefit
|
11000 | USD |
| CY2012 | us-gaap |
Deferred Federal Income Tax Expense Benefit
DeferredFederalIncomeTaxExpenseBenefit
|
-7827000 | USD |
| CY2013 | us-gaap |
Deferred Federal Income Tax Expense Benefit
DeferredFederalIncomeTaxExpenseBenefit
|
-5082000 | USD |
| CY2013 | us-gaap |
Deferred State And Local Income Tax Expense Benefit
DeferredStateAndLocalIncomeTaxExpenseBenefit
|
-834000 | USD |
| CY2012 | us-gaap |
Deferred State And Local Income Tax Expense Benefit
DeferredStateAndLocalIncomeTaxExpenseBenefit
|
-1284000 | USD |
| CY2013 | isis |
Deferred Income Tax Expense Benefit Unrealized Gains On Securities
DeferredIncomeTaxExpenseBenefitUnrealizedGainsOnSecurities
|
-5914000 | USD |
| CY2012 | isis |
Deferred Income Tax Expense Benefit Unrealized Gains On Securities
DeferredIncomeTaxExpenseBenefitUnrealizedGainsOnSecurities
|
-9111000 | USD |
| CY2013 | us-gaap |
Deferred Income Tax Expense Benefit
DeferredIncomeTaxExpenseBenefit
|
-5916000 | USD |
| CY2012 | us-gaap |
Deferred Income Tax Expense Benefit
DeferredIncomeTaxExpenseBenefit
|
-9111000 | USD |
| CY2013 | us-gaap |
Income Tax Expense Benefit Intraperiod Tax Allocation
IncomeTaxExpenseBenefitIntraperiodTaxAllocation
|
-5914000 | USD |
| CY2012 | us-gaap |
Income Tax Expense Benefit Intraperiod Tax Allocation
IncomeTaxExpenseBenefitIntraperiodTaxAllocation
|
-9109000 | USD |
| CY2011 | us-gaap |
Income Tax Expense Benefit Intraperiod Tax Allocation
IncomeTaxExpenseBenefitIntraperiodTaxAllocation
|
11000 | USD |
| CY2012 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
|
-74587000 | USD |
| CY2011 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
|
-84790000 | USD |
| CY2013 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
|
-66558000 | USD |
| CY2012 | us-gaap |
Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
|
-26105000 | USD |
| CY2011 | us-gaap |
Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
|
-29677000 | USD |
| CY2013 | us-gaap |
Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
|
-23295000 | USD |
| CY2013 | us-gaap |
Income Tax Reconciliation State And Local Income Taxes
IncomeTaxReconciliationStateAndLocalIncomeTaxes
|
-3823000 | USD |
| CY2012 | us-gaap |
Income Tax Reconciliation State And Local Income Taxes
IncomeTaxReconciliationStateAndLocalIncomeTaxes
|
-4284000 | USD |
| CY2011 | us-gaap |
Income Tax Reconciliation State And Local Income Taxes
IncomeTaxReconciliationStateAndLocalIncomeTaxes
|
-4870000 | USD |
| CY2013 | us-gaap |
Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
28850000 | USD |
| CY2012 | us-gaap |
Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
25269000 | USD |
| CY2011 | us-gaap |
Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
41136000 | USD |
| CY2012 | isis |
Income Tax Reconciliation Gain Loss On Sale Of Previously Unissued Stock By Subsidiary Or Equity Investee Nonoperating Income
IncomeTaxReconciliationGainLossOnSaleOfPreviouslyUnissuedStockBySubsidiaryOrEquityInvesteeNonoperatingIncome
|
-6353000 | USD |
| CY2012 | us-gaap |
Income Tax Reconciliation Tax Credits
IncomeTaxReconciliationTaxCredits
|
-806000 | USD |
| CY2011 | us-gaap |
Income Tax Reconciliation Tax Credits
IncomeTaxReconciliationTaxCredits
|
4202000 | USD |
| CY2013 | us-gaap |
Income Tax Reconciliation Tax Credits
IncomeTaxReconciliationTaxCredits
|
15839000 | USD |
| CY2011 | us-gaap |
Income Tax Reconciliation Minority Interest Income Expense
IncomeTaxReconciliationMinorityInterestIncomeExpense
|
-1448000 | USD |
| CY2012 | isis |
Income Tax Reconciliation Deferred Tax
IncomeTaxReconciliationDeferredTax
|
839000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Gross
DeferredTaxAssetsGross
|
367764000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Other
DeferredTaxAssetsOther
|
7107000 | USD |
| CY2012Q4 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.03 | |
| CY2012 | us-gaap |
Income Tax Reconciliation Other Adjustments
IncomeTaxReconciliationOtherAdjustments
|
719000 | USD |
| CY2011 | us-gaap |
Income Tax Reconciliation Other Adjustments
IncomeTaxReconciliationOtherAdjustments
|
412000 | USD |
| CY2013 | us-gaap |
Income Tax Reconciliation Other Adjustments
IncomeTaxReconciliationOtherAdjustments
|
170000 | USD |
| CY2011 | us-gaap |
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
|
0.350 | pure |
| CY2012 | us-gaap |
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
|
0.350 | pure |
| CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
|
0.350 | pure |
| CY2012 | us-gaap |
Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
|
0.057 | pure |
| CY2011 | us-gaap |
Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
|
0.057 | pure |
| CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
|
0.057 | pure |
| CY2011 | us-gaap |
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
-0.485 | pure |
| CY2012 | us-gaap |
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
-0.339 | pure |
| CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
-0.433 | pure |
| CY2012 | isis |
Effective Income Tax Rate Reconciliation Gain Loss On Sale Of Previously Unissued Stock By Subsidiary Or Equity Investee Nonoperating Income
EffectiveIncomeTaxRateReconciliationGainLossOnSaleOfPreviouslyUnissuedStockBySubsidiaryOrEquityInvesteeNonoperatingIncome
|
0.085 | pure |
| CY2011 | us-gaap |
Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
|
-0.050 | pure |
| CY2012 | us-gaap |
Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
|
0.011 | pure |
| CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
|
-0.238 | pure |
| CY2011 | us-gaap |
Effective Income Tax Rate Reconciliation Minority Interest Income Expense
EffectiveIncomeTaxRateReconciliationMinorityInterestIncomeExpense
|
0.017 | pure |
| CY2011 | isis |
Effective Income Tax Rate Reconciliation Deferred Tax
EffectiveIncomeTaxRateReconciliationDeferredTax
|
0.050 | pure |
| CY2012 | isis |
Effective Income Tax Rate Reconciliation Deferred Tax
EffectiveIncomeTaxRateReconciliationDeferredTax
|
-0.011 | pure |
| CY2013 | isis |
Effective Income Tax Rate Reconciliation Deferred Tax
EffectiveIncomeTaxRateReconciliationDeferredTax
|
-0.121 | pure |
| CY2011 | us-gaap |
Effective Income Tax Rate Reconciliation Other Adjustments
EffectiveIncomeTaxRateReconciliationOtherAdjustments
|
-0.005 | pure |
| CY2012 | us-gaap |
Effective Income Tax Rate Reconciliation Other Adjustments
EffectiveIncomeTaxRateReconciliationOtherAdjustments
|
-0.009 | pure |
| CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Other Adjustments
EffectiveIncomeTaxRateReconciliationOtherAdjustments
|
-0.002 | pure |
| CY2011 | us-gaap |
Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
|
0.000 | pure |
| CY2012 | us-gaap |
Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
|
0.122 | pure |
| CY2013 | us-gaap |
Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
|
0.089 | pure |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
|
244539000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
|
46928000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets In Process Research And Development
DeferredTaxAssetsInProcessResearchAndDevelopment
|
22223000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Deferred Income
DeferredTaxAssetsDeferredIncome
|
7285000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Restructuring Charges
DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsRestructuringCharges
|
3605000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Other
DeferredTaxAssetsOther
|
18931000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Gross
DeferredTaxAssetsGross
|
343511000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Liabilities Financing Arrangements
DeferredTaxLiabilitiesFinancingArrangements
|
23322000 | USD |
| CY2012Q4 | isis |
Deferred Tax Liabilities Property Plant And Equipment And Goodwill And Intangible Assets
DeferredTaxLiabilitiesPropertyPlantAndEquipmentAndGoodwillAndIntangibleAssets
|
6784000 | USD |
| CY2012Q4 | isis |
Deferred Tax Assets Liabilities Before Valuation Allowance
DeferredTaxAssetsLiabilitiesBeforeValuationAllowance
|
313405000 | USD |
| CY2012Q4 | us-gaap |
Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
|
313405000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
|
260462000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
|
65600000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets In Process Research And Development
DeferredTaxAssetsInProcessResearchAndDevelopment
|
2736000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Deferred Income
DeferredTaxAssetsDeferredIncome
|
28555000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Restructuring Charges
DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsRestructuringCharges
|
3304000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Liabilities Financing Arrangements
DeferredTaxLiabilitiesFinancingArrangements
|
20895000 | USD |
| CY2013Q4 | isis |
Deferred Tax Liabilities Property Plant And Equipment And Goodwill And Intangible Assets
DeferredTaxLiabilitiesPropertyPlantAndEquipmentAndGoodwillAndIntangibleAssets
|
4614000 | USD |
| CY2013Q4 | isis |
Deferred Tax Assets Liabilities Before Valuation Allowance
DeferredTaxAssetsLiabilitiesBeforeValuationAllowance
|
342255000 | USD |
| CY2013Q4 | us-gaap |
Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
|
342255000 | USD |
| CY2013 | isis |
Adjustments To Additional Paid In Capital Tax Effect From Share Based Compensation Expected
AdjustmentsToAdditionalPaidInCapitalTaxEffectFromShareBasedCompensationExpected
|
27800000 | USD |
| CY2011Q4 | us-gaap |
Unrecognized Tax Benefits
UnrecognizedTaxBenefits
|
9834000 | USD |
| CY2012Q4 | us-gaap |
Unrecognized Tax Benefits
UnrecognizedTaxBenefits
|
10872000 | USD |
| CY2010Q4 | us-gaap |
Unrecognized Tax Benefits
UnrecognizedTaxBenefits
|
8968000 | USD |
| CY2013Q4 | us-gaap |
Unrecognized Tax Benefits
UnrecognizedTaxBenefits
|
23964000 | USD |
| CY2012 | us-gaap |
Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions
UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions
|
174000 | USD |
| CY2011 | us-gaap |
Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions
UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions
|
97000 | USD |
| CY2012 | us-gaap |
Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions
|
791000 | USD |
| CY2013 | us-gaap |
Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions
|
9821000 | USD |
| CY2012 | us-gaap |
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
|
421000 | USD |
| CY2011 | us-gaap |
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
|
963000 | USD |
| CY2013 | us-gaap |
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
|
3271000 | USD |
| CY2013 | isis |
Defined Contribution Plan Employee Contribution Limit By Plan Participants Under Fifty Years Age
DefinedContributionPlanEmployeeContributionLimitByPlanParticipantsUnderFiftyYearsAge
|
17500 | USD |
| CY2013 | isis |
Defined Contribution Plan Employee Contribution Limit By Plan Participants Over Fifty Years Age
DefinedContributionPlanEmployeeContributionLimitByPlanParticipantsOverFiftyYearsAge
|
23000 | USD |
| CY2012 | us-gaap |
Defined Contribution Plan Cost Recognized
DefinedContributionPlanCostRecognized
|
529000 | USD |
| CY2011 | us-gaap |
Defined Contribution Plan Cost Recognized
DefinedContributionPlanCostRecognized
|
487000 | USD |
| CY2013 | us-gaap |
Defined Contribution Plan Cost Recognized
DefinedContributionPlanCostRecognized
|
574000 | USD |
| CY2012Q1 | us-gaap |
Revenues
Revenues
|
23235000 | USD |
| CY2012Q2 | us-gaap |
Revenues
Revenues
|
47340000 | USD |
| CY2012Q3 | us-gaap |
Revenues
Revenues
|
11601000 | USD |
| CY2012Q4 | us-gaap |
Revenues
Revenues
|
19873000 | USD |
| CY2012Q1 | us-gaap |
Operating Expenses
OperatingExpenses
|
41690000 | USD |
| CY2012Q2 | us-gaap |
Operating Expenses
OperatingExpenses
|
43644000 | USD |
| CY2012Q3 | us-gaap |
Operating Expenses
OperatingExpenses
|
39647000 | USD |
| CY2012Q4 | us-gaap |
Operating Expenses
OperatingExpenses
|
45992000 | USD |
| CY2012Q1 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-18455000 | USD |
| CY2012Q2 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
3696000 | USD |
| CY2012Q3 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-28046000 | USD |
| CY2012Q4 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-26119000 | USD |
| CY2012Q1 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-23995000 | USD |
| CY2012Q2 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-1207000 | USD |
| CY2012Q3 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-37639000 | USD |
| CY2012Q4 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-2637000 | USD |
| CY2013Q1 | us-gaap |
Revenues
Revenues
|
43360000 | USD |
| CY2013Q2 | us-gaap |
Revenues
Revenues
|
38092000 | USD |
| CY2013Q3 | us-gaap |
Revenues
Revenues
|
23585000 | USD |
| CY2013Q4 | us-gaap |
Revenues
Revenues
|
42248000 | USD |
| CY2013Q1 | us-gaap |
Operating Expenses
OperatingExpenses
|
41735000 | USD |
| CY2011 | isis |
Amortization Of Patents
AmortizationOfPatents
|
1938000 | USD |
| CY2012 | isis |
Amortization Of Licenses
AmortizationOfLicenses
|
2457000 | USD |
| CY2013 | dei |
Entity Well Known Seasoned Issuer
EntityWellKnownSeasonedIssuer
|
Yes | |
| CY2013 | dei |
Entity Voluntary Filers
EntityVoluntaryFilers
|
No | |
| CY2013 | dei |
Entity Current Reporting Status
EntityCurrentReportingStatus
|
Yes | |
| CY2013 | dei |
Entity Filer Category
EntityFilerCategory
|
Large Accelerated Filer | |
| CY2013Q2 | dei |
Entity Public Float
EntityPublicFloat
|
2572530925 | USD |
| CY2012Q4 | us-gaap |
Liabilities Current
LiabilitiesCurrent
|
74322000 | USD |
| CY2013Q2 | us-gaap |
Operating Expenses
OperatingExpenses
|
46020000 | USD |
| CY2013Q3 | us-gaap |
Operating Expenses
OperatingExpenses
|
49090000 | USD |
| CY2013Q4 | us-gaap |
Operating Expenses
OperatingExpenses
|
62106000 | USD |
| CY2013Q1 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
1625000 | USD |
| CY2013Q2 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-7928000 | USD |
| CY2013Q3 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-25505000 | USD |
| CY2013Q4 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-19858000 | USD |
| CY2013Q1 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-1672000 | USD |
| CY2013Q2 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-10126000 | USD |
| CY2013Q3 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-24570000 | USD |
| CY2013Q4 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-24276000 | USD |
| CY2013 | dei |
Entity Registrant Name
EntityRegistrantName
|
ISIS PHARMACEUTICALS INC | |
| CY2013 | dei |
Entity Central Index Key
EntityCentralIndexKey
|
0000874015 | |
| CY2013 | dei |
Document Type
DocumentType
|
10-K | |
| CY2013 | dei |
Document Period End Date
DocumentPeriodEndDate
|
2013-12-31 | |
| CY2013 | dei |
Amendment Flag
AmendmentFlag
|
false | |
| CY2013 | dei |
Current Fiscal Year End Date
CurrentFiscalYearEndDate
|
--12-31 | |
| CY2014Q1 | dei |
Entity Common Stock Shares Outstanding
EntityCommonStockSharesOutstanding
|
117270225 | shares |
| CY2013 | dei |
Document Fiscal Year Focus
DocumentFiscalYearFocus
|
2013 | |
| CY2013 | dei |
Document Fiscal Period Focus
DocumentFiscalPeriodFocus
|
FY | |
| CY2012Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
124482000 | USD |
| CY2012Q4 | us-gaap |
Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
|
249964000 | USD |
| CY2012Q4 | us-gaap |
Receivables Long Term Contracts Or Programs
ReceivablesLongTermContractsOrPrograms
|
522000 | USD |
| CY2012Q4 | isis |
Significant Equity Investment
SignificantEquityInvestment
|
33622000 | USD |
| CY2012Q4 | us-gaap |
Other Assets Current
OtherAssetsCurrent
|
8727000 | USD |
| CY2012Q4 | us-gaap |
Assets Current
AssetsCurrent
|
423438000 | USD |
| CY2012Q4 | isis |
Licenses Net
LicensesNet
|
6579000 | USD |
| CY2012Q4 | isis |
Patents Net
PatentsNet
|
18646000 | USD |
| CY2012Q4 | isis |
Deposits And Other Assets Noncurrent
DepositsAndOtherAssetsNoncurrent
|
5939000 | USD |
| CY2012Q4 | us-gaap |
Assets
Assets
|
545686000 | USD |
| CY2012Q4 | us-gaap |
Accounts Payable Current
AccountsPayableCurrent
|
10239000 | USD |
| CY2012Q4 | us-gaap |
Employee Related Liabilities Current
EmployeeRelatedLiabilitiesCurrent
|
7878000 | USD |
| CY2012Q4 | us-gaap |
Accrued Liabilities Current
AccruedLiabilitiesCurrent
|
15401000 | USD |
| CY2012Q4 | us-gaap |
Long Term Debt And Capital Lease Obligations Current
LongTermDebtAndCapitalLeaseObligationsCurrent
|
4879000 | USD |
| CY2012Q4 | us-gaap |
Deferred Revenue Current
DeferredRevenueCurrent
|
35925000 | USD |
| CY2012Q4 | isis |
Long Term Financing Obligation
LongTermFinancingObligation
|
70550000 | USD |
| CY2012Q4 | us-gaap |
Deferred Revenue Noncurrent
DeferredRevenueNoncurrent
|
66656000 | USD |
| CY2012Q4 | us-gaap |
Convertible Debt Noncurrent
ConvertibleDebtNoncurrent
|
143990000 | USD |
| CY2012Q4 | isis |
Capital Lease And Other Long Term Borrowings Non Current
CapitalLeaseAndOtherLongTermBorrowingsNonCurrent
|
7402000 | USD |
| CY2012Q4 | us-gaap |
Liabilities
Liabilities
|
362920000 | USD |
| CY2012Q4 | us-gaap |
Common Stock Value
CommonStockValue
|
102000 | USD |
| CY2012Q4 | us-gaap |
Additional Paid In Capital Common Stock
AdditionalPaidInCapitalCommonStock
|
1077150000 | USD |
| CY2012Q4 | us-gaap |
Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
|
-906966000 | USD |
| CY2012Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
182766000 | USD |
| CY2012Q4 | us-gaap |
Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
|
545686000 | USD |
| CY2013Q4 | us-gaap |
Assets
Assets
|
847156000 | USD |
| CY2013Q4 | us-gaap |
Liabilities Current
LiabilitiesCurrent
|
97812000 | USD |
| CY2013 | us-gaap |
Revenues
Revenues
|
147285000 | USD |
| CY2012 | us-gaap |
Net Cash Provided By Used In Continuing Operations
NetCashProvidedByUsedInContinuingOperations
|
59005000 | USD |
| CY2012 | us-gaap |
Income Loss From Equity Method Investments
IncomeLossFromEquityMethodInvestments
|
-1406000 | USD |
| CY2012 | us-gaap |
Investment Income Net
InvestmentIncomeNet
|
1844000 | USD |
| CY2012 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-68924000 | USD |
| CY2011 | isis |
Amortization Of Licenses
AmortizationOfLicenses
|
3252000 | USD |
| CY2013Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
378390000 | USD |
| CY2013Q4 | us-gaap |
Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
|
847156000 | USD |
| CY2013Q4 | us-gaap |
Assets Current
AssetsCurrent
|
735510000 | USD |
| CY2013Q4 | us-gaap |
Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
|
0.001 | |
| CY2012Q4 | us-gaap |
Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
|
0.001 | |
| CY2013Q4 | us-gaap |
Common Stock Shares Authorized
CommonStockSharesAuthorized
|
200000000 | shares |
| CY2012Q4 | us-gaap |
Common Stock Shares Authorized
CommonStockSharesAuthorized
|
200000000 | shares |
| CY2013Q4 | us-gaap |
Common Stock Shares Issued
CommonStockSharesIssued
|
116471371 | shares |
| CY2013Q4 | us-gaap |
Common Stock Shares Outstanding
CommonStockSharesOutstanding
|
116471371 | shares |
| CY2012Q4 | us-gaap |
Common Stock Shares Issued
CommonStockSharesIssued
|
101481134 | shares |
| CY2012Q4 | us-gaap |
Common Stock Shares Outstanding
CommonStockSharesOutstanding
|
101481134 | shares |
| CY2012 | isis |
Research And Development Revenue Under Collaborative Agreements
ResearchAndDevelopmentRevenueUnderCollaborativeAgreements
|
96415000 | USD |
| CY2012 | isis |
Licensing And Royalty Revenue
LicensingAndRoyaltyRevenue
|
5634000 | USD |
| CY2012 | us-gaap |
Revenues
Revenues
|
102049000 | USD |
| CY2012 | isis |
Research Development And Patent Expense
ResearchDevelopmentAndPatentExpense
|
158458000 | USD |
| CY2012 | us-gaap |
General And Administrative Expense
GeneralAndAdministrativeExpense
|
12515000 | USD |
| CY2012 | us-gaap |
Operating Expenses
OperatingExpenses
|
170973000 | USD |
| CY2012 | us-gaap |
Interest Expense
InterestExpense
|
21152000 | USD |
| CY2012 | us-gaap |
Gain Loss On Sale Of Previously Unissued Stock By Subsidiary Or Equity Investee Nonoperating Income
GainLossOnSaleOfPreviouslyUnissuedStockBySubsidiaryOrEquityInvesteeNonoperatingIncome
|
18356000 | USD |
| CY2012 | us-gaap |
Gains Losses On Extinguishment Of Debt
GainsLossesOnExtinguishmentOfDebt
|
-4770000 | USD |
| CY2012 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-65478000 | USD |
| CY2012 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.65 | |
| CY2012 | us-gaap |
Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
|
100576000 | shares |
| CY2012 | us-gaap |
Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
|
100576000 | shares |
| CY2011 | isis |
Research And Development Revenue Under Collaborative Agreements
ResearchAndDevelopmentRevenueUnderCollaborativeAgreements
|
96190000 | USD |
| CY2011 | isis |
Licensing And Royalty Revenue
LicensingAndRoyaltyRevenue
|
2896000 | USD |
| CY2011 | us-gaap |
Revenues
Revenues
|
99086000 | USD |
| CY2011 | isis |
Research Development And Patent Expense
ResearchDevelopmentAndPatentExpense
|
157397000 | USD |
| CY2011 | us-gaap |
General And Administrative Expense
GeneralAndAdministrativeExpense
|
12789000 | USD |
| CY2011 | us-gaap |
Operating Expenses
OperatingExpenses
|
170186000 | USD |
| CY2011 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-71100000 | USD |
| CY2011 | us-gaap |
Income Loss From Equity Method Investments
IncomeLossFromEquityMethodInvestments
|
-3554000 | USD |
| CY2011 | us-gaap |
Investment Income Net
InvestmentIncomeNet
|
2414000 | USD |
| CY2011 | us-gaap |
Interest Expense
InterestExpense
|
16732000 | USD |
| CY2011 | us-gaap |
Gain Loss On Investments
GainLossOnInvestments
|
4182000 | USD |
| CY2011 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-84801000 | USD |
| CY2011 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.85 | |
| CY2011 | us-gaap |
Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
|
99656000 | shares |
| CY2011 | us-gaap |
Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
|
99656000 | shares |
| CY2013 | us-gaap |
Operating Expenses
OperatingExpenses
|
198951000 | USD |
| CY2013 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-51666000 | USD |
| CY2013 | us-gaap |
Net Income Loss Available To Common Stockholders Basic
NetIncomeLossAvailableToCommonStockholdersBasic
|
-60644000 | USD |
| CY2012 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
13250000 | USD |
| CY2012 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-52228000 | USD |
| CY2011 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
-1719000 | USD |
| CY2011 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-86520000 | USD |
| CY2013 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-52044000 | USD |
| CY2012 | us-gaap |
Profit Loss
ProfitLoss
|
-65478000 | USD |
| CY2011 | us-gaap |
Profit Loss
ProfitLoss
|
-84801000 | USD |
| CY2012 | us-gaap |
Depreciation
Depreciation
|
7074000 | USD |
| CY2011 | us-gaap |
Depreciation
Depreciation
|
6594000 | USD |
| CY2012 | isis |
Amortization Of Patents
AmortizationOfPatents
|
1224000 | USD |
| CY2012 | us-gaap |
Net Cash Provided By Used In Investing Activities Continuing Operations
NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
|
17999000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Other Employee Related Liabilities
IncreaseDecreaseInOtherEmployeeRelatedLiabilities
|
-1305000 | USD |
| CY2012 | isis |
Proceeds From The Sale Of Strategic Investments
ProceedsFromTheSaleOfStrategicInvestments
|
2177000 | USD |
| CY2011 | isis |
Proceeds From The Sale Of Strategic Investments
ProceedsFromTheSaleOfStrategicInvestments
|
4445000 | USD |
| CY2012 | us-gaap |
Investment Income Net Amortization Of Discount And Premium
InvestmentIncomeNetAmortizationOfDiscountAndPremium
|
-4193000 | USD |
| CY2011 | us-gaap |
Investment Income Net Amortization Of Discount And Premium
InvestmentIncomeNetAmortizationOfDiscountAndPremium
|
-5410000 | USD |
| CY2012 | us-gaap |
Amortization Of Financing Costs
AmortizationOfFinancingCosts
|
619000 | USD |
| CY2011 | us-gaap |
Amortization Of Financing Costs
AmortizationOfFinancingCosts
|
507000 | USD |
| CY2012 | isis |
Amortization Of Debt Discount Premium One
AmortizationOfDebtDiscountPremiumOne
|
6169000 | USD |
| CY2011 | isis |
Amortization Of Debt Discount Premium One
AmortizationOfDebtDiscountPremiumOne
|
8553000 | USD |
| CY2012 | isis |
Amortization Of Debt Discount Premium Two
AmortizationOfDebtDiscountPremiumTwo
|
2268000 | USD |
| CY2012 | isis |
Amortization Of Long Term Financing Liability For Leased Facility
AmortizationOfLongTermFinancingLiabilityForLeasedFacility
|
6503000 | USD |
| CY2011 | isis |
Amortization Of Long Term Financing Liability For Leased Facility
AmortizationOfLongTermFinancingLiabilityForLeasedFacility
|
2872000 | USD |
| CY2012 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
8571000 | USD |
| CY2011 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
9845000 | USD |
| CY2012 | isis |
Income Losses Related To Patents And Property Plant And Equipment
IncomeLossesRelatedToPatentsAndPropertyPlantAndEquipment
|
-825000 | USD |
| CY2011 | isis |
Income Losses Related To Patents And Property Plant And Equipment
IncomeLossesRelatedToPatentsAndPropertyPlantAndEquipment
|
-1924000 | USD |
| CY2012 | isis |
Increase Decrease In Contracts Receivable Net
IncreaseDecreaseInContractsReceivableNet
|
-6399000 | USD |
| CY2011 | isis |
Increase Decrease In Contracts Receivable Net
IncreaseDecreaseInContractsReceivableNet
|
5679000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Inventories
IncreaseDecreaseInInventories
|
1982000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Inventories
IncreaseDecreaseInInventories
|
1655000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Other Operating Assets
IncreaseDecreaseInOtherOperatingAssets
|
-279000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Other Operating Assets
IncreaseDecreaseInOtherOperatingAssets
|
-914000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
|
1292000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
|
875000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Other Employee Related Liabilities
IncreaseDecreaseInOtherEmployeeRelatedLiabilities
|
2352000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Deferred Liabilities
IncreaseDecreaseInDeferredLiabilities
|
255000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Deferred Liabilities
IncreaseDecreaseInDeferredLiabilities
|
382000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Accrued Liabilities
IncreaseDecreaseInAccruedLiabilities
|
-3254000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Accrued Liabilities
IncreaseDecreaseInAccruedLiabilities
|
6273000 | USD |
| CY2012 | us-gaap |
Increase Decrease In Deferred Revenue
IncreaseDecreaseInDeferredRevenue
|
48523000 | USD |
| CY2011 | us-gaap |
Increase Decrease In Deferred Revenue
IncreaseDecreaseInDeferredRevenue
|
-70857000 | USD |
| CY2013 | isis |
Increase Decrease In Contracts Receivable Net
IncreaseDecreaseInContractsReceivableNet
|
10580000 | USD |
| CY2012 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
217877000 | USD |
| CY2012 | us-gaap |
Net Cash Provided By Used In Operating Activities Continuing Operations
NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
|
1876000 | USD |
| CY2011 | us-gaap |
Net Cash Provided By Used In Operating Activities Continuing Operations
NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
|
-111929000 | USD |
| CY2011 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
371108000 | USD |
| CY2012 | us-gaap |
Proceeds From Sale And Maturity Of Available For Sale Securities
ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
|
242659000 | USD |
| CY2011 | us-gaap |
Proceeds From Sale And Maturity Of Available For Sale Securities
ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
|
488918000 | USD |
| CY2012 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
1479000 | USD |
| CY2011 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
10203000 | USD |
| CY2012 | isis |
Payments To Acquire Licenses And Other Assets
PaymentsToAcquireLicensesAndOtherAssets
|
3691000 | USD |
| CY2011 | isis |
Payments To Acquire Licenses And Other Assets
PaymentsToAcquireLicensesAndOtherAssets
|
3667000 | USD |
| CY2012 | isis |
Payments To Acquire Previously Unissued Stock Sold By Subsidiary Or Equity Investee
PaymentsToAcquirePreviouslyUnissuedStockSoldBySubsidiaryOrEquityInvestee
|
3000000 | USD |
| CY2012 | isis |
Purchases Of Strategic Investments
PurchasesOfStrategicInvestments
|
790000 | USD |
| CY2011 | isis |
Purchases Of Strategic Investments
PurchasesOfStrategicInvestments
|
359000 | USD |
| CY2011 | us-gaap |
Net Cash Provided By Used In Investing Activities Continuing Operations
NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
|
108026000 | USD |
| CY2012 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
9470000 | USD |
| CY2011 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
3567000 | USD |
| CY2012 | us-gaap |
Proceeds From Convertible Debt
ProceedsFromConvertibleDebt
|
194697000 | USD |
| CY2012 | us-gaap |
Repayments Of Subordinated Debt
RepaymentsOfSubordinatedDebt
|
163718000 | USD |
| CY2012 | isis |
Proceeds From Equipment Financing Arrangement
ProceedsFromEquipmentFinancingArrangement
|
9100000 | USD |
| CY2011 | isis |
Proceeds From Equipment Financing Arrangement
ProceedsFromEquipmentFinancingArrangement
|
1625000 | USD |
| CY2012 | us-gaap |
Repayments Of Long Term Debt And Capital Securities
RepaymentsOfLongTermDebtAndCapitalSecurities
|
10419000 | USD |
| CY2011 | us-gaap |
Repayments Of Long Term Debt And Capital Securities
RepaymentsOfLongTermDebtAndCapitalSecurities
|
5864000 | USD |
| CY2012 | us-gaap |
Net Cash Provided By Used In Financing Activities Continuing Operations
NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
|
39130000 | USD |
| CY2011 | us-gaap |
Net Cash Provided By Used In Financing Activities Continuing Operations
NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
|
-672000 | USD |
| CY2013 | us-gaap |
Stock Issued During Period Value Share Based Compensation Gross
StockIssuedDuringPeriodValueShareBasedCompensationGross
|
62958000 | USD |
| CY2013 | us-gaap |
Profit Loss
ProfitLoss
|
-60644000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
10253000 | USD |
| CY2013Q1 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.02 | |
| CY2013Q2 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.09 | |
| CY2013 | us-gaap |
Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
|
173292000 | USD |
| CY2011 | us-gaap |
Net Cash Provided By Used In Continuing Operations
NetCashProvidedByUsedInContinuingOperations
|
-4575000 | USD |
| CY2013 | us-gaap |
Proceeds From Issuance Of Common Stock
ProceedsFromIssuanceOfCommonStock
|
173292000 | USD |
| CY2013 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
11418000 | USD |
| CY2011 | us-gaap |
Interest Paid
InterestPaid
|
4804000 | USD |
| CY2012 | us-gaap |
Income Taxes Paid Net
IncomeTaxesPaidNet
|
2000 | USD |
| CY2012 | us-gaap |
Adjustments To Additional Paid In Capital Equity Component Of Convertible Debt
AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
|
57560000 | USD |
| CY2013 | us-gaap |
Lease And Rental Expense
LeaseAndRentalExpense
|
1800000 | USD |
| CY2012 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
8571000 | USD |
| CY2012Q4 | us-gaap |
Stockholders Equity Including Portion Attributable To Noncontrolling Interest
StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
|
182766000 | USD |
| CY2012 | us-gaap |
Lease And Rental Expense
LeaseAndRentalExpense
|
1900000 | USD |
| CY2011 | us-gaap |
Lease And Rental Expense
LeaseAndRentalExpense
|
4600000 | USD |
| CY2013Q3 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.21 | |
| CY2013Q4 | us-gaap |
Stockholders Equity Including Portion Attributable To Noncontrolling Interest
StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
|
378390000 | USD |
| CY2012Q4 | us-gaap |
Deferred Rent Credit
DeferredRentCredit
|
1400000 | USD |
| CY2013Q4 | us-gaap |
Deferred Rent Credit
DeferredRentCredit
|
1600000 | USD |
| CY2011 | us-gaap |
Income Taxes Paid Net
IncomeTaxesPaidNet
|
2000 | USD |
| CY2012 | isis |
Noncash Capital And Patent Expenditures
NoncashCapitalAndPatentExpenditures
|
647000 | USD |
| CY2011 | isis |
Noncash Capital And Patent Expenditures
NoncashCapitalAndPatentExpenditures
|
902000 | USD |
| CY2011 | isis |
Capitalized Costs And Financing Liability
CapitalizedCostsAndFinancingLiability
|
59730000 | USD |
| CY2010Q4 | us-gaap |
Stockholders Equity Including Portion Attributable To Noncontrolling Interest
StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
|
244542000 | USD |
| CY2011 | us-gaap |
Stock Issued During Period Value Share Based Compensation Gross
StockIssuedDuringPeriodValueShareBasedCompensationGross
|
3567000 | USD |
| CY2013 | us-gaap |
Net Cash Provided By Used In Operating Activities Continuing Operations
NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
|
63493000 | USD |
| CY2013 | us-gaap |
Net Cash Provided By Used In Investing Activities Continuing Operations
NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
|
-255726000 | USD |
| CY2013 | us-gaap |
Net Cash Provided By Used In Financing Activities Continuing Operations
NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
|
227724000 | USD |
| CY2013 | us-gaap |
Net Cash Provided By Used In Continuing Operations
NetCashProvidedByUsedInContinuingOperations
|
35491000 | USD |
| CY2011 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
9845000 | USD |
| CY2011Q4 | us-gaap |
Stockholders Equity Including Portion Attributable To Noncontrolling Interest
StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
|
171434000 | USD |
| CY2012 | us-gaap |
Stock Issued During Period Value Share Based Compensation Gross
StockIssuedDuringPeriodValueShareBasedCompensationGross
|
9470000 | USD |
| CY2012 | us-gaap |
Adjustments To Additional Paid In Capital Equity Component Of Convertible Debt Subsequent Adjustments
AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments
|
12041000 | USD |
| CY2012Q4 | isis |
Long Term Debt And Other
LongTermDebtAndOther
|
226821000 | USD |
| CY2013Q4 | isis |
Long Term Debt And Other
LongTermDebtAndOther
|
232572000 | USD |
| CY2013Q4 | us-gaap |
Long Term Debt And Capital Lease Obligations Current
LongTermDebtAndCapitalLeaseObligationsCurrent
|
4408000 | USD |
| CY2012Q4 | isis |
Long Term Debt And Other Noncurrent
LongTermDebtAndOtherNoncurrent
|
221942000 | USD |
| CY2013Q4 | isis |
Long Term Debt And Other Noncurrent
LongTermDebtAndOtherNoncurrent
|
228164000 | USD |
| CY2013 | us-gaap |
Amortization Of Debt Discount Premium
AmortizationOfDebtDiscountPremium
|
6300000 | USD |
| CY2011 | us-gaap |
Amortization Of Debt Discount Premium
AmortizationOfDebtDiscountPremium
|
8600000 | USD |
| CY2012 | us-gaap |
Amortization Of Debt Discount Premium
AmortizationOfDebtDiscountPremium
|
8400000 | USD |
| CY2013 | isis |
Leases Number Of Buildings
LeasesNumberOfBuildings
|
3 | item |
| CY2013Q4 | us-gaap |
Area Of Real Estate Property
AreaOfRealEstateProperty
|
231000 | |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due Current
OperatingLeasesFutureMinimumPaymentsDueCurrent
|
1470000 | USD |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due In Two Years
OperatingLeasesFutureMinimumPaymentsDueInTwoYears
|
1395000 | USD |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due In Three Years
OperatingLeasesFutureMinimumPaymentsDueInThreeYears
|
1538000 | USD |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due In Four Years
OperatingLeasesFutureMinimumPaymentsDueInFourYears
|
1481000 | USD |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due In Five Years
OperatingLeasesFutureMinimumPaymentsDueInFiveYears
|
1451000 | USD |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due Thereafter
OperatingLeasesFutureMinimumPaymentsDueThereafter
|
19126000 | USD |
| CY2013Q4 | us-gaap |
Operating Leases Future Minimum Payments Due
OperatingLeasesFutureMinimumPaymentsDue
|
26461000 | USD |
| CY2013Q4 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.21 | |
| CY2013Q2 | us-gaap |
Proceeds From Issuance Of Common Stock
ProceedsFromIssuanceOfCommonStock
|
173300000 | USD |
| CY2012Q4 | isis |
Investments Cost Basis
InvestmentsCostBasis
|
271569000 | USD |
| CY2013Q4 | isis |
Investments Cost Basis
InvestmentsCostBasis
|
527873000 | USD |
| CY2013 | isis |
Amortization Of Debt Discount Premium Two
AmortizationOfDebtDiscountPremiumTwo
|
6344000 | USD |
| CY2012Q2 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.01 | |
| CY2012Q3 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.37 | |
| CY2013 | isis |
Amortization Of Long Term Financing Liability For Leased Facility
AmortizationOfLongTermFinancingLiabilityForLeasedFacility
|
6567000 | USD |
| CY2012Q1 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.24 | |
| CY2013Q4 | isis |
Significant Equity Investment
SignificantEquityInvestment
|
52096000 | USD |
| CY2013Q4 | us-gaap |
Other Assets Current
OtherAssetsCurrent
|
7518000 | USD |
| CY2013Q4 | us-gaap |
Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
|
496788000 | USD |
| CY2013Q4 | us-gaap |
Receivables Long Term Contracts Or Programs
ReceivablesLongTermContractsOrPrograms
|
11102000 | USD |
| CY2013 | isis |
Licensing And Royalty Revenue
LicensingAndRoyaltyRevenue
|
3091000 | USD |
| CY2013 | isis |
Research Development And Patent Expense
ResearchDevelopmentAndPatentExpense
|
184033000 | USD |
| CY2013 | us-gaap |
General And Administrative Expense
GeneralAndAdministrativeExpense
|
14918000 | USD |
| CY2013 | us-gaap |
Investment Income Net
InvestmentIncomeNet
|
2085000 | USD |
| CY2013 | us-gaap |
Interest Expense
InterestExpense
|
19355000 | USD |
| CY2011Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
65477000 | USD |
| CY2010Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
70052000 | USD |
| CY2013Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
159973000 | USD |
| CY2013Q4 | isis |
Licenses Net
LicensesNet
|
4572000 | USD |
| CY2013Q4 | isis |
Patents Net
PatentsNet
|
15517000 | USD |
| CY2013Q4 | isis |
Deposits And Other Assets Noncurrent
DepositsAndOtherAssetsNoncurrent
|
5359000 | USD |
| CY2013Q4 | us-gaap |
Accounts Payable Current
AccountsPayableCurrent
|
11009000 | USD |
| CY2013Q4 | us-gaap |
Employee Related Liabilities Current
EmployeeRelatedLiabilitiesCurrent
|
12168000 | USD |
| CY2013Q4 | us-gaap |
Accrued Liabilities Current
AccruedLiabilitiesCurrent
|
22092000 | USD |
| CY2013Q4 | us-gaap |
Deferred Revenue Current
DeferredRevenueCurrent
|
48135000 | USD |
| CY2013Q4 | us-gaap |
Deferred Revenue Noncurrent
DeferredRevenueNoncurrent
|
142790000 | USD |
| CY2013Q4 | us-gaap |
Convertible Debt Noncurrent
ConvertibleDebtNoncurrent
|
150334000 | USD |
| CY2013Q4 | isis |
Capital Lease And Other Long Term Borrowings Non Current
CapitalLeaseAndOtherLongTermBorrowingsNonCurrent
|
6542000 | USD |
| CY2013Q4 | isis |
Long Term Financing Obligation
LongTermFinancingObligation
|
71288000 | USD |
| CY2013Q4 | us-gaap |
Common Stock Value
CommonStockValue
|
116000 | USD |
| CY2013Q4 | us-gaap |
Additional Paid In Capital Common Stock
AdditionalPaidInCapitalCommonStock
|
1324804000 | USD |
| CY2013Q4 | us-gaap |
Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
|
-967610000 | USD |
| CY2013 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.55 | |
| CY2013 | us-gaap |
Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
|
110502000 | shares |
| CY2013 | us-gaap |
Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
|
110502000 | shares |
| CY2013 | us-gaap |
Depreciation
Depreciation
|
6591000 | USD |
| CY2013 | isis |
Amortization Of Patents
AmortizationOfPatents
|
1184000 | USD |
| CY2013 | isis |
Amortization Of Licenses
AmortizationOfLicenses
|
2007000 | USD |
| CY2013 | us-gaap |
Investment Income Net Amortization Of Discount And Premium
InvestmentIncomeNetAmortizationOfDiscountAndPremium
|
-5572000 | USD |
| CY2013 | us-gaap |
Amortization Of Financing Costs
AmortizationOfFinancingCosts
|
415000 | USD |
| CY2013 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
11418000 | USD |
| CY2013 | isis |
Income Losses Related To Patents And Property Plant And Equipment
IncomeLossesRelatedToPatentsAndPropertyPlantAndEquipment
|
-6306000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Inventories
IncreaseDecreaseInInventories
|
1912000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Other Operating Assets
IncreaseDecreaseInOtherOperatingAssets
|
1091000 | USD |
| CY2013 | us-gaap |
Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
|
66000 | USD |
| CY2013Q4 | us-gaap |
Available For Sale Securities Continuous Unrealized Loss Position Twelve Months Or Longer Fair Value
AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue
|
12358000 | USD |
| CY2013Q4 | isis |
Available For Sale Securities Continuous Unrealized Loss Position More Than12 Months Aggregate Losses Accumulated In Investments
AvailableForSaleSecuritiesContinuousUnrealizedLossPositionMoreThan12MonthsAggregateLossesAccumulatedInInvestments
|
12000 | USD |
| CY2013Q4 | us-gaap |
Available For Sale Securities Continuous Unrealized Loss Position Fair Value
AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue
|
282228000 | USD |
| CY2013Q4 | isis |
Available For Sale Securities Continuous Unrealized Loss Position Aggregate Losses Accumulated In Investments
AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAccumulatedInInvestments
|
619000 | USD |
| CY2012 | us-gaap |
Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent
OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent
|
13250000 | USD |
| CY2011 | us-gaap |
Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent
OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent
|
-1719000 | USD |
| CY2013 | us-gaap |
Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent
OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent
|
8600000 | USD |
