$IONS
IONIS PHARMACEUTICALS INC Stock $ions

$ions Overview Financials Valuation SEC Filings Company Website

2012 Q4 Form 10-K Financial Statement

#000110465913016208 Filed on February 28, 2013

Income Statement

Concept	2012 Q4	2012 Q3	2012 Q2
Revenue	$19.87M	$11.60M	$47.34M
YoY Change	-38.67%	-43.99%	90.71%
Cost Of Revenue	$42.60M
YoY Change
Gross Profit	-$22.70M
YoY Change
Gross Profit Margin	-114.23%
Selling, General & Admin	$3.200M	$3.100M	$3.200M
YoY Change	-15.79%	0.0%	10.34%
% of Gross Profit
Research & Development		$35.60M	$40.44M
YoY Change		-10.83%	12.29%
% of Gross Profit
Depreciation & Amortization
YoY Change
% of Gross Profit
Operating Expenses	$45.99M	$39.65M	$43.64M
YoY Change	-9.85%	-7.86%	12.24%
Operating Profit	-$26.12M	-$28.05M	$3.696M
YoY Change	40.3%	25.68%	-126.29%
Interest Expense	$15.10M	$5.937M	$5.219M
YoY Change	-1178.57%	24.39%	51.85%
% of Operating Profit			141.21%
Other Income/Expense, Net	-$231.4M
YoY Change
Pretax Income	-$242.4M	-$38.35M	-$1.207M
YoY Change	1112.0%	42.64%	-93.25%
Income Tax	-$8.400M	-$706.0K	$0.00
% Of Pretax Income
Net Earnings	-$234.0M	-$37.60M	-$1.200M
YoY Change	1070.0%	39.78%	-93.3%
Net Earnings / Revenue	-1177.48%	-324.11%	-2.53%
Basic Earnings Per Share
Diluted Earnings Per Share	-$0.03	-$0.37	-$0.01
COMMON SHARES
Basic Shares Outstanding	101.2M shares	100.7M shares	100.2M shares
Diluted Shares Outstanding		100.7M shares	100.2M shares

Balance Sheet

Concept	2012 Q4	2012 Q3	2012 Q2
SHORT-TERM ASSETS
Cash & Short-Term Investments	$374.4M	$343.6M	$336.0M
YoY Change	8.96%	-5.82%	-14.98%
Cash & Equivalents	$124.5M	$84.56M	$85.65M
Short-Term Investments	$250.0M	$259.0M	$250.4M
Other Short-Term Assets	$8.727M	$7.800M	$5.700M
YoY Change	61.16%	2.63%	-25.0%
Inventory	$6.100M	$6.700M	$7.100M
Prepaid Expenses
Receivables	$500.0K	$3.500M	$1.600M
Other Receivables	$0.00	$0.00	$0.00
Total Short-Term Assets	$423.4M	$361.6M	$350.4M
YoY Change	17.58%	-4.11%	-14.68%
LONG-TERM ASSETS
Property, Plant & Equipment	$91.08M	$92.60M	$94.00M
YoY Change	-5.72%	-5.51%	6.82%
Goodwill
YoY Change
Intangibles
YoY Change
Long-Term Investments		-$5.563M	-$5.563M
YoY Change
Other Assets	$5.900M	$6.100M	$2.500M
YoY Change	110.71%	96.77%	-24.24%
Total Long-Term Assets	$122.2M	$124.1M	$122.0M
YoY Change	-2.01%	-3.56%	2.59%
TOTAL ASSETS
Total Short-Term Assets	$423.4M	$361.6M	$350.4M
Total Long-Term Assets	$122.2M	$124.1M	$122.0M
Total Assets	$545.7M	$485.7M	$472.4M
YoY Change	12.54%	-3.97%	-10.8%
SHORT-TERM LIABILITIES
YoY Change
Accounts Payable	$10.24M	$5.256M	$6.200M
YoY Change	23.36%	-21.55%	100.0%
Accrued Expenses	$15.40M	$11.90M	$20.60M
YoY Change	-17.44%	-41.38%	34.64%
Deferred Revenue
YoY Change
Short-Term Debt	$0.00	$0.00	$0.00
YoY Change
Long-Term Debt Due	$4.900M	$5.200M	$5.300M
YoY Change	44.12%	23.81%	8.16%
Total Short-Term Liabilities	$74.32M	$51.60M	$55.06M
YoY Change	-2.35%	-38.2%	-40.15%
LONG-TERM LIABILITIES
Long-Term Debt	$221.9M	$221.3M	$225.7M
YoY Change	2.97%	3.95%	12.12%
Other Long-Term Liabilities	$66.70M	$42.50M	$37.30M
YoY Change	204.57%	88.05%	54.77%
Total Long-Term Liabilities	$288.6M	$263.8M	$263.0M
YoY Change	21.57%	12.02%	16.68%
TOTAL LIABILITIES
Total Short-Term Liabilities	$74.32M	$51.60M	$55.06M
Total Long-Term Liabilities	$288.6M	$263.8M	$263.0M
Total Liabilities	$362.9M	$315.4M	$318.1M
YoY Change	15.78%	-1.13%	0.21%
SHAREHOLDERS EQUITY
Retained Earnings	-$907.0M	-$904.3M
YoY Change	7.78%
Common Stock	$1.077B	$1.074B
YoY Change	6.27%
Preferred Stock
YoY Change
Treasury Stock (at cost)
YoY Change
Treasury Stock Shares
Shareholders Equity	$182.8M	$170.3M	$154.3M
YoY Change
Total Liabilities & Shareholders Equity	$545.7M	$485.7M	$472.4M
YoY Change	12.54%	-3.97%	-10.8%

Cashflow Statement

Concept	2012 Q4	2012 Q3	2012 Q2
OPERATING ACTIVITIES
Net Income	-$234.0M	-$37.60M	-$1.200M
YoY Change	1070.0%	39.78%	-93.3%
Depreciation, Depletion And Amortization
YoY Change
Cash From Operating Activities	$36.10M	-$24.90M	-$2.600M
YoY Change	-259.03%	7.33%	-90.08%
INVESTING ACTIVITIES
Capital Expenditures	-$500.0K	-$100.0K	-$800.0K
YoY Change	-61.54%	-96.55%	-76.47%
Acquisitions
YoY Change
Other Investing Activities	$5.500M	-$10.40M	$24.80M
YoY Change	-83.63%	285.19%	-11.43%
Cash From Investing Activities	$5.000M	-$10.60M	$24.10M
YoY Change	-84.52%	85.96%	-2.43%
FINANCING ACTIVITIES
Cash Dividend Paid
YoY Change
Common Stock Issuance & Retirement, Net
YoY Change
Debt Paid & Issued, Net
YoY Change
Cash From Financing Activities	-1.200M	34.40M	7.800M
YoY Change	-300.0%	-3922.22%	2500.0%
NET CHANGE
Cash From Operating Activities	36.10M	-24.90M	-2.600M
Cash From Investing Activities	5.000M	-10.60M	24.10M
Cash From Financing Activities	-1.200M	34.40M	7.800M
Net Change In Cash	39.90M	-1.100M	29.30M
YoY Change	291.18%	-96.31%	-2541.67%
FREE CASH FLOW
Cash From Operating Activities	$36.10M	-$24.90M	-$2.600M
Capital Expenditures	-$500.0K	-$100.0K	-$800.0K
Free Cash Flow	$36.60M	-$24.80M	-$1.800M
YoY Change	-271.03%	22.17%	-92.11%

Facts In Submission

Frame	Concept Type	Concept / XBRL Key	Value	Unit
CY2012	us-gaap	Income Taxes Paid Net IncomeTaxesPaidNet	2000	USD
CY2012	dei	Entity Registrant Name EntityRegistrantName	ISIS PHARMACEUTICALS INC
CY2012	dei	Entity Central Index Key EntityCentralIndexKey	0000874015
CY2012	dei	Document Type DocumentType	10-K
CY2012	dei	Document Period End Date DocumentPeriodEndDate	2012-12-31
CY2012	dei	Amendment Flag AmendmentFlag	false
CY2012	dei	Current Fiscal Year End Date CurrentFiscalYearEndDate	--12-31
CY2012	dei	Entity Well Known Seasoned Issuer EntityWellKnownSeasonedIssuer	Yes
CY2012	dei	Entity Current Reporting Status EntityCurrentReportingStatus	Yes
CY2012	dei	Entity Filer Category EntityFilerCategory	Large Accelerated Filer
CY2013Q1	dei	Entity Common Stock Shares Outstanding EntityCommonStockSharesOutstanding	101826748	shares
CY2012	dei	Document Fiscal Year Focus DocumentFiscalYearFocus	2012
CY2012	dei	Document Fiscal Period Focus DocumentFiscalPeriodFocus	FY
CY2012	dei	Entity Voluntary Filers EntityVoluntaryFilers	No
CY2012Q2	dei	Entity Public Float EntityPublicFloat	1011059448	USD
CY2011Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	65477000	USD
CY2011Q4	us-gaap	Available For Sale Securities Debt Securities Current AvailableForSaleSecuritiesDebtSecuritiesCurrent	278187000	USD
CY2011Q4	us-gaap	Receivables Long Term Contracts Or Programs ReceivablesLongTermContractsOrPrograms	6921000	USD
CY2011Q4	us-gaap	Inventory Raw Materials Net Of Reserves InventoryRawMaterialsNetOfReserves	4139000	USD
CY2011Q4	us-gaap	Other Assets Current OtherAssetsCurrent	5415000	USD
CY2011Q4	us-gaap	Assets Current AssetsCurrent	360139000	USD
CY2011Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	96615000	USD
CY2011Q4	isis	Licenses Net LicensesNet	9036000	USD
CY2011Q4	isis	Patents Net PatentsNet	16259000	USD
CY2011Q4	isis	Deposits And Other Assets Noncurrent DepositsAndOtherAssetsNoncurrent	2845000	USD
CY2011Q4	us-gaap	Assets Assets	484894000	USD
CY2011Q4	us-gaap	Accounts Payable Current AccountsPayableCurrent	8300000	USD
CY2011Q4	us-gaap	Employee Related Liabilities Current EmployeeRelatedLiabilitiesCurrent	9183000	USD
CY2011Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	18655000	USD
CY2011Q4	us-gaap	Long Term Debt And Capital Lease Obligations Current LongTermDebtAndCapitalLeaseObligationsCurrent	3390000	USD
CY2011Q4	us-gaap	Deferred Revenue Current DeferredRevenueCurrent	36584000	USD
CY2011Q4	us-gaap	Liabilities Current LiabilitiesCurrent	76112000	USD
CY2011Q4	us-gaap	Deferred Revenue Noncurrent DeferredRevenueNoncurrent	17474000	USD
CY2011Q4	us-gaap	Common Stock Value CommonStockValue	100000	USD
CY2010	us-gaap	Increase Decrease In Other Employee Related Liabilities IncreaseDecreaseInOtherEmployeeRelatedLiabilities	394000	USD
CY2010	us-gaap	Increase Decrease In Accrued Liabilities IncreaseDecreaseInAccruedLiabilities	1013000	USD
CY2011Q4	us-gaap	Convertible Long Term Notes Payable ConvertibleLongTermNotesPayable	141448000	USD
CY2011Q4	isis	Capital Lease And Other Long Term Borrowings Non Current CapitalLeaseAndOtherLongTermBorrowingsNonCurrent	4125000	USD
CY2011Q4	isis	Long Term Financing Obligation LongTermFinancingObligation	69877000	USD
CY2011Q4	us-gaap	Liabilities Liabilities	313460000	USD
CY2011Q4	us-gaap	Additional Paid In Capital Common Stock AdditionalPaidInCapitalCommonStock	1013592000	USD
CY2011Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-770000	USD
CY2011Q4	us-gaap	Retained Earnings Accumulated Deficit RetainedEarningsAccumulatedDeficit	-841488000	USD
CY2011Q4	us-gaap	Stockholders Equity StockholdersEquity	171434000	USD
CY2011Q2	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-17889000	USD
CY2012Q4	us-gaap	Assets Current AssetsCurrent	423438000	USD
CY2012Q4	us-gaap	Assets Assets	545686000	USD
CY2012Q4	us-gaap	Liabilities Current LiabilitiesCurrent	74322000	USD
CY2012Q4	us-gaap	Convertible Debt Noncurrent ConvertibleDebtNoncurrent	143990000	USD
CY2012Q4	us-gaap	Liabilities Liabilities	362920000	USD
CY2012Q4	us-gaap	Stockholders Equity StockholdersEquity	182766000	USD
CY2012Q4	us-gaap	Liabilities And Stockholders Equity LiabilitiesAndStockholdersEquity	545686000	USD
CY2011Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.001
CY2012Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.001
CY2011Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	200000000	shares
CY2012Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	200000000	shares
CY2011Q4	us-gaap	Common Stock Shares Issued CommonStockSharesIssued	100042976	shares
CY2011	isis	Licensing And Royalty Revenue LicensingAndRoyaltyRevenue	2896000	USD
CY2011	us-gaap	Revenues Revenues	99086000	USD
CY2011	us-gaap	Research And Development Expense ResearchAndDevelopmentExpense	157397000	USD
CY2011	us-gaap	General And Administrative Expense GeneralAndAdministrativeExpense	12789000	USD
CY2011	us-gaap	Operating Expenses OperatingExpenses	170186000	USD
CY2011	us-gaap	Operating Income Loss OperatingIncomeLoss	-71100000	USD
CY2011	us-gaap	Income Loss From Equity Method Investments IncomeLossFromEquityMethodInvestments	-3554000	USD
CY2011	us-gaap	Investment Income Net InvestmentIncomeNet	2414000	USD
CY2011	us-gaap	Interest Expense InterestExpense	16732000	USD
CY2012Q4	us-gaap	Common Stock Shares Issued CommonStockSharesIssued	101481134	shares
CY2011Q4	us-gaap	Common Stock Shares Outstanding CommonStockSharesOutstanding	100042976	shares
CY2012Q4	us-gaap	Common Stock Shares Outstanding CommonStockSharesOutstanding	101481134	shares
CY2012	us-gaap	Revenues Revenues	102049000	USD
CY2012	us-gaap	Operating Expenses OperatingExpenses	170973000	USD
CY2012	us-gaap	Operating Income Loss OperatingIncomeLoss	-68924000	USD
CY2012	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-74587000	USD
CY2012	isis	Research And Development Revenue Under Collaborative Agreements ResearchAndDevelopmentRevenueUnderCollaborativeAgreements	99100000	USD
CY2012	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-65478000	USD
CY2011	isis	Research And Development Revenue Under Collaborative Agreements ResearchAndDevelopmentRevenueUnderCollaborativeAgreements	96190000	USD
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CY2011	us-gaap	Gain Loss On Investments GainLossOnInvestments	4182000	USD
CY2011	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-84790000	USD
CY2012	isis	Licensing And Royalty Revenue LicensingAndRoyaltyRevenue	2949000	USD
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CY2011	us-gaap	Earnings Per Share Basic And Diluted EarningsPerShareBasicAndDiluted	-0.85
CY2011	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	99656000	shares
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CY2010	isis	Licensing And Royalty Revenue LicensingAndRoyaltyRevenue	5552000	USD
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CY2010	us-gaap	General And Administrative Expense GeneralAndAdministrativeExpense	11669000	USD
CY2010	us-gaap	Operating Expenses OperatingExpenses	156829000	USD
CY2010	us-gaap	Operating Income Loss OperatingIncomeLoss	-48356000	USD
CY2012	us-gaap	Investment Income Net InvestmentIncomeNet	1844000	USD
CY2010	us-gaap	Income Loss From Equity Method Investments IncomeLossFromEquityMethodInvestments	-6879000	USD
CY2010	us-gaap	Investment Income Net InvestmentIncomeNet	3370000	USD
CY2010	us-gaap	Interest Expense InterestExpense	13232000	USD
CY2010	us-gaap	Gain Loss On Investments GainLossOnInvestments	-713000	USD
CY2010	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-61159000	USD
CY2012	us-gaap	Research And Development Expense ResearchAndDevelopmentExpense	158458000	USD
CY2010	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-61251000	USD
CY2010	us-gaap	Earnings Per Share Basic And Diluted EarningsPerShareBasicAndDiluted	-0.62
CY2010	isis	Income Losses Related To Patents And Property Plant And Equipment IncomeLossesRelatedToPatentsAndPropertyPlantAndEquipment	-1512000	USD
CY2010	isis	Increase Decrease In Contracts Receivable Net IncreaseDecreaseInContractsReceivableNet	-10479000	USD
CY2010	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	-284000	USD
CY2010	us-gaap	Increase Decrease In Other Operating Assets IncreaseDecreaseInOtherOperatingAssets	943000	USD
CY2010	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	1325000	USD
CY2010	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	99143000	shares
CY2010	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	99143000	shares
CY2012	us-gaap	Gains Losses On Extinguishment Of Debt GainsLossesOnExtinguishmentOfDebt	-4770000	USD
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CY2012	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-52228000	USD
CY2010	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-62455000	USD
CY2009Q4	us-gaap	Stockholders Equity Including Portion Attributable To Noncontrolling Interest StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest	302065000	USD
CY2010	us-gaap	Profit Loss ProfitLoss	-61251000	USD
CY2010	us-gaap	Stock Issued During Period Value Share Based Compensation Gross StockIssuedDuringPeriodValueShareBasedCompensationGross	4356000	USD
CY2010	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	12159000	USD
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CY2012	us-gaap	Profit Loss ProfitLoss	-65478000	USD
CY2012	us-gaap	Depreciation Depreciation	7074000	USD
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CY2011	us-gaap	Depreciation Depreciation	6594000	USD
CY2011	isis	Amortization Of Patents AmortizationOfPatents	1938000	USD
CY2011	isis	Amortization Of Licenses AmortizationOfLicenses	3252000	USD
CY2011	us-gaap	Investment Income Net Amortization Of Discount And Premium InvestmentIncomeNetAmortizationOfDiscountAndPremium	-5410000	USD
CY2011	us-gaap	Amortization Of Financing Costs AmortizationOfFinancingCosts	507000	USD
CY2011	us-gaap	Share Based Compensation ShareBasedCompensation	9845000	USD
CY2011	isis	Income Losses Related To Patents And Property Plant And Equipment IncomeLossesRelatedToPatentsAndPropertyPlantAndEquipment	-1924000	USD
CY2011	isis	Increase Decrease In Contracts Receivable Net IncreaseDecreaseInContractsReceivableNet	5679000	USD
CY2011	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	1655000	USD
CY2011	us-gaap	Increase Decrease In Other Operating Assets IncreaseDecreaseInOtherOperatingAssets	-914000	USD
CY2011	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	875000	USD
CY2011	us-gaap	Increase Decrease In Other Employee Related Liabilities IncreaseDecreaseInOtherEmployeeRelatedLiabilities	2352000	USD
CY2011	us-gaap	Increase Decrease In Deferred Liabilities IncreaseDecreaseInDeferredLiabilities	382000	USD
CY2011	us-gaap	Increase Decrease In Accrued Liabilities IncreaseDecreaseInAccruedLiabilities	6273000	USD
CY2011	us-gaap	Increase Decrease In Deferred Revenue IncreaseDecreaseInDeferredRevenue	-70857000	USD
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CY2011	us-gaap	Proceeds From Sale And Maturity Of Available For Sale Securities ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities	488918000	USD
CY2011	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	10203000	USD
CY2011	isis	Payments To Acquire Licenses And Other Assets PaymentsToAcquireLicensesAndOtherAssets	3667000	USD
CY2011	isis	Purchases Of Strategic Investments PurchasesOfStrategicInvestments	359000	USD
CY2011	isis	Proceeds From The Sale Of Strategic Investments ProceedsFromTheSaleOfStrategicInvestments	4445000	USD
CY2011	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	3567000	USD
CY2011	isis	Proceeds From Equipment Financing Arrangement ProceedsFromEquipmentFinancingArrangement	1625000	USD
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CY2011	us-gaap	Interest Paid InterestPaid	4804000	USD
CY2011	us-gaap	Income Taxes Paid Net IncomeTaxesPaidNet	2000	USD
CY2011	isis	Noncash Capital And Patent Expenditures NoncashCapitalAndPatentExpenditures	902000	USD
CY2011	isis	Capitalized Costs And Financing Liability CapitalizedCostsAndFinancingLiability	59730000	USD
CY2010	us-gaap	Depreciation Depreciation	4840000	USD
CY2010	isis	Amortization Of Patents AmortizationOfPatents	1961000	USD
CY2010	isis	Amortization Of Licenses AmortizationOfLicenses	2376000	USD
CY2010	us-gaap	Investment Income Net Amortization Of Discount And Premium InvestmentIncomeNetAmortizationOfDiscountAndPremium	-5075000	USD
CY2010	us-gaap	Amortization Of Financing Costs AmortizationOfFinancingCosts	507000	USD
CY2010	us-gaap	Capital Lease Obligations Incurred CapitalLeaseObligationsIncurred	770000	USD
CY2012	us-gaap	Proceeds From Convertible Debt ProceedsFromConvertibleDebt	194697000	USD
CY2012	us-gaap	Repayments Of Subordinated Debt RepaymentsOfSubordinatedDebt	163718000	USD
CY2010Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	70052000	USD
CY2010	us-gaap	Increase Decrease In Deferred Revenue IncreaseDecreaseInDeferredRevenue	-46810000	USD
CY2009Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	105255000	USD
CY2010	us-gaap	Payments To Acquire Available For Sale Securities Debt PaymentsToAcquireAvailableForSaleSecuritiesDebt	530137000	USD
CY2010	us-gaap	Proceeds From Sale And Maturity Of Available For Sale Securities ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities	577533000	USD
CY2010	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	13237000	USD
CY2010	us-gaap	Proceeds From Sale Of Property Plant And Equipment ProceedsFromSaleOfPropertyPlantAndEquipment	185000	USD
CY2010	us-gaap	Proceeds From Sale Of Land Held For Use ProceedsFromSaleOfLandHeldForUse	10147000	USD
CY2010	isis	Cash Flow Impact Upon Adoption Of New Accounting Standard CashFlowImpactUponAdoptionOfNewAccountingStandard	16228000	USD
CY2010	isis	Payments To Acquire Licenses And Other Assets PaymentsToAcquireLicensesAndOtherAssets	4319000	USD
CY2010	isis	Purchases Of Strategic Investments PurchasesOfStrategicInvestments	250000	USD
CY2010	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	4356000	USD
CY2010	isis	Proceeds From Equipment Financing Arrangement ProceedsFromEquipmentFinancingArrangement	4694000	USD
CY2010	us-gaap	Repayments Of Long Term Debt And Capital Securities RepaymentsOfLongTermDebtAndCapitalSecurities	4354000	USD
CY2010	us-gaap	Interest Paid InterestPaid	4889000	USD
CY2010	us-gaap	Income Taxes Paid Net IncomeTaxesPaidNet	7270000	USD
CY2010	isis	Noncash Capital And Patent Expenditures NoncashCapitalAndPatentExpenditures	922000	USD
CY2011Q3	us-gaap	Revenues Revenues	20713000	USD
CY2011Q4	us-gaap	Revenues Revenues	32403000	USD
CY2011Q1	us-gaap	Operating Expenses OperatingExpenses	37255000	USD
CY2011Q2	us-gaap	Operating Expenses OperatingExpenses	38883000	USD
CY2011Q3	us-gaap	Operating Expenses OperatingExpenses	43029000	USD
CY2011Q4	us-gaap	Operating Expenses OperatingExpenses	51019000	USD
CY2011Q1	us-gaap	Operating Income Loss OperatingIncomeLoss	-16108000	USD
CY2011Q2	us-gaap	Operating Income Loss OperatingIncomeLoss	-14060000	USD
CY2012	us-gaap	Use Of Estimates UseOfEstimates	<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="MARGIN: 0in 0in 0pt"><b><font style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman" size="2">Use of estimates</font></b></p> <p style="MARGIN: 0in 0in 0pt"><font style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman" size="2"> </font></p> <p style="MARGIN: 0in 0in 0pt; TEXT-INDENT: 0.5in"><font style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman" size="2">The preparation of consolidated financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates.</font></p></div>
CY2012	isis	Number Of Categories Of Milestone Events NumberOfCategoriesOfMilestoneEvents	3	item
CY2012	isis	Number Of Stages Of Life Cycle Of Drugs NumberOfStagesOfLifeCycleOfDrugs	3	item
CY2012Q4	us-gaap	Inventory Raw Materials Net Of Reserves InventoryRawMaterialsNetOfReserves	6121000	USD
CY2012Q4	isis	Property Plant And Equipment Gross Excluding Land PropertyPlantAndEquipmentGrossExcludingLand	135351000	USD
CY2012Q4	us-gaap	Accumulated Depreciation Depletion And Amortization Property Plant And Equipment AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment	54465000	USD
CY2012Q4	isis	Property Plant And Equipment Net Excluding Land PropertyPlantAndEquipmentNetExcludingLand	80886000	USD
CY2012Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	91084000	USD
CY2011Q4	isis	Property Plant And Equipment Gross Excluding Land PropertyPlantAndEquipmentGrossExcludingLand	133837000	USD
CY2011Q4	us-gaap	Accumulated Depreciation Depletion And Amortization Property Plant And Equipment AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment	47420000	USD
CY2011Q4	isis	Property Plant And Equipment Net Excluding Land PropertyPlantAndEquipmentNetExcludingLand	86417000	USD
CY2012	isis	Variable Interest Entity Not Primary Beneficiary Number Of Entities VariableInterestEntityNotPrimaryBeneficiaryNumberOfEntities	6	item
CY2011	isis	Variable Interest Entity Not Primary Beneficiary Number Of Entities VariableInterestEntityNotPrimaryBeneficiaryNumberOfEntities	6	item
CY2012Q4	isis	Available For Sale Securities Debt Maturities Within One Year Percentage AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage	0.56	pure
CY2012Q4	isis	Available For Sale Securities Debt Maturities After One Through Two Years Percentage AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage	0.32	pure
CY2012Q4	isis	Available For Sale Securities Debt Maturities After Two Through Three Years Percentage AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeYearsPercentage	0.12	pure
CY2012Q4	isis	Available For Sale Securities Debt Maturities Total Percentage AvailableForSaleSecuritiesDebtMaturitiesTotalPercentage	1.00	pure
CY2012Q4	isis	Available For Sale Securities Debt Maturities Within Two Years Percentage AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage	0.88	pure
CY2012Q4	isis	Number Of Privately Held Companies In Which Entity Has Equity Investment NumberOfPrivatelyHeldCompaniesInWhichEntityHasEquityInvestment	3	company
CY2012Q4	isis	Number Of Publicly Held Companies In Which Entity Has Equity Investment NumberOfPubliclyHeldCompaniesInWhichEntityHasEquityInvestment	4	company
CY2011Q4	us-gaap	Cost Method Investments CostMethodInvestments	625000	USD
CY2011Q4	us-gaap	Cost Method Investments Fair Value Disclosure CostMethodInvestmentsFairValueDisclosure	625000	USD
CY2011Q4	isis	Securities Amortized Cost Basis SecuritiesAmortizedCostBasis	280939000	USD
CY2011Q4	us-gaap	Availableforsale Securities Gross Unrealized Gain AvailableforsaleSecuritiesGrossUnrealizedGain	719000	USD
CY2011Q4	us-gaap	Available For Sale Securities Gross Unrealized Losses1 AvailableForSaleSecuritiesGrossUnrealizedLosses1	684000	USD
CY2011	us-gaap	Other Than Temporary Impairment Losses Investments Portion Recognized In Earnings Net Availableforsale Securities OtherThanTemporaryImpairmentLossesInvestmentsPortionRecognizedInEarningsNetAvailableforsaleSecurities	880000	USD
CY2011Q4	us-gaap	Investments Fair Value Disclosure InvestmentsFairValueDisclosure	280094000	USD
CY2012Q4	us-gaap	Cost Method Investments CostMethodInvestments	625000	USD
CY2012Q4	us-gaap	Cost Method Investments Fair Value Disclosure CostMethodInvestmentsFairValueDisclosure	625000	USD
CY2012Q4	isis	Securities Amortized Cost Basis SecuritiesAmortizedCostBasis	267569000	USD
CY2012Q4	us-gaap	Availableforsale Securities Gross Unrealized Gain AvailableforsaleSecuritiesGrossUnrealizedGain	22581000	USD
CY2012Q4	us-gaap	Available For Sale Securities Gross Unrealized Losses1 AvailableForSaleSecuritiesGrossUnrealizedLosses1	185000	USD
CY2012Q4	us-gaap	Investments Fair Value Disclosure InvestmentsFairValueDisclosure	289085000	USD
CY2012Q4	us-gaap	Available For Sale Securities In Unrealized Loss Positions Qualitative Disclosure Number Of Positions AvailableForSaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureNumberOfPositions	44	security
CY2012Q4	us-gaap	Available For Sale Securities Continuous Unrealized Loss Position Less Than Twelve Months Fair Value AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue	72742000	USD
CY2012Q4	us-gaap	Availableforsale Securities Continuous Unrealized Loss Position Less Than12 Months Aggregate Losses2 AvailableforsaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAggregateLosses2	-185000	USD
CY2011Q4	isis	Long Term Debt And Other LongTermDebtAndOther	218840000	USD
CY2012Q4	isis	Long Term Debt And Other LongTermDebtAndOther	226821000	USD
CY2012Q4	us-gaap	Long Term Debt And Capital Lease Obligations Current LongTermDebtAndCapitalLeaseObligationsCurrent	4879000	USD
CY2012	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	8571000	USD
CY2011	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	9845000	USD
CY2010	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	12159000	USD
CY2012	isis	Effective Income Tax Rate Reconciliation Deferred Tax EffectiveIncomeTaxRateReconciliationDeferredTax	-0.011	pure
CY2011	us-gaap	Effective Income Tax Rate Reconciliation Other Adjustments EffectiveIncomeTaxRateReconciliationOtherAdjustments	-0.005	pure
CY2012	us-gaap	Effective Income Tax Rate Reconciliation Other Adjustments EffectiveIncomeTaxRateReconciliationOtherAdjustments	-0.009	pure
CY2010	us-gaap	Effective Income Tax Rate Reconciliation Other Adjustments EffectiveIncomeTaxRateReconciliationOtherAdjustments	-0.007	pure
CY2011	us-gaap	Effective Income Tax Rate Continuing Operations EffectiveIncomeTaxRateContinuingOperations	-0.000	pure
CY2012	us-gaap	Effective Income Tax Rate Continuing Operations EffectiveIncomeTaxRateContinuingOperations	0.122	pure
CY2010	us-gaap	Effective Income Tax Rate Continuing Operations EffectiveIncomeTaxRateContinuingOperations	-0.002	pure
CY2012Q4	us-gaap	Deferred Tax Assets Operating Loss Carryforwards DeferredTaxAssetsOperatingLossCarryforwards	244539000	USD
CY2011Q4	us-gaap	Deferred Tax Assets Operating Loss Carryforwards DeferredTaxAssetsOperatingLossCarryforwards	195399000	USD
CY2012	us-gaap	Effective Income Tax Rate Reconciliation State And Local Income Taxes EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes	0.057	pure
CY2011	us-gaap	Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance	-0.485	pure
CY2010	us-gaap	Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance	-0.439	pure
CY2012	us-gaap	Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance	-0.339	pure
CY2011	us-gaap	Effective Income Tax Rate Reconciliation Tax Credits EffectiveIncomeTaxRateReconciliationTaxCredits	-0.050	pure
CY2012	us-gaap	Effective Income Tax Rate Reconciliation Tax Credits EffectiveIncomeTaxRateReconciliationTaxCredits	0.011	pure
CY2010	us-gaap	Effective Income Tax Rate Reconciliation Tax Credits EffectiveIncomeTaxRateReconciliationTaxCredits	-0.052	pure
CY2011	us-gaap	Effective Income Tax Rate Reconciliation Minority Interest Income Expense EffectiveIncomeTaxRateReconciliationMinorityInterestIncomeExpense	0.017	pure
CY2010	us-gaap	Effective Income Tax Rate Reconciliation Minority Interest Income Expense EffectiveIncomeTaxRateReconciliationMinorityInterestIncomeExpense	0.015	pure
CY2011	isis	Effective Income Tax Rate Reconciliation Deferred Tax EffectiveIncomeTaxRateReconciliationDeferredTax	0.050	pure
CY2011Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	307488000	USD
CY2011Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	9834000	USD
CY2012Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	10872000	USD
CY2010	us-gaap	Current Federal Tax Expense Benefit CurrentFederalTaxExpenseBenefit	-73000	USD
CY2011	us-gaap	Current State And Local Tax Expense Benefit CurrentStateAndLocalTaxExpenseBenefit	11000	USD
CY2010	us-gaap	Current State And Local Tax Expense Benefit CurrentStateAndLocalTaxExpenseBenefit	165000	USD
CY2012	us-gaap	Current State And Local Tax Expense Benefit CurrentStateAndLocalTaxExpenseBenefit	2000	USD
CY2011	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	11000	USD
CY2010	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	92000	USD
CY2012	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-26105000	USD
CY2011	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-29677000	USD
CY2010	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-21438000	USD
CY2012	us-gaap	Income Tax Reconciliation State And Local Income Taxes IncomeTaxReconciliationStateAndLocalIncomeTaxes	-4284000	USD
CY2011	us-gaap	Income Tax Reconciliation State And Local Income Taxes IncomeTaxReconciliationStateAndLocalIncomeTaxes	-4870000	USD
CY2010	us-gaap	Income Tax Reconciliation State And Local Income Taxes IncomeTaxReconciliationStateAndLocalIncomeTaxes	-3518000	USD
CY2012	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	25269000	USD
CY2011	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	41136000	USD
CY2010	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	26869000	USD
CY2012	us-gaap	Income Tax Reconciliation Tax Credits IncomeTaxReconciliationTaxCredits	-806000	USD
CY2011	us-gaap	Income Tax Reconciliation Tax Credits IncomeTaxReconciliationTaxCredits	4202000	USD
CY2010	us-gaap	Income Tax Reconciliation Tax Credits IncomeTaxReconciliationTaxCredits	3175000	USD
CY2011	us-gaap	Income Tax Reconciliation Minority Interest Income Expense IncomeTaxReconciliationMinorityInterestIncomeExpense	-1448000	USD
CY2010	us-gaap	Income Tax Reconciliation Minority Interest Income Expense IncomeTaxReconciliationMinorityInterestIncomeExpense	-908000	USD
CY2012	isis	Income Tax Reconciliation Deferred Tax IncomeTaxReconciliationDeferredTax	839000	USD
CY2011	isis	Income Tax Reconciliation Deferred Tax IncomeTaxReconciliationDeferredTax	-4236000	USD
CY2012	us-gaap	Income Tax Reconciliation Other Adjustments IncomeTaxReconciliationOtherAdjustments	719000	USD
CY2011	us-gaap	Income Tax Reconciliation Other Adjustments IncomeTaxReconciliationOtherAdjustments	412000	USD
CY2010	us-gaap	Income Tax Reconciliation Other Adjustments IncomeTaxReconciliationOtherAdjustments	446000	USD
CY2011	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.350	pure
CY2010	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.350	pure
CY2012	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.350	pure
CY2011	us-gaap	Effective Income Tax Rate Reconciliation State And Local Income Taxes EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes	0.057	pure
CY2010	us-gaap	Effective Income Tax Rate Reconciliation State And Local Income Taxes EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes	0.057	pure
CY2012Q4	us-gaap	Deferred Tax Assets Tax Credit Carryforwards Research DeferredTaxAssetsTaxCreditCarryforwardsResearch	46928000	USD
CY2011Q4	us-gaap	Deferred Tax Assets Tax Credit Carryforwards Research DeferredTaxAssetsTaxCreditCarryforwardsResearch	44970000	USD
CY2012Q4	us-gaap	Deferred Tax Assets In Process Research And Development DeferredTaxAssetsInProcessResearchAndDevelopment	22223000	USD
CY2011Q4	us-gaap	Deferred Tax Assets In Process Research And Development DeferredTaxAssetsInProcessResearchAndDevelopment	23212000	USD
CY2012Q4	us-gaap	Deferred Tax Assets Deferred Income DeferredTaxAssetsDeferredIncome	7285000	USD
CY2011Q4	us-gaap	Deferred Tax Assets Deferred Income DeferredTaxAssetsDeferredIncome	20541000	USD
CY2012Q4	us-gaap	Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Restructuring Charges DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsRestructuringCharges	3605000	USD
CY2011Q4	us-gaap	Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Restructuring Charges DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsRestructuringCharges	10888000	USD
CY2012Q4	us-gaap	Deferred Tax Assets Other DeferredTaxAssetsOther	18931000	USD
CY2011Q4	us-gaap	Deferred Tax Assets Other DeferredTaxAssetsOther	25606000	USD
CY2012Q4	us-gaap	Deferred Tax Assets Gross DeferredTaxAssetsGross	343511000	USD
CY2011Q4	us-gaap	Deferred Tax Assets Gross DeferredTaxAssetsGross	320616000	USD
CY2011Q4	us-gaap	Deferred Tax Liabilities Financing Arrangements DeferredTaxLiabilitiesFinancingArrangements	9426000	USD
CY2011Q4	isis	Deferred Tax Liabilities Property Plant And Equipment And Goodwill And Intangible Assets DeferredTaxLiabilitiesPropertyPlantAndEquipmentAndGoodwillAndIntangibleAssets	3702000	USD
CY2011Q4	isis	Deferred Tax Assets Liabilities Before Valuation Allowance DeferredTaxAssetsLiabilitiesBeforeValuationAllowance	307488000	USD
CY2012	isis	Defined Contribution Plan Employee Contribution Limit By Plan Participants Under Fifty Years Age DefinedContributionPlanEmployeeContributionLimitByPlanParticipantsUnderFiftyYearsAge	17000	USD
CY2012	isis	Defined Contribution Plan Employee Contribution Limit By Plan Participants Over Fifty Years Age DefinedContributionPlanEmployeeContributionLimitByPlanParticipantsOverFiftyYearsAge	22500	USD
CY2012	us-gaap	Defined Contribution Plan Cost Recognized DefinedContributionPlanCostRecognized	529000	USD
CY2011	us-gaap	Defined Contribution Plan Cost Recognized DefinedContributionPlanCostRecognized	487000	USD
CY2010	us-gaap	Defined Contribution Plan Cost Recognized DefinedContributionPlanCostRecognized	449000	USD
CY2012Q1	us-gaap	Revenues Revenues	23235000	USD
CY2012Q2	us-gaap	Revenues Revenues	47340000	USD
CY2012Q3	us-gaap	Revenues Revenues	11601000	USD
CY2012Q4	us-gaap	Revenues Revenues	19873000	USD
CY2012Q1	us-gaap	Operating Expenses OperatingExpenses	41690000	USD
CY2012Q2	us-gaap	Operating Expenses OperatingExpenses	43644000	USD
CY2012Q3	us-gaap	Operating Expenses OperatingExpenses	39647000	USD
CY2012Q4	us-gaap	Operating Expenses OperatingExpenses	45992000	USD
CY2012Q1	us-gaap	Operating Income Loss OperatingIncomeLoss	-18455000	USD
CY2012Q2	us-gaap	Operating Income Loss OperatingIncomeLoss	3696000	USD
CY2012Q3	us-gaap	Operating Income Loss OperatingIncomeLoss	-28046000	USD
CY2012Q4	us-gaap	Operating Income Loss OperatingIncomeLoss	-26119000	USD
CY2012Q1	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-23995000	USD
CY2012Q2	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-1207000	USD
CY2012Q3	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-37639000	USD
CY2012Q4	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-2637000	USD
CY2012Q1	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.24
CY2012Q2	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.01
CY2012Q3	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.37
CY2012Q4	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.03
CY2011Q1	us-gaap	Revenues Revenues	21147000	USD
CY2011Q2	us-gaap	Revenues Revenues	24823000	USD
CY2011Q3	us-gaap	Operating Income Loss OperatingIncomeLoss	-22316000	USD
CY2011Q4	us-gaap	Operating Income Loss OperatingIncomeLoss	-18616000	USD
CY2011Q1	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-19994000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due In Three Years OperatingLeasesFutureMinimumPaymentsDueInThreeYears	1332000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due In Four Years OperatingLeasesFutureMinimumPaymentsDueInFourYears	1380000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due In Five Years OperatingLeasesFutureMinimumPaymentsDueInFiveYears	1401000	USD
CY2011Q3	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-26882000	USD
CY2011Q4	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-20036000	USD
CY2011Q1	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.20
CY2011Q2	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.18
CY2011Q3	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.27
CY2011Q4	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-0.20
CY2012	us-gaap	Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Tax OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax	-9111000	USD
CY2010	isis	Stock Issued During Period Value Warrants Exercised StockIssuedDuringPeriodValueWarrantsExercised	0	USD
CY2010	us-gaap	Other Comprehensive Income Loss Reclassification Adjustment For Sale Of Securities Included In Net Income Net Of Tax OtherComprehensiveIncomeLossReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax	138000	USD
CY2012Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	12480000	USD
CY2012	isis	Adjustments To Additional Paid In Capital Tax Effect From Share Based Compensation Expected AdjustmentsToAdditionalPaidInCapitalTaxEffectFromShareBasedCompensationExpected	10600000	USD
CY2012	us-gaap	Adjustments To Additional Paid In Capital Equity Component Of Convertible Debt Subsequent Adjustments AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments	-12041000	USD
CY2012Q4	us-gaap	Deferred Rent Credit DeferredRentCredit	1400000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due Current OperatingLeasesFutureMinimumPaymentsDueCurrent	1423000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due In Two Years OperatingLeasesFutureMinimumPaymentsDueInTwoYears	1389000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due Thereafter OperatingLeasesFutureMinimumPaymentsDueThereafter	20578000	USD
CY2012Q4	us-gaap	Operating Leases Future Minimum Payments Due OperatingLeasesFutureMinimumPaymentsDue	27503000	USD
CY2012	us-gaap	Lease And Rental Expense LeaseAndRentalExpense	1900000	USD
CY2011	us-gaap	Lease And Rental Expense LeaseAndRentalExpense	4600000	USD
CY2010	us-gaap	Lease And Rental Expense LeaseAndRentalExpense	4300000	USD
CY2011Q4	us-gaap	Deferred Rent Credit DeferredRentCredit	1200000	USD
CY2012	us-gaap	Amortization Of Debt Discount Premium AmortizationOfDebtDiscountPremium	8400000	USD
CY2006Q2	us-gaap	Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights	4250000	shares
CY2006Q2	us-gaap	Class Of Warrant Or Right Exercise Price Of Warrants Or Rights ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights	8.93
CY2012	us-gaap	Gain Loss On Investments GainLossOnInvestments	1465000	USD
CY2012	us-gaap	Other Than Temporary Impairment Losses Investments Portion Recognized In Earnings Net Availableforsale Securities OtherThanTemporaryImpairmentLossesInvestmentsPortionRecognizedInEarningsNetAvailableforsaleSecurities	880000	USD
CY2012	us-gaap	Concentration Risk Credit Risk ConcentrationRiskCreditRisk	<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="MARGIN: 0in 0in 0pt"><b><font style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman" size="2">Concentration of credit risk</font></b></p> <p style="MARGIN: 0in 0in 0pt"><font style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman" size="2"> </font></p> <p style="MARGIN: 0in 0in 0pt; TEXT-INDENT: 0.5in"><font style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman" size="2">Financial instruments that potentially subject us to concentrations of credit risk consist primarily of cash equivalents, short-term investments and receivables. We place our cash equivalents and certain of our short-term investments with reputable financial institutions. We primarily invest our excess cash in commercial paper and debt instruments of the U.S. Treasury, financial institutions, corporations, and U.S. government agencies with strong credit ratings and an investment grade rating at or above A-1, P-1 or F-1 by Moody’s, Standard & Poor’s (S&P) or Fitch, respectively.  We have established guidelines relative to diversification and maturities that maintain safety and liquidity. We periodically review and modify these guidelines to maximize trends in yields and interest rates without compromising safety and liquidity.</font></p></div>
CY2012	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	1292000	USD
CY2012Q4	us-gaap	Land Land	10198000	USD
CY2012	us-gaap	Increase Decrease In Other Operating Assets IncreaseDecreaseInOtherOperatingAssets	-279000	USD
CY2011Q4	us-gaap	Land Land	10198000	USD
CY2011Q4	isis	Long Term Debt And Other Noncurrent LongTermDebtAndOtherNoncurrent	215450000	USD
CY2012Q4	isis	Long Term Debt And Other Noncurrent LongTermDebtAndOtherNoncurrent	221942000	USD
CY2012	isis	Leases Number Of Buildings LeasesNumberOfBuildings	3	building
CY2012Q4	us-gaap	Area Of Real Estate Property AreaOfRealEstateProperty	231000
CY2012	us-gaap	Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions	174000	USD
CY2012	us-gaap	Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions	421000	USD
CY2012Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	124482000	USD
CY2012Q4	us-gaap	Available For Sale Securities Debt Securities Current AvailableForSaleSecuritiesDebtSecuritiesCurrent	249964000	USD
CY2012Q4	us-gaap	Receivables Long Term Contracts Or Programs ReceivablesLongTermContractsOrPrograms	522000	USD
CY2012Q4	isis	Licenses Net LicensesNet	6579000	USD
CY2012Q4	isis	Patents Net PatentsNet	18646000	USD
CY2012Q4	isis	Deposits And Other Assets Noncurrent DepositsAndOtherAssetsNoncurrent	5939000	USD
CY2012Q4	us-gaap	Accounts Payable Current AccountsPayableCurrent	10239000	USD
CY2012Q4	us-gaap	Employee Related Liabilities Current EmployeeRelatedLiabilitiesCurrent	7878000	USD
CY2012Q4	us-gaap	Other Assets Current OtherAssetsCurrent	8727000	USD
CY2012Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	15401000	USD
CY2012Q4	us-gaap	Deferred Revenue Current DeferredRevenueCurrent	35925000	USD
CY2012Q4	us-gaap	Deferred Revenue Noncurrent DeferredRevenueNoncurrent	66656000	USD
CY2012Q4	isis	Capital Lease And Other Long Term Borrowings Non Current CapitalLeaseAndOtherLongTermBorrowingsNonCurrent	7402000	USD
CY2012Q4	isis	Long Term Financing Obligation LongTermFinancingObligation	70550000	USD
CY2012Q4	us-gaap	Common Stock Value CommonStockValue	102000	USD
CY2012Q4	us-gaap	Additional Paid In Capital Common Stock AdditionalPaidInCapitalCommonStock	1077150000	USD
CY2012Q4	us-gaap	Retained Earnings Accumulated Deficit RetainedEarningsAccumulatedDeficit	-906966000	USD
CY2012	us-gaap	General And Administrative Expense GeneralAndAdministrativeExpense	12515000	USD
CY2012	us-gaap	Income Loss From Equity Method Investments IncomeLossFromEquityMethodInvestments	-1406000	USD
CY2012	us-gaap	Interest Expense InterestExpense	21152000	USD
CY2012	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	100576000	shares
CY2012	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	100576000	shares
CY2012	us-gaap	Adjustments To Additional Paid In Capital Equity Component Of Convertible Debt AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt	57560000	USD
CY2012	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	8571000	USD
CY2012	isis	Amortization Of Patents AmortizationOfPatents	1224000	USD
CY2012	isis	Amortization Of Licenses AmortizationOfLicenses	2457000	USD
CY2012	us-gaap	Investment Income Net Amortization Of Discount And Premium InvestmentIncomeNetAmortizationOfDiscountAndPremium	-4193000	USD
CY2012	us-gaap	Amortization Of Financing Costs AmortizationOfFinancingCosts	619000	USD
CY2012	us-gaap	Share Based Compensation ShareBasedCompensation	8571000	USD
CY2012	isis	Income Losses Related To Patents And Property Plant And Equipment IncomeLossesRelatedToPatentsAndPropertyPlantAndEquipment	-825000	USD
CY2012	isis	Increase Decrease In Contracts Receivable Net IncreaseDecreaseInContractsReceivableNet	-6399000	USD
CY2012	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	1982000	USD
CY2012	us-gaap	Increase Decrease In Other Employee Related Liabilities IncreaseDecreaseInOtherEmployeeRelatedLiabilities	-1305000	USD
CY2012	us-gaap	Increase Decrease In Deferred Liabilities IncreaseDecreaseInDeferredLiabilities	255000	USD
CY2012	us-gaap	Increase Decrease In Accrued Liabilities IncreaseDecreaseInAccruedLiabilities	-3254000	USD
CY2012	us-gaap	Increase Decrease In Deferred Revenue IncreaseDecreaseInDeferredRevenue	48523000	USD
CY2012	us-gaap	Payments To Acquire Available For Sale Securities Debt PaymentsToAcquireAvailableForSaleSecuritiesDebt	217877000	USD
CY2012	us-gaap	Proceeds From Sale And Maturity Of Available For Sale Securities ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities	242659000	USD
CY2012	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	1479000	USD
CY2012	isis	Payments To Acquire Licenses And Other Assets PaymentsToAcquireLicensesAndOtherAssets	3691000	USD
CY2012	isis	Purchases Of Strategic Investments PurchasesOfStrategicInvestments	790000	USD
CY2012	isis	Proceeds From The Sale Of Strategic Investments ProceedsFromTheSaleOfStrategicInvestments	2177000	USD
CY2012	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	9470000	USD
CY2012	isis	Proceeds From Equipment Financing Arrangement ProceedsFromEquipmentFinancingArrangement	9100000	USD
CY2012	us-gaap	Repayments Of Long Term Debt And Capital Securities RepaymentsOfLongTermDebtAndCapitalSecurities	10419000	USD
CY2012	us-gaap	Interest Paid InterestPaid	5770000	USD
CY2012	isis	Noncash Capital And Patent Expenditures NoncashCapitalAndPatentExpenditures	647000	USD
CY2010	us-gaap	Amortization Of Debt Discount Premium AmortizationOfDebtDiscountPremium	7800000	USD
CY2011	us-gaap	Amortization Of Debt Discount Premium AmortizationOfDebtDiscountPremium	8600000	USD
CY2012	us-gaap	Gain Loss On Sale Of Previously Unissued Stock By Subsidiary Or Equity Investee Nonoperating Income GainLossOnSaleOfPreviouslyUnissuedStockBySubsidiaryOrEquityInvesteeNonoperatingIncome	18356000	USD
CY2012	isis	Amortization Of Debt Discount Premium Two AmortizationOfDebtDiscountPremiumTwo	2268000	USD
CY2012	isis	Amortization Of Long Term Financing Liability For Leased Facility AmortizationOfLongTermFinancingLiabilityForLeasedFacility	6503000	USD
CY2012	isis	Payments To Acquire Previously Unissued Stock Sold By Subsidiary Or Equity Investee PaymentsToAcquirePreviouslyUnissuedStockSoldBySubsidiaryOrEquityInvestee	3000000	USD
CY2011	isis	Amortization Of Long Term Financing Liability For Leased Facility AmortizationOfLongTermFinancingLiabilityForLeasedFacility	2872000	USD
CY2010	us-gaap	Share Based Compensation ShareBasedCompensation	12159000	USD
CY2010	us-gaap	Gain Loss On Sale Of Property Plant Equipment GainLossOnSaleOfPropertyPlantEquipment	72000	USD
CY2010	us-gaap	Increase Decrease In Accrued Income Taxes Payable IncreaseDecreaseInAccruedIncomeTaxesPayable	-7178000	USD
CY2011Q4	us-gaap	Equity Method Investments EquityMethodInvestments	-4424000	USD
CY2010	us-gaap	Gain Loss On Sale Of Previously Unissued Stock By Subsidiary Or Equity Investee Nonoperating Income GainLossOnSaleOfPreviouslyUnissuedStockBySubsidiaryOrEquityInvesteeNonoperatingIncome	4651000	USD
CY2012Q4	us-gaap	Variable Interest Entity Nonconsolidated Carrying Amount Assets VariableInterestEntityNonconsolidatedCarryingAmountAssets	38500000	USD
CY2011	isis	Amortization Of Debt Discount Premium One AmortizationOfDebtDiscountPremiumOne	8553000	USD
CY2010	isis	Amortization Of Debt Discount Premium One AmortizationOfDebtDiscountPremiumOne	7795000	USD
CY2012	isis	Amortization Of Debt Discount Premium One AmortizationOfDebtDiscountPremiumOne	6169000	USD
CY2010	isis	Reporting Segments Previous Number ReportingSegmentsPreviousNumber	2	segment
CY2012Q4	isis	Significant Equity Investment SignificantEquityInvestment	33622000	USD
CY2011	us-gaap	Income Tax Expense Benefit Intraperiod Tax Allocation IncomeTaxExpenseBenefitIntraperiodTaxAllocation	11000	USD
CY2010	us-gaap	Income Tax Expense Benefit Intraperiod Tax Allocation IncomeTaxExpenseBenefitIntraperiodTaxAllocation	92000	USD
CY2012	us-gaap	Income Tax Expense Benefit Intraperiod Tax Allocation IncomeTaxExpenseBenefitIntraperiodTaxAllocation	-9109000	USD
CY2012	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	2000	USD
CY2012	us-gaap	Deferred Federal Income Tax Expense Benefit DeferredFederalIncomeTaxExpenseBenefit	-7827000	USD
CY2012	us-gaap	Deferred State And Local Income Tax Expense Benefit DeferredStateAndLocalIncomeTaxExpenseBenefit	-1284000	USD
CY2012	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	-9111000	USD
CY2012Q4	us-gaap	Deferred Tax Liabilities Financing Arrangements DeferredTaxLiabilitiesFinancingArrangements	23322000	USD
CY2012Q4	isis	Deferred Tax Liabilities Property Plant And Equipment And Goodwill And Intangible Assets DeferredTaxLiabilitiesPropertyPlantAndEquipmentAndGoodwillAndIntangibleAssets	6784000	USD
CY2012Q4	isis	Deferred Tax Assets Liabilities Before Valuation Allowance DeferredTaxAssetsLiabilitiesBeforeValuationAllowance	313405000	USD
CY2012Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	-313405000	USD
CY2010Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	8968000	USD
CY2011	us-gaap	Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions	97000	USD
CY2012	us-gaap	Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions	791000	USD
CY2011	us-gaap	Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions	963000	USD
CY2010	us-gaap	Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions	737000	USD
CY2012	isis	Income Tax Reconciliation Gain Loss On Sale Of Previously Unissued Stock By Subsidiary Or Equity Investee Nonoperating Income IncomeTaxReconciliationGainLossOnSaleOfPreviouslyUnissuedStockBySubsidiaryOrEquityInvesteeNonoperatingIncome	-6353000	USD

Files In Submission

Name	View Source	Status
0001104659-13-016208-index-headers.html	Edgar Link	pending
0001104659-13-016208-index.html	Edgar Link	pending
0001104659-13-016208.txt	Edgar Link	pending
0001104659-13-016208-xbrl.zip	Edgar Link	pending
a12-28450_110k.htm	Edgar Link	pending
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Financial_Report.xls	Edgar Link	pending
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isis-20121231.xml	Edgar Link	completed
isis-20121231.xsd	Edgar Link	pending
isis-20121231_cal.xml	Edgar Link	unprocessable
isis-20121231_def.xml	Edgar Link	unprocessable
isis-20121231_lab.xml	Edgar Link	unprocessable
isis-20121231_pre.xml	Edgar Link	unprocessable
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report.css	Edgar Link	pending
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2012 Q4 Form 10-K Financial Statement

#000110465913016208 Filed on February 28, 2013

Income Statement

Balance Sheet

Cashflow Statement

Facts In Submission

Files In Submission

$IONS IONIS PHARMACEUTICALS INC Stock $ions

2012 Q4 Form 10-K Financial Statement

#000110465913016208 Filed on February 28, 2013

Income Statement

Balance Sheet

Cashflow Statement

Facts In Submission

Files In Submission

$IONS
IONIS PHARMACEUTICALS INC Stock $ions