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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation | |||||
| Amortization of right-of-use operating lease assets | |||||
| Amortization of other assets | |||||
| Amortization of discount on investments, net | |||||
| Amortization of debt issuance costs | |||||
| Non-cash royalty revenue related to sale of royalties | |||||
| Non-cash interest related to sale of future royalties | |||||
| Stock-based compensation expense | |||||
| Gain on early retirement of debt | |||||
| Inducement expense related to early retirement of debt | |||||
| Non-cash losses (gains) related to disposal of property, plant and equipment | |||||
| Loss (gain) on sale of real estate assets | |||||
| Loss (gain) on investments, net | |||||
| Non-cash losses related to other assets | |||||
| Changes in operating assets and liabilities: | |||||
| Contracts receivable | |||||
| Inventories | |||||
| Other current and long-term assets | |||||
| Accounts payable | |||||
| Income taxes | |||||
| Accrued compensation | |||||
| Accrued liabilities and other liabilities | |||||
| Deferred contract revenue | |||||
| Net cash used in operating activities | |||||
| Investing activities: | |||||
| Purchases of short-term investments | |||||
| Proceeds from sale of short-term investments | |||||
| Purchases of property, plant and equipment | |||||
| Proceeds from sale of real estate assets | |||||
| Acquisition of licenses and other assets, net | |||||
| Purchases of strategic investments | |||||
| Net cash used in investing activities | |||||
| Financing activities: | |||||
| Proceeds from issuance of common stock through equity plans, net | |||||
| Proceeds from issuance of common stock in public offering, net | |||||
| Proceeds from issuance of convertible senior notes | |||||
| 1.75 Percent Convertible Senior Notes | |||||
| 0 Percent Convertible Senior Notes | |||||
| 0% Notes due 2030 | |||||
| 1.75% Notes due 2028 | |||||
| Total proceeds from issuance of convertible senior notes | |||||
| Convertible senior notes issuance costs | |||||
| 1.75 Percent Convertible Senior Notes | |||||
| 0 Percent Convertible Senior Notes | |||||
| 0% Notes due 2030 | |||||
| 1.75% Notes due 2028 | |||||
| Total convertible senior notes issuance costs | |||||
| Proceeds from sale of future royalties | |||||
| Payments of transaction costs related to sale of future royalties | |||||
| Proceeds from real estate transaction | |||||
| Principal payments on mortgage debt | |||||
| Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options | |||||
| Net cash provided by financing activities | |||||
| Effects of exchange rates on cash | |||||
| Repurchase of $200 million principal amount of 0 percent convertible senior notes due 2026 | |||||
| 0.125 Percent Convertible Senior Notes | |||||
| 1 Percent Convertible Senior Notes | |||||
| Total repurchase of $200 million principal amount of 0 percent convertible senior notes due 2026 | |||||
| Repayment of 0.125 percent convertible senior notes due 2024 | |||||
| 0.125 Percent Convertible Senior Notes | |||||
| Total repayment of 0.125 percent convertible senior notes due 2024 | |||||
| Proceeds from issuance of warrants | |||||
| Total proceeds from issuance of warrants | |||||
| Purchase of note hedges | |||||
| Total purchase of note hedges | |||||
| Effects of exchange rates on cash | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of year | |||||
| Cash and cash equivalents at end of year | |||||
| Supplemental disclosures of cash flow information: | |||||
| Interest paid | |||||
| Income taxes paid (refunds received), net | |||||
| Supplemental disclosures of non-cash investing and financing activities: | |||||
| Right-of-use assets obtained in exchange for lease obligations | |||||
| Amounts accrued for capital and patent expenditures | |||||
| Inducement related to repurchase of 0 percent convertible senior notes due 2026 | |||||
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